Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats

Filho, Douglas Haddad; Zveibel, Deborah K.; Alonso, Nivaldo; Gemperli, Rolf

doi:10.1590/s0102-86502007000300006

Cited by 9 publications

(16 citation statements)

References 19 publications

(31 reference statements)

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“…To compare the inflammatory reaction caused by the implant of textured silicone with the same reaction caused by the implant of textured silicone covered by E-PTFE Haddad Son et al 26 observed that both induced chronic inflammatory reaction and weak inflammatory reaction type strange body similar to the present study.…”

Section: Resultssupporting

confidence: 81%

Histopathological reaction over prosthesis surface covered with silicone and polyurethane foam implanted in rats

et al. 2012

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PURPOSES: To evaluate whether polyurethane foam leads more intense foreign-body reaction than silicone foam. To compare the vascularization of the capsules surrounding the foam implants. To investigate if the capsule of polyurethane foam implanted has greater amount of collagen than that of silicone foam. METHODS: Sixty-four young male Wistar rats were allocated into two groups: polyurethane foam and silicone foam. Subcutaneous discs were implanted into the dorsum of the animals in both groups. The capsules were assessed 28 days, two months, three months and six months postoperatively. Microscopic analysis with H&E stain was performed to evaluate the acute and chronic inflammatory process, foreign-body reaction and neovascularization. The analysis with picrosirius red was performed using the ImageProPlus software, to measure the number of vessels and collagen types I and III. RESULTS: There were no statistical differences between the two groups regarding the acute and chronic inflammatory processes. All rats from the polyurethane group, in all times, exhibited moderate or intense foreign-body reaction, with statistic significant difference (p=0.046) when compared with the silicone group, in which the reaction was either mild or nonexistent at two months. Vascular proliferation was significantly different between the groups at 28 days (p=0.0002), with the polyurethane group displaying greater neovascularization with H&E stain. Similar results were obtained with picrosirius red, which revealed in the polyurethane group a much greater number of vessels than in the silicone group (p=0.001). The collagen area was larger in the polyurethane group, significantly at 28 days (p=0.001) and at two months (p=0.030). CONCLUSIONS: Polyurethane foam elicited more intense foreign-body reaction when compared with silicone foam. The number of vessels was higher in the capsules of the polyurethane foam implants 28 days after the operation. The capsule of the polyurethane foam implants showed a greater amount of collagen than that of the silicone foam implants.

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Section: Resultssupporting

confidence: 81%

Histopathological reaction over prosthesis surface covered with silicone and polyurethane foam implanted in rats

et al. 2012

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“…This study suggests the hypothesis that there might be less contraction in the textured prostheses due to the decrease of adhesive capsular characteristic, thus decreasing the mechanical friction previously mentioned 9,14 . The necessary force to loosen the membrane´s periimplant tissue indirectly demonstrated the invasion of this tissue inside the coating's texture.…”

Section: Discussionsupporting

confidence: 60%

“…However, polyurethane is responsible for intense inflammatory reaction, with relevant lining phagocytosis and lining degradation, making its removal difficult when it is necessary 8 . Haddad Filho et al 9 confirm that one of the most significant modifications in silicone implants was the texture of their surfaces.…”

Section: Introductionmentioning

confidence: 96%

Healing reaction to mammary prostheses covered by textured silicone and silicone foam in rats

et al. 2009

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Purpose:To compare the capsular reaction to two different coverings of silicone prosthesis through the biophysical characteristic of adherence and microscopical aspects of the inflammatory reaction and collagen formation. Methods: Thirty two Wistar rats were used. In the dorsum of each animal a silicone elastomer with a smooth superficies and another coated with texturized silicone (Mentor) was implanted. Another one, with the same smooth superficies and other coated with silicone foam (Lifesil), making up in each side, of the dorsum, the texturized and silicone foam group respectively. The animals were split into four groups to be evaluated at 7, 14, 30 and 60 days. On the evaluation dates the implant adherence was verified witch a tensiometer and the values in kgf were obtained. The material was sent to histological analysis with hematoxilin-eosin and picrosirius colorations, to evaluate the inflammatory reaction and collagen synthesis, respectively. The obtained data were submitted to statistical treatment. Results: There was more adherence of the tissue to the silicone foam (P<0,001). The inflammatory reaction was more intense in the same group, but without statistical significance. The number of giant cells and granulomas were more frequent in the silicone foam group. There was statistical significance at the 60 days for granulomas (P<0,028) and for all subgroups about number of giant cells (P< 0,012 to P<0,036). The thickness of the capsule in the silicone foam group was bigger, with statistical significance at seven days (P<0,028) and 60 days (P<0,012). The collagen deposition showed no difference in statistical analysis. Conclusion: The capsular reaction to the silicone foam showed stronger adherence, bigger thickness and had more number of granulomas and giant cells. No difference was observed in the intensity of inflammatory reaction in relation to type I and III collagen, when compared to the texturized cover. Key words: Breast Implantation. Silicones. Biocompatible Materials. Contracture. Rats. RESUMO Objetivo:Comparar a reação capsular de dois revestimentos de próteses de silicone através da característica biofísica de aderência e dos aspectos microscópicos de reação inflamatória e formação de colágeno. Métodos: Implantaram-se no dorso de 32 ratos duas membranas de silicone ambas possuindo uma superfície lisa e outra diferindo em sua estrutura. Estes revestimentos foram de espuma de silicone (LifeSil) ou silicone texturizado (Mentor). Os dois grupos foram divididos em quatro sub-grupos conforme o tempo de pós-operatório avaliado: 7, 14, 30 e 60 dias. Obteve-se material para análise biofísica de aderência, a qual foi realizada com tensiômetro para obtenção de valores em kgf. O estudo microscópico da reação inflamatória e síntese de colágeno foi realizado com colorações de hematoxilina-eosina e picrosirius. Os dados foram submetidos a testes para avaliação da significância estatística. Resultados: Houve maior aderência do revestimento de espuma de silicone ao tecido capsular, sendo este valor...

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“…Disagreeing with Haddad Filho et al 16 that found greater number of capillaries in the textured and PTFE-E groups in relation to the control group with statistical significance in various subgroups, in this study all rats that took part in the textured group had absence or discrete presence of this variable with no significant difference.…”

Section: Evaluation Of Neoangiogenesissupporting

confidence: 42%

“…According to Ratner 15 Haddad Filho et al 16 after comparing silicone implants with a textured surface and coated PTFE-E, it was concluded that both groups induced a weak foreign body reaction, which was higher in textured group. Disagreeing with this author, in this study the foreign body reaction was absent in the textured group at all subgroups.…”

Section: Evaluation Of Foreign Body Reactionmentioning

confidence: 99%

Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats

Silva¹,

Ribas-Filho²,

Czeczko³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS:Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed for 30, 50, 70 and 90 days. Were analyzed the following parameters: foreign body reaction, granulation tissue, presence of myofibroblasts, neoangiogenesis, presence of synovial metaplasia, capsular thickness, total area and collagen percentage of type I and III, in capsules formed around silicone implants in both groups. RESULTS:The foreign body reaction was only present in the four polyurethane subgroups. The formation of granulation tissue and the presence of myofibroblasts were higher in the four polyurethane subgroups. Regarding to neoangiogenesis and synovial metaplasia, there was no statistical difference between the groups. Polyurethane group presented (all subgroups) a greater capsule thickness, a smaller total area and collagen percentage of type I and a higher percentage area of type III, with statistical difference. CONCLUSION:The use of polyurethane-coated implants should be stimulated by the long-term results in a more stable capsule and a lower incidence of capsular contracture, despite developing a more intense and delayed inflammatory reaction in relation to implants with textured surface.

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Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats

Cited by 9 publications

References 19 publications

Histopathological reaction over prosthesis surface covered with silicone and polyurethane foam implanted in rats

Histopathological reaction over prosthesis surface covered with silicone and polyurethane foam implanted in rats

Healing reaction to mammary prostheses covered by textured silicone and silicone foam in rats

Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats

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