Efeito do extrato de Passiflora edulis (maracujá) na cicatrização de bexiga em ratos: estudo morfológico

Abstract

Efeito do extrato de ABSTRACT Purpose:To evaluate the effects of hydroalcoholic extract of Passiflora edulis leaves in the healing of urinary bladder in rats from histological aspects. Methods: Forty Wistar male rats were submitted to a longitudinal incision of the bladder followed by a stetching in only one level. After this common procedure, animals were divided at random two groups: Passiflora and Control. In the Passiflora group the only dosage used was administered by intraperitonial injection of hydoalcoholic extract of Passiflora edulis leaves while in the Control group distilled water was injected. Each subgroup was then divided in two subgroups according to the death of these animals: Control, three and seven days, Passiflora, three and seven days. After the death of these animals, an inventory of the abdominal cavity was performed and the bladder was removed. A comparative analysis was done between the two groups with microscopic evaluation of the healing. There was less acute inflammation (p=0.008), greater colagenous formation (p=0.001) and greater capillary neo-formation (p=0.000) in the third day Passiflora subgroup when compared to the Control subgroup of the third day. Results: There was less acute inflammation (p=0.001), greater fibroblastic proliferation (p=0.011) and greater colagenous formation (p=0.001) in the Passiflora subgroup of seventh day when compared with the Control seventh day subgroup. Conclusion: The use of Passiflora edulis leaves extract resulted in less acute inflammation, greater fibroblastic proliferation, colagenous formation and capillary neo-formation on rats bladder wound healing. Key words: Passiflora edulis. Wound Healing. Bladder. Rats. IntroduçãoA cicatrização é um processo que visa limitar os danos e restabelecer a integridade e a função dos tecidos afetados 1 .Os avanços da biologia celular e molecular têm permitido o estudo e ampliado o conhecimento das etapas da cicatrização. Sabe-se que os tecidos cicatrizam-se de maneira

Activity of Orbignya Phalerata and Euterpe Edules in the Prevention and Treatment of Peptic Ulcer in Rats

“…The anti-ulcer activity of several chemical compounds isolated from plants has been determined. In Brazil, several plant extracts are used in popular medicine for the treatment of digestive disorders, including gastric ulcers 4 , 5 , 7 , 8 , 9 .…”

“…Its highest concentration is in the State of Maranhão. Piauí, Pará and Tocantins states are also major domestic producers 1 , 2 , 5 , 6 , 16 . Its leaf straws are transformed into baskets, the bark of the coconut is transformed into charcoal and the chestnut in oil and soap.…”

Applying design of experiments (DOE) to flavonoid extraction from Passiflora alata and P. edulis

“…The use of P. edulis leaves extract resulted in improved wound healing (Gonçalves-Filho et al, 2006;Gomes et al, 2006) and the inhibition of parasite growth (Bezerra et al, 2006). The aqueous extract of the root was effective against three types of viruses (Müller et al, 2007).…”

Evaluación de la toxicidad del extracto metanólico de hojas de Passiflora edulis Sims (maracuyá), en ratas

“…El extracto del fruto inhibió las enzimas que tienen actividad de endopeptidasas dependientes de zinc, las metaloproteinasas de matriz extracelular MMP-2 y MMP-9 involucradas en la invasión tumoral, metástasis y angiogénesis (7) , así como también inhibió la transformación neoplásica de células murinas 3T3 BALB/c tratadas con benzopireno (8) ; el extracto de las hojas disminuyó la inflamación aguda y aumentó la proliferación fibroblástica, la colagenización y la neoformación capilar en la cicatrización de la vejiga de ratas (9) ; también, mostró una significativa actividad antiinflamatoria sobre pleuresía inducida por carragenina en ratones (10,11) ; además, aumentó significativamente el número de ratones protegidos contra convulsiones inducidas por estricnina, de manera semejante al clonazepam (12) ; y tuvo actividad antiviral contra herpes virus simple tipo 1, HSV-1 (13) . Por otra parte, se ha aislado un péptido antifún-gico en las semillas de P. edulis (14) .…”