Nonalcoholic fatty liver disease and obesity

Júnior, Wilson Salgado; Santos, José Sebastião dos; Sankarankutty, Ajith Kumar; Silva, Orlando de Castro e

doi:10.1590/s0102-86502006000700017

Cited by 15 publications

(5 citation statements)

References 31 publications

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“…A subset of patients presenting hepatic steatosis will evolve with steatohepatitis, dramatically increasing the risk of cirrhosis, liver failure and hepatocellular carcinoma. Currently, NAFLD and nonalcoholic steatohepatitis are considered the number one cause of hepatic illnesses in Western countries 8 , 12 , 21 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Hepatic Profile in Pre and Postoperative of Bariatric Surgery: Private vs Public Network

Nascimento

Alves-Júnior

Nunes

et al. 2015

ABCD, arq. bras. cir. dig.

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Background: Obesity is associated to several comorbidities, including nonalcoholic fatty liver disease, which implicates in isolated steatosis to steatohepatitis. The latter may progress to severe manifestations such as liver fibrosis, cirrhosis and hepatocellular carcinoma. Aim: To compare the presence of advanced liver fibrosis before and after bariatric surgery in patients of private and public health system. Methods: Patients from public and privative networks were studied before and after bariatric surgery. The presence or absence of advanced hepatic fibrosis was evaluated by NAFLD Fibrosis Score, a non-invasive method that uses age, BMI, AST/ALT ratio, albumin, platelet count and the presence or absence of hyperglycemia or diabetes. The characteristics of the two groups were compared. The established statistical significance criterion was p<0.05. Results: Were analyzed 40 patients with a mean age of 34.6±9.5 years for private network and 40.6± 10.2 years for public. The study sample, 35% were treated at private health system and 65% in the public ones, 38% male and 62% female. Preoperatively in the private network one (7.1%) patient had advanced liver fibrosis and developed to the absence of liver fibrosis after surgery. In the public eight (30.8%) patients had advanced liver fibrosis preoperatively, and at one year after the proportion fell to six (23%). Conclusion: The non-alcoholic fatty liver disease in its advanced form is more prevalent in obese patients treated in the public network than in the treated at the private network and bariatric surgery may be important therapeutic option in both populations.

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Section: Introductionmentioning

confidence: 99%

Comparison of Hepatic Profile in Pre and Postoperative of Bariatric Surgery: Private vs Public Network

Nascimento

Alves-Júnior

Nunes

et al. 2015

ABCD, arq. bras. cir. dig.

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“…In the past few decades, there has been a worldwide increase in the prevalence of obesity and associated metabolic disorders including glucose intolerance, insulin resistance [1], dyslipidemia, hypertension, and visceral adiposity [2,3]. In clinical practice, the presence of these conditions defines the metabolic syndrome (MS), which, independently of the criteria used for its diagnosis (WHO, NCEP: ATP III, EGIR) [4], is associated with an increased risk of cardiovascular events, a proinflammatory and prothrombotic state, and the occurrence of nonalcoholic fatty liver disease [2,[5][6][7]. Several authors have noticed clinical similarities between hypercortisolism effects seen in the Cushing syndrome and the group of disorders related to MS and central obesity, postulating that MS could be conceived as a subclinical form of Cushing's syndrome with normal plasma glucocorticoid levels [8,9].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients

et al. 2009

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“…We found a predominance of the disease in middle-aged women and an association between older patients and higher degree of liver fibrosis ( P = 0.001). The correlation with gender is controversial: early studies claimed that NAFLD was more common in women, but the latest concluded the opposite ( 18 ). Usually, prevalence is lower in women predominantly at earlier disease stages, whereas disease frequency increases in postmenopausal women ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Risk predictors of advanced hepatic fibrosis in patients with nonalcoholic fatty liver disease – a survey in a university hospital in Brazil

Andrade¹,

Xavier²,

Souza³

et al. 2022

Archives of Endocrinology and Metabolism

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Objective: Describe the clinical profile of patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) and analyze the risk predictors of hepatic fibrosis in outpatient follow-up at a university hospital. Subjects and methods: Demographic, clinical and laboratory data of a cohort of 143 patients with biopsy-proven NAFLD were retrospectively analysed under univariate analyses. Diagnostic accuracy, determined by AUROC, was evaluated for variables that showed a significant difference in univariate comparison analysis and diagnostic performances were determined by sensitivity and specificity. Results: The mean age of studied patients were 48 years, 66.4% of them were women. Age, presence of diabetes mellitus, hypertension, metabolic syndrome and laboratory variables such as AST/ALT ratio, GGT, platelet count and fasting glucose were significantly associated with advanced fibrosis. FIB-4 and NAFLD fibrosis score (AUROC 0.82 and 0.89, respectively) outperformed APRI (AUROC 0.73) for advanced liver fibrosis and cirrhosis (P of 0.04). Conclusion: In our study, metabolic syndrome, diabetes, hypertension, AST/ALT ratio, GGT, platelet count and fasting glucose were associated with hepatic fibrosis in patients with NAFLD. The non-invasive tests FIB-4 and NAFLD fibrosis score showed the best accuracy to stratify disease severity.

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Nonalcoholic fatty liver disease and obesity

Abstract: Nonalcoholic fatty liver disease is strongly related with obesity.

Cited by 15 publications

References 31 publications

Comparison of Hepatic Profile in Pre and Postoperative of Bariatric Surgery: Private vs Public Network

Comparison of Hepatic Profile in Pre and Postoperative of Bariatric Surgery: Private vs Public Network

Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients

Risk predictors of advanced hepatic fibrosis in patients with nonalcoholic fatty liver disease – a survey in a university hospital in Brazil

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