Peritoneostomy with latex coated polypropylene: experimental study in rats

PURPOSE:To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia. METHODS:Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro ® mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes. RESULTS:No significant difference was seen among groups in adherences, fibrosis, giant cells, macrophages, neutrophils or lymphocytes (p>0.05). Mesh shrinkage was observed in all groups, but also no difference was observed between polypropylene and Ultrapro mesh (7.0±9.9 vs. 7.4±10.1, respectively, p=0.967). Post-operatory complications included fistula, abscess, dehiscence, serohematic collection and reherniation, but with no difference among groups (p=0.363). CONCLUSION:There is no difference between polypropylene (high-density) and Ultrapro ® (low-density) meshes at 21 days after surgery in extraperitoneal use in rats, comparing inflammatory response, mesh shortening, adhesions or complications.

show abstract

“…These studies also reported a higher incidence of fibrosis, adhesions, and fistula compared to light-weight meshes 11 .…”

Section: ®3mentioning

confidence: 86%

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Utiyama

Rosa²,

Andres³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Postoperative adhesions represent a complex problem after the manipulation of the abdominal cavity 2 3 10 14 28 or situations that are accompanied by peritonitis 8 . Environmental factors such as smoking, factors that are inherent to the patient as obesity and genetics, as well as local complications of the incision, with wound infection, are important to the development of incisional hernias 13 15 26 .…”

Section: Discussionmentioning

confidence: 99%

“…Aydos et al 7 , during the initial phase of their study in rabbits, only performed the opening of the linea alba, but modified the experimental model and opted for eversion of the edge of the incision because one of their animals had a strangulated hernia with necrosis of the cecum and enterocutaneous fistula. Claudio et al 10 , studying a large number of animals for a longer period (90 rats - 45 days), reported nine deaths due to enteric fistulas and three due to intestinal obstruction following the implantation of different prostheses. Concerning this study, was lost one animal in the second phase, after implantation of the prosthesis, due to injury of intestinal loop by the suture, with fistula, peritonitis and death of the animal caused by technical fault.…”

Section: Discussionmentioning

confidence: 99%

“…Aramayo et al 4 used the correct denomination and although Aydos et al 7 have also produced incisional hernias experimentally, their aim was to perform videolaparoscopy surgery, not to correct the condition. Some authors accurately used the term "peritoneostomy" 10 12 , a possible option, but a large number of articles incorrectly describe "incisional hernia" for situations in which the opening of the cavity or the resection of a fragment of the wall, with various shapes and sizes, is primarily corrected 6 9 19 24 25 29 30 .…”

Section: Discussionmentioning

confidence: 99%

“…Biomaterial implants in the abdominal wall allowed the development of classical experimental models for the study of its biocompatibility. They can be basically divided on: 1) those which an incision is made with standard size on the linea alba and its repair is made with different prostheses in the first operation 11 19 21 ; 2) on those that resect fragments with various formats of the wall 9 22 23 30 and also perform primary repair 1 10 29 ; and on 3) those whose model is similar to the usual clinical condition, initially producing an incisional hernia, with its subsequent correction 4 . The focus of these studies is the consequence of the synthetic implants directly in contact with the abdominal viscera, a topic that has gained importance with the development of laparoscopy as an option for treating ventral hernias 5 16 18 25 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Critical Analysis of Experimental Model for Study of Adhesions After Incisional Hernias Induced in Rats’ and Repair of Abdominal Wall With Different Biomaterials

Serigiolle¹,

Barbieri²,

Gomes³

et al. 2015

ABCD, arq. bras. cir. dig.

View full text Add to dashboard Cite

Background: Adhesions induced by biomaterials experimentally implanted in the abdominal cavity are basically studied by primary repair of different abdominal wall defects or by the correction of incisional hernias previously performed with no precise definition of the most appropriate model. Aim: To describe the adhesions which occur after the development of incisional hernias, before the prosthesis implantation, in an experimental model to study the changes induced by different meshes. Methods: Incisional hernias were performed in 10 rats with hernia orifices of standardized dimensions, obtained by the median incision of the abdominal wall and eversion of the defect edges. Ten days after the procedure adhesions of abdominal structures were found when hernias were repaired with different meshes. Results: The results showed hernia sac well defined in all rats ten days after the initial procedure. Adhesions of the greater omentum occurred in five animals of which two also showed adhesions of small bowel loops besides the omentum, and another two showed liver adhesions as well as the greater omentum, numbers with statistical significance by Student's t test (p<0.05). Conclusion: Although it reproduces the real clinical situation, the choice of experimental model of incisional hernia repair previously induced implies important adhesions, with possible repercussions in the evaluation of the second operation, when different implants of synthetic materials are used.

show abstract

META Score: An International Consensus Scoring System on Mesh‐Tissue Adhesions

et al. 2020

View full text Add to dashboard Cite

Background Currently, the lack of consensus on postoperative mesh-tissue adhesion scoring leads to incomparable scientific results. The aim of this study was to develop an adhesion score recognized by experts in the field of hernia surgery. Methods Authors of three or more previously published articles on both mesh-tissue adhesion scores and postoperative adhesions were marked as experts. They were queried on seven items using a modified Delphi method. The items concerned the utility of adhesion scoring models, the appropriateness of macroscopic and microscopic variables, the range and use of composite scores or subscores, adhesion-related complications and follow-up length. This study comprised two questionnaire-based rounds and one consensus meeting. Results The first round was completed by 23 experts (82%), the second round by 18 experts (64%). Of those 18 experts, ten were able to participate in the final consensus meeting and all approved the final proposal. From a total of 158 items, consensus was reached on 90 items. The amount of mesh surface covered with adhesions, tenacity and thickness of adhesions and organ involvement was concluded to be a minimal set of variables to be communicated separately in each future study on mesh adhesions. Conclusion The MEsh Tissue Adhesion scoring system is the first consensus-based scoring system with a wide backing of renowned experts and can be used to assess mesh-related adhesions. By including this minimal set of variables in future research interstudy comparability and objectivity can be increased and eventually linked to clinically relevant outcomes.

show abstract

Peritoneostomy with latex coated polypropylene: experimental study in rats

Cited by 4 publications

References 20 publications

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Critical Analysis of Experimental Model for Study of Adhesions After Incisional Hernias Induced in Rats’ and Repair of Abdominal Wall With Different Biomaterials

META Score: An International Consensus Scoring System on Mesh‐Tissue Adhesions

Contact Info

Product

Resources

About