Rumo à regulamentação da utilização de animais no ensino e na pesquisa científica no Brasil

Marques, Ruy Garcia; Miranda, Marcos L.; Caetano, Carlos Henrique Soares; Biondo-Simões, Maria de Lourdes Pessole

doi:10.1590/s0102-86502005000300013

Cited by 16 publications

(12 citation statements)

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“…In the city of Rio de Janeiro, legislation has been passed and then repealed. 10 Florianópolis was the first Brazilian city to regulate the use of animals in research and teaching. 11 Despite legislative obstacles, over recent years there has been a growing increase in the number of publications about surgical techniques employing experimental animals.…”

Section: Review Article Introductionmentioning

confidence: 99%

Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental

Damy¹,

Camargo²,

Chammas³

et al. 2010

Rev. Assoc. Med. Bras.

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With the objective of contributing to research in experimental surgery, this article presents an analysis of the principal parameters laid down by Brazilian and international ethics and animal welfare committees and which must be adhered to for publication in international peer-reviewed journals. Standardization of the genetics, sanitary status and environment of the species Mus musculus (mice), Rattus norvegicus (rats), Oryctolagus cuniculus (rabbits) and Sus scropha domesticus (pigs), appropriate transportation, acclimatization, enrichment of the environment, training of animal science technicians, information management, biosafety, diet, anesthesia, postoperative care, analgesia and euthanasia, in combination with well-planned research protocols are presented as the basic elements for achieving results with a high degree of acuity, reproducibility and precision.

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Section: Review Article Introductionmentioning

confidence: 99%

Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental

Damy¹,

Camargo²,

Chammas³

et al. 2010

Rev. Assoc. Med. Bras.

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“…Especially with regard to testing of new drugs for certain diseases, in a way the side effects observed in clinical trials can be mitigated and prevented based on observations from previous in vivo studies. This context highlighted the need to regulate the use of animals in scientific research in Brazil, imposing limits on this practice to eliminate acts of cruelty and maltreatment of animals used in experiments and to promote the improvement of methodological and ethical aspects of scientific studies 12,13 . Thus, Law 11.794, also known as Lei Arouca (Arouca Law), which regulates the procedures for the scientific use of animals 14 was approved in 2008 in Brazil.…”

Section: Use Of Animals In Research: a Brief Review Of Legislation Inmentioning

confidence: 99%

Utilização de animais em pesquisas: breve revisão da legislação no Brasil

Guimarães¹,

Freire

Menezes³

2016

Rev. Bioét.

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The use of animals for scientific purposes is a historical procedure in human civilization, but is controversial for societies concerned with the protection of animals. In Brazil, until 2008, there was no rule or law that specifically regulated animal testing. This paper discusses the use of animals in scientific experiments, considering the Brazilian Arouca Law, through the analysis of scientific articles that consider the history of experimentation in the world and in Brazil, including the regulation of the use of animals of the phylum Chordata, subphylum Vertebrata, in Brazilian research. The Arouca Law may represent an advance in Brazilian law regarding the use of animals for scientific purposes, particularly given the creation of the Ethics Committees for Animal Use in research institutions and the National Council for Animal Experimentation Control, which examine the compliance of scientific projects involving the use of such animals to applicable law. Keywords: Bioethics. Animal technicians-Medical care. Laboratory animal science. Models, animal. Animal use alternatives. Animal experimentation. Resumo Utilização de animais em pesquisas: breve revisão da legislação no BrasilA utilização de animais para fins científicos configura prática histórica na civilização humana, mas gera polêmica em sociedades preocupadas com proteção dos animais. No Brasil, até 2008, não havia norma ou lei que regulamentasse especificamente a experimentação animal. Este trabalho discute a utilização de animais em experimentos científicos, considerando o delineamento da Lei Arouca, por meio da leitura de artigos científicos que contemplam o histórico da experimentação no contexto mundial e brasileiro, incluindo a regulamentação do uso de animais do filo Chordata, subfilo Vertebrata, em pesquisas no Brasil. A Lei Arouca pode representar avanço na legislação brasileira quanto à utilização de animais para fins científicos, sobretudo pela criação das comissões de ética para uso de animais em instituições de pesquisa e do Conselho Nacional de Controle de Experimentação Animal, que examinam o cumprimento da legislação aplicável em projetos científicos que envolvem a utilização de animais. Palavras-chave: Bioética. Técnicos em manejo de animais-Cuidados médicos. Ciência dos animais de laboratório. Modelos animais. Alternativas ao uso de animais. Experimentação animal. ResumenUtilización de animales en la investigación: breve revisión de la legislación en Brasil El uso de animales para fines científicos configura una práctica histórica en la civilización humana, pero genera controversia en las sociedades preocupadas por la protección de éstos. En Brasil, hasta 2008, no había una norma o una ley que regulara la experimentación animal. Este trabajo discute acerca del uso de animales en experimentos científicos, teniendo en cuenta los lineamientos de la Ley Arouca, a partir de la lectura de artículos científicos que abordan la historia de la experimentación animal en el mundo y en el contexto brasilero, incluyendo la regulación del uso...

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“…In this research, as it was an experimental study on live animals, it was essential to have knowledge of all the procedures that are aimed at the well-being and safety of the animal and of the researcher [17][18][19][20] . Therefore, all norms were followed regarding ethical issues related to the proper and responsible handling of the animals.…”

Section: Correlation Between the Inflammatory Intensity And Size Of Tmentioning

confidence: 99%

Effect of the period of extrinsic mechanical compression following sclerotherapy in veins in rabbit ears

Ivo¹,

Ivo

Salles

et al. 2011

Acta Cir. Bras.

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Purpose:Research whether a post-sclerotherapy venous compression period of up to 120 hours is sufficient to avoid reperfusion in treated veins; whether there is a relationship between the inflammatory intensity in venous walls and adjacent tissue and the size of venous thrombosis; whether the intensity of the post-sclerotherapy inflammation varies with the period of compression; whether there is a relationship between the presence of hemosiderin in the tissues adjacent to the sclerosing blood vessels and venous blood clots. Methods: Twenty eight rabbits, all male, were utilized, distributed into four groups (0, 24, 72 and 120). All the animals were administered with 0.25 ml of 1% polidoconal solution and, as a control, 0.25 ml of 0.9% sodium chloride solution in the marginal dorsal vein of the right and left ears, respectively. Mechanical compression was applied to the perfused stretch of the vein, except for the animals in group 0. The period of compression varied from 0 to 120 hours in the groups. An anatomopathological examination of the section of the right and left marginal dorsal veins of all the animals was conducted. Results: There was no significant difference among the various compression periods, both in terms of the degree of vein thrombosis and in the inflammatory intensity in both ears of the various groups. A positive and significant correlation was observed between the inflammatory intensity and the size of the thrombus and in the occurrence of thrombi and hemosiderin. Conclusions: A compression period of up to 120 hours is not sufficient to prevent reperfusion in sclerosing blood vessels. The intensity of tissue inflammation is related to the size of the thrombus, but not to the compression period. The presence of hemosiderin in the tissues adjacent to the vessels subjected to sclerosis is related to the presence of venous coagulation. Key words: Sclerotherapy. Sclerosing Solutions. Varicose Veins. Animal Experimentation. Academic Dissertations. Rabbits. RESUMOObjetivo: Pesquisar se o tempo de compressão venosa de até 120 horas pós-escleroterapia é suficiente para evitar reperfusão nas veias tratadas; se há relação entre a intensidade inflamatória na parede venosa e tecidos adjacentes e o tamanho do trombo venoso; se a intensidade da inflamação pós-escleroterapia varia com o tempo de compressão; se há relação entre a presença de hemossiderina nos tecidos adjacentes ao vaso esclerosado e coágulo venoso. Métodos: Utilizaram-se 28 coelhos, machos, distribuídos em quatro grupos (0, 24, 72 e 120). Em todos os animais foram administrados 0,25 ml de solução de polidocanol 1% e, como controle, 0,25 ml de solução de cloreto de sódio 0,9% na veia marginal dorsal das orelhas direita e esquerda, respectivamente. Realizou-se compressão mecânica em trecho da veia perfundida, exceto nos animais do grupo 0. O tempo de compressão variou de 0 a 120 horas nos grupos. Realizou-se exame anatomopatológico de trecho das veias marginais dorsais direita e esquerda de todos os animais. Resultados: Não houve dife...

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Rumo à regulamentação da utilização de animais no ensino e na pesquisa científica no Brasil

Abstract: In our country there is not regimentation for using animals in teaching and in scientific research. It becomes imperative to make lucid and realistic arrangements which can assure the continuity of the use of animals. The scientific community is ready to contribute to that purpose.

Cited by 16 publications

References 0 publications

Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental

Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental

Utilização de animais em pesquisas: breve revisão da legislação no Brasil

Effect of the period of extrinsic mechanical compression following sclerotherapy in veins in rabbit ears

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