Efeito da solução de ácido acetilsalicílico e de ácido acético em fígado de coelhos

Saad-Hossne, Rogério; Prado, Renê Gamberini; Hossne, William Saad

doi:10.1590/s0102-86502004000600016

Cited by 7 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ohnishi et al 11 found the same lesions using acetic acid on liver and Saad-Hossne et al 7 also found coagulative necrosis on liver of rabbits after the injection of acetic acid and aspirin. In a common pattern of cell death caused by oxygen loss, the necrotic cells…”

Section: Discussionmentioning

confidence: 82%

“…In our research group, we had the opportunity to study and scientifically prove cytolytic effects of aspirin (acetylsalicylic acid) and its derivatives, either in vitro or in vivo on several experimental models [6][7][8][9][10] . Following this line of research, the purpose of this experimental study was to evaluate the effects of aspirin on normal lymph nodes of rabbits as basis for its later use on lymph nodes affected by tumor.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases

Batista¹,

Denadai²,

Saad-Hossne

2012

Acta Cir. Bras.

Self Cite

View full text Add to dashboard Cite

Brazil. Supervised all phases of the study; conception, design, intellectual and scientific content of the study; manuscript writing; critical revision. ABSTRACT PURPOSE:To evaluate the effects of aspirin 10% and 20% on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases. METHODS: A total of 20 lymph nodes from 20 rabbits (randomized in four groups) were evaluated. Aspirin solutions 10% (groups A and C) and 20% (groups B and D) were injected into mesenteric lymph nodes of healthy rabbits and had its gross and histological effects evaluated at 24 hours (groups A and B) and at seven days (groups C and D). RESULTS:In the groups A and B evaluated at 24 hours it was observed extensive necrosis and hemorrhage, a significant increase in apoptosis throughout the lymph node with medullary sinuses enlargement and an increase in germinal centers. In the groups C and D evaluated at seven days of solution injection there was also an increase in apoptosis with higher elevation of histiocytes and a significant decrease of necrosis and an increase of giant cells was noticed causing a foreign body chronic inflammation. In all comparisons, there were no differences between the concentrations used (10 and 20%). CONCLUSIONS: The injection of aspirin on lymph nodes caused necrosis and an increase of apoptosis after 24 hours and after seven days of treatment there was regeneration of the lymph nodes, with intense decrease of necrosis and a great elevation of apoptosis. These experimental results support future clinical studies on application of aspirin in the treatment of lymphatic metastases, since the increase of apoptosis is one of the pillars of cancer therapy. Key words: Aspirin. Lymph Nodes. Neoplasm Metastasis. Apoptosis. Therapeutics. Rabbits. RESUMOOBjETIvO: Avaliar os efeitos do ácido acetilsalicílico a 10% e 20% em linfonodos mesentéricos de coelhos para posterior embasamento e uso em metástases linfonodais. MéTODOS: Um total de 20 linfonodos de 20 coelhos (divididos aleatoriamente em quatro grupos) foi avaliado. As soluções de aspirina a 10% (grupos A e C) e 20% (grupos B e D) foram injetadas em linfonodos mesentéricos de coelhos sadios e seus efeitos macroscópicos e histológicos foram avaliados em 24 horas (grupos A e B) e em sete dias (grupos C e D). RESULTADOS: Nos grupos avaliados em 24 horas (A e B) foi verificada intensa necrose e hemorragia, aumento importante de apoptose em todo o linfonodo, com alargamento dos seios medulares e aumento dos centros germinativos. Nos grupos avaliados em sete dias (C e D) também houve aumento da apoptose, com maior elevação de histiócitos e diminuição importante da necrose; a hemorragia foi ausente e aumento de células gigantes foi visualizado, conferindo processo inflamatório crônico do tipo corpo estranho. Não houve diferença entre as concentrações utilizadas (10 e 20%) em nenhuma das comparações. CONCLUSÕES: A injeção de aspirina em linfonodos causou necrose e um aumento de apoptose após 24 horas e após sete dias de tratamento, houve regeneração dos g...

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases

Batista¹,

Denadai²,

Saad-Hossne

2012

Acta Cir. Bras.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this context, it is of paramount importance to acknowledge the definite need for the development of new drugs to provide specific and more efficient therapeutic alternatives to completely eliminate endometriotic lesions, prevent recurrences, and has none or low side effects 6 . Therefore, based on our previously tested different doses and periods of time in other experimental rabbit models [7][8][9][10][11] , the present study was delineated to evaluate whether a higher aspirin concentration and longer follow-up of outcomes (namely, 20% aspirin and 20 days after intralesional injection, respectively) could positively impact on completely reducing peritoneal endometrial tissue.…”

Section: Gross and Histological Measurementsmentioning

confidence: 99%

“…Over the last decade, our research group [7][8][9][10][11][12] Therefore, the present study assessed the therapeutic efficacy of intralesional 20% aspirin injection using the wellestablished peritoneal endometriosis rabbit model.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…16,24,25 Since cis-diamminedichloroplatinum(II) (cis-DDP) emerged as the mostly employed antitumour metal-drug, 9 many novel complexes containing metals of platinum group are being investigated.…”

Section: Biological Activitiesmentioning

confidence: 99%

Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour

Rocha¹,

Santana²,

Ananias³

et al. 2007

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Os ciclometalados de paládio(II) são compostos inorgânicos reativos empregados em vários estudos biológicos devido a seu potencial antitumoral e interação com o sistema imune. Neste estudo, a resposta imune e citotóxica induzida por dois complexos organopaladados: [{Pd(N,C-dmba)} 2 (μ-NCS) 2 ] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N'-dimetilbenzilamina, dppp = 1,3-bis(difenilfosfino)propano] e cisplatina (cis-DDP), como padrão, foram investigados em camundongos portadores do tumor ascítico de Ehrlich. Os camundongos foram divididos em cinco grupos e inoculados com (1) ou (2) ou cis-DDP ou apenas veículo ou solução salina tamponada de fosfatos (PBS). Diversos parâmetros foram avaliados, tais como a porcentagem de células tumorais presentes no exsudato peritoneal, os níveis de óxido nítrico (NO) e fator de necrose tumoral (TNF-α) séricos e o aumento na expectativa de vida. Os dados obtidos demonstram que o composto (2) apresentou atividade similar à da cis-DDP, como, por exemplo, aumento na expectativa de vida, diminuição dos níveis séricos de TNF-α e aumento da produção de NO.Cyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)} 2 (μ-NCS) 2 ] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N'-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphatebuffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-α and increase in NO production.Keywords: palladium(II) complexes, Ehrlich ascites tumour, macrophages, nitric oxide, tumour necrosis factor-alpha. IntroductionCancer is a disease in which unremitting clonal expansion of somatic cells kills by invading, subverting, and eroding normal tissues. 1 Millions of people die every year from the metastatic spread of cancer that occurs through blood and lymphatic vessels or directly into tissues and body cavities. 2 Between the several types of cancer, breast cancer is the most common malignancy in women worldwide. 3 In some cases, immune cells constitute a prominent component of the host response to cancer, but their participation in tumour pathogenesis remains not completely understood. Dense intratumoral lymphocyte cis-Diamminedichloroplatinum(II), 9 a clinically important antitumour drug, acts like a classical alkylating agent in chemotherapy against some types of cancers. It is a potent ...

show abstract

Efeito da solução de ácido acetilsalicílico e de ácido acético em fígado de coelhos

Cited by 7 publications

References 3 publications

Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases

Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases

Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits

Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour

Contact Info

Product

Resources

About