Estudo dos lipídios em jovens portadores de esquistossomose hepatoesplênica submetidos a tratamento cirúrgico

Silva, Schirley Nóbrega da; Oliveira, Keyla Fontes de; Brandt, Carlos Teixeira; Lima, Vera Lúcia de Menezes

doi:10.1590/s0102-86502002000400010

Cited by 3 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Risk association analysis indicated that schistosomiasis was a protective factor against increased plasma levels of TRI and CHO in this age group. According to Silva et al 36 , abnormalities in lipid metabolism are commonly seen in the hepatosplenic form of schistosomiasis, particularly decreased total cholesterol, TRI and HDL levels. Experimental studies have shown that schistosomal infection inhibits atherosclerosis in addition to reducing total cholesterol levels in mice 37,38 , which may be explained by the fact that S. mansoni is unable to synthesize cholesterol required for growth and egg production 39 .…”

Section: Discussionmentioning

confidence: 99%

Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni

Silva¹,

Del-Rei

Fraga

et al. 2018

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Portal hypertension and periportal fibrosis commonly occur in severe Schistosoma mansoni infection. Changes in lipid profile and elevated levels of circulating liver enzymes have also been described in infected individuals. The present study sought to assess the alterations in laboratory parameters associated with liver disorder in individuals infected by S. mansoni who visited a private routine laboratory service. Levels of circulating liver enzymes (gamma-glutamyl transferase [γ-GT], aspartate transaminase [AST], alanine transaminase [ALT], and alkaline phosphatase [ALP]) and a lipid panel (total cholesterol [COL], high-density lipoprotein [HDL], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL], and triglycerides [TRI]) were evaluated in both infected and non-infected individuals and relative risk was used to measure associations. Methods: Data were collected for analysis from a total of 1,078 cases identified in 379,600 individuals who submitted samples to the Datalab Laboratory (Salvador, Bahia) between 2004 and 2008. Results: S. mansoni infection led to increased circulating levels of γ-GT in both women and men, AST (women), and ALP (men). S. mansoni infection was a protective factor against increased levels of TRI, CHO, and VLDL for individuals aged 19 years or older. The results of our analysis indicate that alterations in lipid metabolism and circulating liver enzymes in asymptomatic S. mansoni-infected individuals might be attributed to eggs lodged in the hepatic sinusoids. Conclusions: Parasitological testing for S. mansoni should be indicated in endemic areas when this pattern of alterations is detected.

show abstract

Section: Discussionmentioning

confidence: 99%

Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni

Silva¹,

Del-Rei

Fraga

et al. 2018

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

Isoforms of Hsp70-binding human LDL in adult Schistosoma mansoni worms

et al. 2015

View full text Add to dashboard Cite

Schistosoma mansoni is one of the most common parasites infecting humans. They are well adapted to the host, and this parasite's longevity is a consequence of effective escape from the host immune system. In the blood circulation, lipoproteins not only help to conceal the worm from attack by host antibodies but also act as a source of lipids for S. mansoni. Previous SEM studies showed that the low-density lipoprotein (LDL) particles present on the surface of adult S. mansoni worms decreased in size when the incubation time increased. In this study, immunocytochemical and proteomic analyses were used to locate and identify S. mansoni binding proteins to human plasma LDL. Ultrathin sections of adult worms were cut transversely from the anterior, medial and posterior regions of the parasite. Immunocytochemical experiments revealed particles of gold in the tegument, muscle region and spine in male worms and around vitelline cells in females. Immunoblotting and 2D-electrophoresis using incubations with human serum, anti-LDL antibodies and anti-chicken IgG peroxidase conjugate were performed to identify LDL-binding proteins in S. mansoni. Analysis of the binding proteins using LC-MS identified two isoforms of the Hsp70 chaperone in S. mansoni. Hsp70 is involved in the interaction with apoB in the cytoplasm and its transport to the endoplasmic reticulum. However, further studies are needed to clarify the functional role of Hsp70 in S. mansoni, mainly related to the interaction with human LDL.

show abstract

Atherogenesis: Diseases that May Affect the Natural History “Schistosomiasis and HIV Infection”

Brandt¹,

Godoi²,

Valença³

et al. 2013

Current Trends in Atherogenesis

View full text Add to dashboard Cite

Estudo dos lipídios em jovens portadores de esquistossomose hepatoesplênica submetidos a tratamento cirúrgico

Cited by 3 publications

References 8 publications

Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni

Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni

Isoforms of Hsp70-binding human LDL in adult Schistosoma mansoni worms

Atherogenesis: Diseases that May Affect the Natural History “Schistosomiasis and HIV Infection”

Contact Info

Product

Resources

About