Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni

Abstract

Introduction: Portal hypertension and periportal fibrosis commonly occur in severe Schistosoma mansoni infection. Changes in lipid profile and elevated levels of circulating liver enzymes have also been described in infected individuals. The present study sought to assess the alterations in laboratory parameters associated with liver disorder in individuals infected by S. mansoni who visited a private routine laboratory service. Levels of circulating liver enzymes (gamma-glutamyl transferase [γ-GT], aspartate transaminase [AST], alanine transaminase [ALT], and alkaline phosphatase [ALP]) and a lipid panel (total cholesterol [COL], high-density lipoprotein [HDL], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL], and triglycerides [TRI]) were evaluated in both infected and non-infected individuals and relative risk was used to measure associations. Methods: Data were collected for analysis from a total of 1,078 cases identified in 379,600 individuals who submitted samples to the Datalab Laboratory (Salvador, Bahia) between 2004 and 2008. Results: S. mansoni infection led to increased circulating levels of γ-GT in both women and men, AST (women), and ALP (men). S. mansoni infection was a protective factor against increased levels of TRI, CHO, and VLDL for individuals aged 19 years or older. The results of our analysis indicate that alterations in lipid metabolism and circulating liver enzymes in asymptomatic S. mansoni-infected individuals might be attributed to eggs lodged in the hepatic sinusoids. Conclusions: Parasitological testing for S. mansoni should be indicated in endemic areas when this pattern of alterations is detected.

ApoE deficiency promotes hepatic pathology by aggravating Th17/Treg imbalance in murine schistosomiasis japonica

“…One previous research has proved that infection of S mansoni has a protective factor against increased levels of lipid in infected individuals. 7 Our results agreed with this previous publication, and the mechanism needs to be further clarified.…”

“…A growing number of studies have focused on the mutual relationship between Schistosoma infections and metabolic diseases. 7,[24][25][26][27] Most researchers are studying on effect of Schistosoma on metabolic diseases. [28][29][30] However, effects of metabolic disorders on Schistosoma and regulation of immune response in many diseases.…”

“…A growing number of studies have focused on the mutual relationship between Schistosoma infections and metabolic diseases 7,24‐27 . Most researchers are studying on effect of Schistosoma on metabolic diseases 28‐30 .…”

“…The liver is a central hub for lipid metabolism, which can synthesize and release various lipoprotein and lipid metabolism enzymes, and thus affect the balance of lipid metabolism 3,4 . Increasing findings indicate that Schistosoma infection is associated with lipid metabolism disorder 5‐8 …”

Hepatosplenic Protective Actions of Spirulina platensis and Matcha Green Tea Against Schistosoma mansoni Infection in Mice via Antioxidative and Anti-inflammatory Mechanisms

“…mansoni infection causes hepatocellular injury and increases the circulating levels of hepatic enzymes, such as ALT and AST. In addition, it impairs protein synthesis (37). In our mouse model, the circulating levels of AST and ALT were significantly increased, whereas the total protein, albumin, and globulins were decreased after S. mansoni infection.…”