Estudo Da Fosfatase Alcalina Em Ratos Cirróticos Hepatectomizados Após Aplicação De Laser

Lima, A. A. L. de Araujo; Ramalho, Leandra Naíra Zambelli; Zucoloto, S; Bagnato, V. S.; Junior, Oliveira

doi:10.1590/s0102-86502001000500006

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The effect of TLBP on hepatic regeneration after HP stimulates a significant improvement of hepatic regeneration, favorable for the formation of new hepatocytes, mesenchymal stem cells and angiogenesis in regeneration in rats 22 , improving the stability of mitochondrial function, increasing the rate of respiratory control, suggesting delay of hepatocellular overload of the remaining liver 4 , 7 . TLBP can lead to good clinical performance, simple, fast and easy to perform, promoting an improvement in the regenerative capacity of the organ after HP, by increasing the expression of the hepatocyte growth factor, exerting an accelerating role in the process of liver regeneration in rats, regardless of the penetration depth of the laser 3 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Godoy

Gerson

Pinto

et al. 2017

ABCD, arq. bras. cir. dig.

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Background: Partial hepatectomy is a surgical intervention of the liver that can trigger its regenerative process, where the residual lobes deflagrate a compensatory hyperplasia, causing its restoration almost to the original volume. Nevertheless, depending on the extent of liver damage its regeneration might be impaired. The low-power laser has been studied with beneficial results. Aim: To investigate the possible functional and mutagenic damage arising from the use of low-power laser used in liver regeneration after partial hepatectomy. Methods: Fifteen male adult Wistar rats were hepatectomizated in 70% and laser irradiated or not with dose of 70 J/cm2, 650 nm, 100 mW, directly on the remaining liver, during the perioperative period. These animals were divided into four groups: G1 (control, 7 days); G2 (laser, 7 days); G3 (control, 14 days); G4 (laser, 14 days). Were analyzed the liver weight; number of hepatocytes; deposition of collagen fibers; liver function tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, bilirubin and micronucleus test in peripheral blood erythrocyte. Results: The liver weight was greater in G3 and G4 (p=0.001 and p=0.002) compared to other groups. The deposition of collagen fibers in G1 was statistically higher than the other groups (p=0.01). In tests of liver function and micronucleus test was not found significant differences between the studied groups. Conclusion: Low-power laser stimulation did not cause loss of liver function or mutagenic damage.

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Section: Introductionmentioning

confidence: 99%

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Godoy

Gerson

Pinto

et al. 2017

ABCD, arq. bras. cir. dig.

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Avaliação estereológica da microestrutura do fígado em animais desnutridos e submetidos à renutrição protéica

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Alterações da função hepática de camundongos desnutridos e infectados pelo Schistosoma mansoni

Couto

Vieira

Barbosa

et al. 2008

Rev. Soc. Bras. Med. Trop.

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RESUMOExistem poucos estudos sobre as alterações da função hepática em camundongos com esquistossomose associada à desnutrição. Neste trabalho, os animais foram divididos em quatro grupos, de acordo com as dietas (normal ou hipoprotéica) e infectados ou não pelo Schistosoma mansoni. Todos os grupos desenvolveram-se menos que o grupo controle (p<0,0001). A mortalidade nos animais foi devida à infecção. Níveis altos de aminotransferases nos animais nutridos e infectados sugerem um processo inflamatório intenso (p<0,0001). Todos os grupos apresentaram elevação da fosfatase alcalina. Houve aumento da aspartato transferase e da fosfatase alcalina em animais nutridos infectados. As dietas modificaram os níveis de albumina (p>0,001), e das proteínas séricas. Os grupos, comparados ao controle, mostraram baixos níveis de glicose (p<0,001). Este estudo verificou que ambas, infecção e/ou desnutrição, interferiram nos níveis dos indicadores bioquímicos, mas as alterações mais importantes da função hepática ocorreram durante a inflamação intensa causada pela esquistossomose. Palavras-chaves:Esquistossomose. Desnutrição. Função hepática. Camundongos. ABSTRACTThere are few studies on liver function abnormalities in mice with schistosomiasis associated with malnutrition. In this study, animals were divided into four groups, according to their diet (normal or low protein) and whether they were infected with Schistosoma mansoni or not. All the groups grew slower than the control did (p < 0.0001). Mortality among the animals occurred because of the infection. High levels of aminotransferases in well-fed animals with infection suggested that there was an intensive inflammatory process (p < 0.0001). All the groups presented high levels of alkaline phosphatase. There were increases in aspartate transferase and alkaline phosphatase in infected well-fed animals. The diets modified the albumin levels (p > 0.001) and the serum proteins. Compared with the controls, the groups showed low levels of glucose (p < 0.001). This study found that both infection and malnutrition interfered with the biochemical indicator levels, but the most important liver function abnormalities occurred during the intense inflammation caused by schistosomiasis. Há cerca de 6,3 milhões de portadores de esquistossomose no Brasil 16 . A evolução da doença e suas manifestações clínicas são influenciadas por fatores tais como a carga parasitária e a condição nutricional do indivíduo 7 . A esquistossomose está quase sempre associada à desnutrição, porque incide com freqüência na parcela populacional menos favorecida economicamente. Na desnutrição, a deterioração fisiológica está em consonância com seu grau 13 e o fígado, órgão central no metabolismo, tornase quase sempre afetado. Foi observado que a deficiência energético-protéica afeta os sistemas, de modo que, concomitante ao progresso da doença, sobrevém a deterioração das funções hepáticas, com aumento de aminotransferases no soro 14 . KeyNa esquistossomose mansônica (EM), as alterações hepáticas são as manifestaçõ...

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Estudo Da Fosfatase Alcalina Em Ratos Cirróticos Hepatectomizados Após Aplicação De Laser

Cited by 3 publications

References 3 publications

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Avaliação estereológica da microestrutura do fígado em animais desnutridos e submetidos à renutrição protéica

Alterações da função hepática de camundongos desnutridos e infectados pelo Schistosoma mansoni

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