Alterações da função hepática de camundongos desnutridos e infectados pelo Schistosoma mansoni

Abstract

RESUMOExistem poucos estudos sobre as alterações da função hepática em camundongos com esquistossomose associada à desnutrição. Neste trabalho, os animais foram divididos em quatro grupos, de acordo com as dietas (normal ou hipoprotéica) e infectados ou não pelo Schistosoma mansoni. Todos os grupos desenvolveram-se menos que o grupo controle (p<0,0001). A mortalidade nos animais foi devida à infecção. Níveis altos de aminotransferases nos animais nutridos e infectados sugerem um processo inflamatório intenso (p<0,0001). Todos os grupos apresentaram elevação da fosfatase alcalina. Houve aumento da aspartato transferase e da fosfatase alcalina em animais nutridos infectados. As dietas modificaram os níveis de albumina (p>0,001), e das proteínas séricas. Os grupos, comparados ao controle, mostraram baixos níveis de glicose (p<0,001). Este estudo verificou que ambas, infecção e/ou desnutrição, interferiram nos níveis dos indicadores bioquímicos, mas as alterações mais importantes da função hepática ocorreram durante a inflamação intensa causada pela esquistossomose. Palavras-chaves:Esquistossomose. Desnutrição. Função hepática. Camundongos. ABSTRACTThere are few studies on liver function abnormalities in mice with schistosomiasis associated with malnutrition. In this study, animals were divided into four groups, according to their diet (normal or low protein) and whether they were infected with Schistosoma mansoni or not. All the groups grew slower than the control did (p < 0.0001). Mortality among the animals occurred because of the infection. High levels of aminotransferases in well-fed animals with infection suggested that there was an intensive inflammatory process (p < 0.0001). All the groups presented high levels of alkaline phosphatase. There were increases in aspartate transferase and alkaline phosphatase in infected well-fed animals. The diets modified the albumin levels (p > 0.001) and the serum proteins. Compared with the controls, the groups showed low levels of glucose (p < 0.001). This study found that both infection and malnutrition interfered with the biochemical indicator levels, but the most important liver function abnormalities occurred during the intense inflammation caused by schistosomiasis. Há cerca de 6,3 milhões de portadores de esquistossomose no Brasil 16 . A evolução da doença e suas manifestações clínicas são influenciadas por fatores tais como a carga parasitária e a condição nutricional do indivíduo 7 . A esquistossomose está quase sempre associada à desnutrição, porque incide com freqüência na parcela populacional menos favorecida economicamente. Na desnutrição, a deterioração fisiológica está em consonância com seu grau 13 e o fígado, órgão central no metabolismo, tornase quase sempre afetado. Foi observado que a deficiência energético-protéica afeta os sistemas, de modo que, concomitante ao progresso da doença, sobrevém a deterioração das funções hepáticas, com aumento de aminotransferases no soro 14 . KeyNa esquistossomose mansônica (EM), as alterações hepáticas são as manifestaçõ...

Oral Kefir Grains Supplementation Improves Metabolism and Liver Antioxidant Enzymes Expression in Malnourished Mice

“…Liver damage caused by malnutrition due to food restriction has already been described by other studies [19], mainly because the liver is a central organ in metabolism [20]. In the present study, we demonstrated that malnutrition generates liver damage.…”

Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide

“…Chronic Infection (CI) caused by A. cantonensis increased the activity of ALP in the blood of rodents, suggesting cholestasis. Garcia et al [20] proposed that infection by A. cantonensis impairs bile flow and solubilization of this enzyme in hepatocyte membranes, and consequently increases serum availability [32,37]. Furthermore, it has been postulated that liver tissue damage caused by helminth infection may result in cytolysis of hepatocytes, resulting from cell membrane damage and enzyme release into the bloodstream [20].…”

THE RELEVANCE OF NUTRITIONAL STATUS AND HISTOPATHOLOGICAL FINDINGS ON THE INFECTIOUS PROCESS OF BALB/C MICE INOCULATED WITH Lacazia loboi

“…The liver and spleen have a significant role in both the nutritional and infectious processes. In PCM, histological changes, as well as the weight of these organs may reflect nutritional changes 5 , 16 . In the present study, the weight of the liver and spleen of the malnourished group showed a significantly reduction when compared to groups without food restriction, as described earlier in the literature related to other pathologies 4 , 5 , 25 .…”

“…The study of COUTO et al . 5 , about changes on the liver function in mice with schistosomiasis associated with malnutrition showed that both infection and/or malnutrition interfered in the levels of hepatic biochemical indicators, but the most important changes in liver function occurred during the intense inflammatory process caused by schistosomiasis, leading to increased liver enzymes.…”