2008
DOI: 10.1590/s0037-86822008000400013
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Alterações da função hepática de camundongos desnutridos e infectados pelo Schistosoma mansoni

Abstract: RESUMOExistem poucos estudos sobre as alterações da função hepática em camundongos com esquistossomose associada à desnutrição. Neste trabalho, os animais foram divididos em quatro grupos, de acordo com as dietas (normal ou hipoprotéica) e infectados ou não pelo Schistosoma mansoni. Todos os grupos desenvolveram-se menos que o grupo controle (p<0,0001). A mortalidade nos animais foi devida à infecção. Níveis altos de aminotransferases nos animais nutridos e infectados sugerem um processo inflamatório intenso (… Show more

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Cited by 14 publications
(11 citation statements)
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References 12 publications
(8 reference statements)
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“…Liver damage caused by malnutrition due to food restriction has already been described by other studies [19], mainly because the liver is a central organ in metabolism [20]. In the present study, we demonstrated that malnutrition generates liver damage.…”
Section: Discussionsupporting
confidence: 83%
“…Liver damage caused by malnutrition due to food restriction has already been described by other studies [19], mainly because the liver is a central organ in metabolism [20]. In the present study, we demonstrated that malnutrition generates liver damage.…”
Section: Discussionsupporting
confidence: 83%
“…Chronic Infection (CI) caused by A. cantonensis increased the activity of ALP in the blood of rodents, suggesting cholestasis. Garcia et al [20] proposed that infection by A. cantonensis impairs bile flow and solubilization of this enzyme in hepatocyte membranes, and consequently increases serum availability [32,37]. Furthermore, it has been postulated that liver tissue damage caused by helminth infection may result in cytolysis of hepatocytes, resulting from cell membrane damage and enzyme release into the bloodstream [20].…”
Section: Discussionmentioning
confidence: 99%
“…The liver and spleen have a significant role in both the nutritional and infectious processes. In PCM, histological changes, as well as the weight of these organs may reflect nutritional changes 5 , 16 . In the present study, the weight of the liver and spleen of the malnourished group showed a significantly reduction when compared to groups without food restriction, as described earlier in the literature related to other pathologies 4 , 5 , 25 .…”
Section: Discussionmentioning
confidence: 99%
“…The study of COUTO et al . 5 , about changes on the liver function in mice with schistosomiasis associated with malnutrition showed that both infection and/or malnutrition interfered in the levels of hepatic biochemical indicators, but the most important changes in liver function occurred during the intense inflammatory process caused by schistosomiasis, leading to increased liver enzymes.…”
Section: Discussionmentioning
confidence: 99%