Estudo experimental sobre o uso de cianoacrilatos para anastomose intestinal látero-lateral em cães

Abstract

Testamos em 25 cães a aplicação do isobutil-2-cianoacrilato Grupo I=13 e n-butil-<FONT FACE="Symbol">a</font> -cianoacrilato Grupo II=12 para anastomose intestinal látero-lateral. As anastomoses foram avaliadas aos 4, 14 e 28 dias de p.o. Observamos macroscópicamente aderência entre o epiploo e a ferida cirúrgica da parede abdominal em ambos os grupos. Comparando os Grupos I e II através o teste t não pareado, estatisticamente não apresentaram diferença significativa (p=0,3624). Ao exame histológico notamos reação inflamatória, granuloma e no seu interior presença do adesivo.<br>Isobutyl-2-cyanoacrylate (Group I) and n-butyl-<FONT FACE="Symbol">a</font> -cyanoacrylate (Group II) were tested in two groups of dogs: Group I=13 dogs and Group II=12 dogs that had intestinal laterolateral anastomosis.The anastomosis were avaluated on days: 4, 14 and 28 after surgery. Adhesions between omentum and the surgical wall wound were grossly observed in both groups. Regarding the presence of adhesions comparing the two groups with unpaired t test, the difference between Group I and II is not significant (p=0,3624). Histology revealed inflammation and granuloma on the anastomosis with the adhesive inside of it both with isobutyl-2-cyanoacrylate and n-butyl-<FONT FACE="Symbol">a</font> -cyanoacrylate

O etil-2-cianoacrilato como selante após ressecção parcial de ceco em rattus norvegicus albinus

“…This analysis shows mixed results in the literature, the reaction with cyanoacrylate being greater 13 , displaying less granuloma formation 2,11.14 and, alternatvely, showing a similar pattern between the different materials used 9 , which is consistent with our results. Well-formed granulomas may be found in the intestine of animals treated with cyanoacrylate sacrificed on the 28 th postoperative day, but not in 4 th or 14 th POs 10 .…”

“…Moreover, we can state that the tissue reaction was minimal for all groups, given the minimal macroscopic changes observed, which was also homogeneously distributed in the sample groups. These findings are controversial in the literature: Matera et al 10 , in a comparative study between the isobutyl-2-cyanoacrylate and n-butyl-2-cyanoacrylate, found that both compounds caused a similar degree of adhesions.…”

Uso Do Adesivo Etil-Cianoacrilato Em Dermorrafias De Ovinos

“…A fim de evitar interferência da técnica operatória na adesividade do etil-cianoacrilato e consequente descência da ferida, hemostasia foi realizada de forma cuidadosa. Segundo Matera et al (1999) e Mixter (1998), o controle do sangramento é importante durante a aplicação dos cianoacrilatos, uma vez que a presença de sangue afeta a sua capacidade adesiva.…”