Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ataque cardíaco isquêmico agudo

Abstract

Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ataque cardíaco isquêmico agudoSystemic inflammation caused by chronic periodontitis in acute ischemic heart attack patients Abstract Objective: Infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (AIHD).Methods: One hundred one patients with AIHD with and without chronic periodontitis (CP) were included in this study. Patients were admitted to the HC UNICAMP and stratified into three groups: in group 1, we selected patients with severe chronic periodontitis (31 men and 19 women, mean age 55.1 ± 11.29 years old); the group 2 with mild chronic periodontitis (40 men and 28 women, mean age 54.8 ± 10.37 years old) and group 3 represented by the toothless (43 men and 20 women, mean age 67.5 ± 8.55 years old). Blood samples were collected to measure the lipid profiles, hematological and blood glucose levels. In addition, biopsies of seventeen coronary arteries with atherosclerosis and an equal number of internal mammary arteries without atherosclerotic degeneration in group 1 were investigated. Statistical analysis by analysis of variance (ANOVA) and Scheffé test for multiple comparisons was performed.Results: Triglyceride and LDL levels were elevated in group 1 than in group 2. HDL were reduced by 20% in group 1 and remained reduced by 8% in toothless. Blood glucose was higher in group 1. DNA of periodontal bacteria was detected in 58.8% of the coronary arteries.Conclusions: Patients with (AIHD) and severe chronic periodontitis may have altered lipid profile, as well as microorganisms associated with CP can permeate into coronary vessels. Descriptors 52OLIVEIRA, FJ -Systemic inflammation caused by chronic periodontitis in acute ischemic heart attack patients Bras Cir Cardiovasc 2010; 25(1): 51-58 Rev

Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties

“…In sepsis, LPS released from Gram-negative bacteria induces strong immune responses and causes severe complications (48,49). Chronic low level blood LPS has been increasingly appreciated as a link between chronic infectious diseases such as periodontitis and other immune-related chronic inflammatory diseases such as atherosclerosis (50,51). In both acute and chronic cases, LPS-TLR4 signaling-induced proinflammatory cytokine production is the primary pathogenic FIGURE 8.…”

Meaning of the Oral Hygiene in Children, Due to Atherosclerosis Generation

“…This bacterium was not detected in the control group, which suggests that children from this group maintained good oral hygiene. This bacterium, along with Porphyromonas gingivalis and Prevotella intermedia, was also detected in the tunica intima (Marques de Silva et al, 2005) and atherosclerotic plaques (Kozaeov et al, 2005;Oliveira et al, 2010).…”

“…Out of the entire oral flora, the bacteria most closely related to the etiology of periodontitis include Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Prevotella intermedia (Buhlin et al, 2003;Marat, 2008;Oliveira et al, 2010;Accarini and De Codoy, 2006;Fardi and Papadimitriou, 2007;Restaino et al, 2007). Over 55% of patients from the study group (poor oral hygiene) exhibited Aggregatibacter actinomycetemcomitans.…”

Relationship between periodontal disease and hyperlipidemia related to vascular events

“…When reviewing the literature on the relationship between periodontal conditions and the blood levels of lipoproteins in plasma, there are several scientific articles that affirm a positive relationship [37,[50][51][52][53]56]. Including the article by Pejcic et al, (2011) [50] verified that there were not a relationship, and also, a decrease on the lipid level after the periodontal therapy in patients with periodontitis, in a longitudinal study.…”

“…Oliveira et al, (2010) [53] in addition to finding an increase of LDL and TG in patients with vascular diseases, the study also attempt for a presence of oral pathogens in plaques of coronary arteries.…”