Influência do veículo na eficácia da reposição de potássio em ratos hipocalêmicos

Abstract

Influência do veículo na eficácia da reposição de potássio em ratos hipocalêmicosVehicle influence on potassium replacement effectiveness in hypokalemic rats Abstract Introduction: Patients who undergo cardiac surgery are commonly treated with diuretic therapy for the management of volume overload. The concern of hypokalemia in adult before, during and after surgery has already been described since there is risk of cardiac arrhythmia. Clinically, intravenous potassium (K+) replacement dilution is only recommended with sodium chloride 0.9% solution (SF0.9%), likely due to the putative effects of glucose solution 5% (SG5%) on insulin secretion, which influence K+ replacement quality. However, it is not yet experimentally proved the influence of SF0.9% and SG5% on K+ replacement quality in patients with hypokalemia.Objectives: To assess the effects of different vehicles of K+ replacement on blood K+ levels in furosemide hypokalemic rats.Methods: Male Wistar rats were divided into four groups: K++SF, K++SG, SF and SG. Jugular vein was cannulated for K+ replacement and femoral vein was cannulated for blood analysis were performed. Furosemide (50mg/kg) was injected S.C. to induce hypokalemia. It was analyzed potassium plasmatic levels 24 hours before furosemide injection, 24 hours after furosemide injection and after 30 minutes post-replacement.Results: There was reduction in post-injection of K+ levels when compared to the basal values (pre-furosemide) in all groups. However, the levels [K+] returned to baseline in both groups receiving K++SF or K++SG, which was not observed in groups receiving only SF and SG. Only K+SF presented increased after K+ replacement (P< 0.05).Conclusion: K+ replacement diluted both in SF and SG did not affect blood K+ levels in rats. 368 PETENUSSO, M ET AL -Vehicle influence on potassium replacement effectiveness in hypokalemic rats Bras Cir Cardiovasc 2009; 24(3): 367-372 Descriptors Rev