The use of ultrafiltration for inflammatory mediators removal during cardiopulmonary bypass in coronary artery bypass graf surgery

Use of modified ultrafiltration in adults undergoing coronary artery bypass grafting is associated with inflammatory modulation and less postoperative blood loss: A randomized and controlled study

“…However, at 24 and 48 hours, the IL-6 levels were comparable between groups, as reported by others. 6,22,24 Although we observed an increase in TNFR2 expression in the MUF group, which may indicate a worsening of the inflammatory response, we did not observe any negative clinical outcome (ie, renal or cardiac dysfunction) related to this finding. Unfortunately, we cannot explain the biological importance of this observation.…”

“…By applying a similar filter as used in the present study, we previously showed that the efficient removal of inflammatory mediators from conventionally hemofiltered fluid had no clear clinical benefit when performed during CABG in adults. 22 Tallman and colleagues 23 found that use of zero-balance ultrafiltration in patients undergoing CABG had no clear clinical benefit, although it was capable of removing significant amounts of proinflammatory mediators (eg, IL-6, IL-1, and TNF). These findings are similar to those of the present study in terms of clinical variables, such as ICU and hospital lengths of stay.…”

Biochemical Measurement of Injury and Inflammation in Musculoskeletal Surgeries

“…Non-orthopedic studies have included a range of surgeries including: cardiac (Antunes et al, 2008;Booth et al, 2010), aortic (Baigrie), stomach (Aguilar-Nascimento et al, 2007;Herrera et al, 2010), bowel (Herroeder et al, 2007 ), liver (Gravante et al, 2010;Sato et al, 1996), hernias (Correla et al, 2001), cholesystemctomy (Chambrier et al, 1996;Kristiansson et al, 1999) and various cancers (Veenhof et al, 2011). Among orthopedic studies, there are now a large number of reports involving the use of biochemical injury measures for risk screening including their use in attempts to identify post-operative fever, and infection.…”

Lesão pulmonar e ventilação mecânica em cirurgia cardíaca: revisão

“…(1,8,17) Intraoperative inflammatory mediators filtration is not able to reduce inflammatory mediators levels, and also does not change the postoperative organ dysfunction rate in CBP grafted patients. (18) Cox et al…”