Características do transplante cardíaco neonatal e infantil

Barbero-Marcial, Miguel; Azeka, Estela; Camargo, Paula R.; Jatene, Marcelo Biscegli; Riso, Arlindo; Júnior, José Otávio Costa Auler; Soares, José; Monteiro, C.; Uip, Davi; Camargo, Laa; Santos, Sílvia Regina Cavani Jorge; Coelho, Verônica; Atik, Edmar; Ebaid, Munir; Jatene, Adib

doi:10.1590/s0102-76381996000200003

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…Cardiopulmonary bypass CSBC Congress of the Brazilian Society of Cardiology ANH Acute normovolemic hemodilution NYHA New York Heart Association rHuEPO recombinant human erythropoietin HLHS Hypoplastic Left Heart Syndrome cardiac transplantation has enabled survival and improved quality of life in children with severe myocardial dysfunction [8]. The graft failure occurs in approximately 7% of heart transplants in children [9] and in these cases, retransplantation becomes the only therapeutic option.…”

Section: Cpbmentioning

confidence: 99%

Heart retransplantation in children without the use of blood product

Santos¹,

Silva²,

Fonseca³

et al. 2012

Rev Bras Cir Cardiovasc

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This article reports a case of a cardiac retransplantation without the use of blood products, in a 6 year old child, with severe dilated cardiomyopathy after chronic graft rejection and refractory to clinical treatment. To avoid a blood transfusion in this surgery a multidisciplinary approach was planned, which involved the use of preoperative erythropoietin, acute normovolemic hemodilution and intraoperative cell savage with autologous blood recovery system, as well as a meticulous hemostasis and reduced postoperative phlebotomy. Resumo Este artigo relata um caso de retransplante cardíaco sem o uso de hemoderivados, em uma criança de 6 anos, com miocardiopatia dilatada grave, após rejeição crônica do enxerto e refratária ao tratamento clínico. Para evitar transfusão sanguínea nessa cirurgia, foi realizado planejamento multidisciplinar, que envolveu o uso de eritropoietina no pré-operatório, hemodiluição normovolêmica aguda e recuperação de sangue autólogo no intraoperatório (cell saver), bem como hemostasia meticulosa e redução de flebotomias no pós-operatório. Descritores: Transplante de coração. Criança. Eritropoetina. Transfusão de sangue autóloga. Rejeição de enxerto.

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Section: Cpbmentioning

confidence: 99%

Heart retransplantation in children without the use of blood product

Santos¹,

Silva²,

Fonseca³

et al. 2012

Rev Bras Cir Cardiovasc

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“…The patient was a newborn with left heart hypoplasia and a good outcome 11 years after the event 5 . Our first transplantation in a patient with left heart hypoplasia was performed in 1992 by Barbero-Marcial et al 6 .…”

Section: Original Articlementioning

confidence: 99%

Heart transplantation in neonates and children. Intermediate-term results

Azeka¹,

Barbero-Marcial²,

Jatene³

et al. 2000

Arq. Bras. Cardiol.

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“…In Brazil, the first HTx in a newborn was performed at our institution in November 1992 [ 3 ] . In April 2012, our team of Pediatric and Congenital Heart Surgery held its hundredth HTx, consolidating its position as the largest and most active center outside Europe and North America [ 4 ] .…”

Section: Introductionmentioning

confidence: 99%

“…We have several publications in this area, from 1996, when we published our initial experience [ 3 , 5 - 8 ] , to our two most recent studies, one addressing the results of HTx in patients with cardiogenic shock [ 9 ] and another in patients with rejection and cyclosporine intolerance [ 10 ] .…”

Section: Introductionmentioning

confidence: 99%

Pediatric and Congenital Heart Transplant: Twenty-year Experience in a Terciary Brazilian Hospital

Miana¹,

Azeka²,

Canêo³

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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IntroductionCardiac transplantation remains the gold standard for end-stage cardiomyopathies and congenital heart defects in pediatric patients.ObjectiveThis study aims to report on 20 years of experience since the first case and evaluate our results.MethodsWe conducted a retrospective analysis of the database and outpatient follow-up. Between October 1992 and April 2012, 109 patients underwent 114 transplants. 51.8% of them being female. The age of patients ranged from 12 days to 21 years with a mean of 8.8±5.7 years and a median of 5.2 years. The underlying diagnosis was dilated cardiomyopathy in 61.5%, congenital heart disease in 26.6% and restrictive cardiomyopathy in 11.9%. All patients above 17 years old had congenital heart disease.ResultsSurvival rate at 30 days, 1, 5, 10, 15, and 20 years were 90.4%, 81.3%, 70.9%, 60.5%, 44.4% and 26.7%, respectively. Mean cold ischemic time was 187.9 minutes and it did not correlate with mortality (P>0.05). Infectious complications and rejection episodes were the most common complications (P<0.0001), occurring, respectively, in 66% and 57.4% of the survivors after 10 years. There was no incidence of graft vascular disease and lymphoproliferative disease at year one, but they affected, respectively, 7.4% and 11% of patients within 10 years.ConclusionTwenty-year pediatric heart transplant results at our institution were quite satisfactory and complication rates were acceptable.

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Características do transplante cardíaco neonatal e infantil

Cited by 4 publications

References 4 publications

Heart retransplantation in children without the use of blood product

Heart retransplantation in children without the use of blood product

Heart transplantation in neonates and children. Intermediate-term results

Pediatric and Congenital Heart Transplant: Twenty-year Experience in a Terciary Brazilian Hospital

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