Heart transplantation in neonates and children. Intermediate-term results

Azeka, Estela; Barbero-Marcial, Miguel; Jatene, Marcelo B.; Camargo, Paulo M.; Júnior, José Otávio Costa Auler; Atik, Edmar; Ramires, José Antonio Franchini; Ebaid, Munir

doi:10.1590/s0066-782x2000000300002

Cited by 7 publications

(4 citation statements)

References 14 publications

(28 reference statements)

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“…5,6 In patients who do not respond to clinical treatment, heart transplantation remains the only therapeutic possibility. 7,8 It would be useful to have a marker of death to anticipate heart transplantation.…”

Section: Introductionmentioning

confidence: 99%

Is Myocardial Performance Index an Independent Echocardiographic Marker of Death in Children with Idiopathic Dilated Cardiomyopathy?

Azevedo¹,

Filho

Santos³

et al. 2008

Clin Cardiol

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Background: Myocardial performance index (MPI) was reported as a parameter of ventricular systolic and diastolic function, as well as a useful tool to predict the outcome in patients with ventricular dysfunction. Hypothesis: To compare MPI with classical echocardiographic parameters as an independent marker of death in children with idiopathic dilated cardiomyopathy (IDCM). Methods: Fifty-five children (13 deaths) underwent 104 echocardiograms from January 1996 to May 2005. Right ventricle (RV) MPI and left ventricle (LV) MPI, and 9 classical echocardiographic parameters (left atrium [LA]/body surface area [BSA], distance between mitral E point and ventricular septum, LV mass/body surface area, RV shortening fraction, LV end-systolic and end-diastolic dimensions/body surface area, LV ejection fraction, fiber circumferential shortening velocity, and mitral deceleration time) were compared. Statistical analysis was performed by chi-square, Pearson's correlation and Student t-test, Kaplan-Meier method, Cox's method, and receiver operating curve (ROC). Statistical significance was considered with α<0.05 and p = 0.80. Results: Univariate analysis showed that all studied parameters were markers of death. There was a high correlation between RVMPI and LVMPI (r = 0.847-p = 0.0001); therefore, to avoid bias, RVMPI was discharged from multivariate analysis. In the deceased group, moderate/severe mitral regurgitation was frequent (76.9%; confidence interval [CI] 95% = 46.2%-94.9%) and it was considered in multivariate analysis. In Cox's multivariate analysis, LVMPI was the only independent marker of death (p = 0.0213). The ideal cut-off was 0.63 with 92.3% sensitivity, 66.7% specificity, and fitted ROC area = 0.918. Conclusions: In children with IDCM, LVMPI is an independent marker of death.

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Section: Introductionmentioning

confidence: 99%

Is Myocardial Performance Index an Independent Echocardiographic Marker of Death in Children with Idiopathic Dilated Cardiomyopathy?

Azevedo¹,

Filho

Santos³

et al. 2008

Clin Cardiol

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“…In our study, the predominance of recipients transplanted due to cardiomyopathies is in line with data from developing countries, like ours. In the 2000s, in São Paulo, Azeka et al [ 9 ] reported that cardiomyopathies had been the indication for heart transplant in 97.3% of children over one year of age.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Heart Transplant: Initial Experience in a Tertiary Center in Brazil

Marchi

Beani

Godoy

et al. 2022

Braz J Cardiovasc Surg

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“…We have several publications in this area, from 1996, when we published our initial experience [ 3 , 5 - 8 ] , to our two most recent studies, one addressing the results of HTx in patients with cardiogenic shock [ 9 ] and another in patients with rejection and cyclosporine intolerance [ 10 ] .…”

Section: Introductionmentioning

confidence: 99%

Pediatric and Congenital Heart Transplant: Twenty-year Experience in a Terciary Brazilian Hospital

Miana

Azeka

Caneo

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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IntroductionCardiac transplantation remains the gold standard for end-stage cardiomyopathies and congenital heart defects in pediatric patients.ObjectiveThis study aims to report on 20 years of experience since the first case and evaluate our results.MethodsWe conducted a retrospective analysis of the database and outpatient follow-up. Between October 1992 and April 2012, 109 patients underwent 114 transplants. 51.8% of them being female. The age of patients ranged from 12 days to 21 years with a mean of 8.8±5.7 years and a median of 5.2 years. The underlying diagnosis was dilated cardiomyopathy in 61.5%, congenital heart disease in 26.6% and restrictive cardiomyopathy in 11.9%. All patients above 17 years old had congenital heart disease.ResultsSurvival rate at 30 days, 1, 5, 10, 15, and 20 years were 90.4%, 81.3%, 70.9%, 60.5%, 44.4% and 26.7%, respectively. Mean cold ischemic time was 187.9 minutes and it did not correlate with mortality (P>0.05). Infectious complications and rejection episodes were the most common complications (P<0.0001), occurring, respectively, in 66% and 57.4% of the survivors after 10 years. There was no incidence of graft vascular disease and lymphoproliferative disease at year one, but they affected, respectively, 7.4% and 11% of patients within 10 years.ConclusionTwenty-year pediatric heart transplant results at our institution were quite satisfactory and complication rates were acceptable.

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Heart transplantation in neonates and children. Intermediate-term results

Abstract: Objective -To assess intermediate-term outcome in children who have undergone orthotopic heart transplantation. Methods -

Cited by 7 publications

References 14 publications

Is Myocardial Performance Index an Independent Echocardiographic Marker of Death in Children with Idiopathic Dilated Cardiomyopathy?

Is Myocardial Performance Index an Independent Echocardiographic Marker of Death in Children with Idiopathic Dilated Cardiomyopathy?

Pediatric Heart Transplant: Initial Experience in a Tertiary Center in Brazil

Pediatric and Congenital Heart Transplant: Twenty-year Experience in a Terciary Brazilian Hospital

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