Topical anti-inflammatory activity of yacon leaf extracts

Oliveira, Rejane Barbosa de; Chagas‐Paula, Daniela Aparecida; Secatto, Adriana; Gasparoto, Thaís Helena; Faccioli, Lúcia Helena; Campanelli, Ana Paula; Costa, Fernando B. Da

doi:10.1590/s0102-695x2013005000032

Cited by 47 publications

(41 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[14] Yacon leaves also contain sesquiterpenelactones, which play a role in wound healing. Topical administration of yacon leaves extract reduced the inflammation by 44.1% compared to the control group [17].…”

Section: Macroscopic Evaluation Of Wound Healingmentioning

confidence: 88%

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

et al. 2018

View full text Add to dashboard Cite

Diabetic patient tend to suffer from lower extremity complication that contribute to the occurence of diabetic foot ulcer. Smallanthus sonchifolius or yacon leaves extract has been used as an alternative medicine for diabetes and also showed antibacterial activity. This research aims to obtain the antihyperglycemic and diabetic wound healing activity of yacon leaves extract. Diabetic condition of rat was induced by streptozotocin (45 mg/kg bw) and nicotinamide (110 mg/kg bw). Rats were then allowed to develop diabetes for 21 days. A biopsy punch then was used to create a wound. Yacon leaves extract were administered by oral and topical for 14 day. The serum glucose level and diameter of the wound were measured every week, and histopatology study of the skin was conducted at the end of the study. Oral administration of yacon leaves extract (150 mg/kg bw) together with topical administration showed antihyperglycemic as well as diabetic wound healing activities comparable to the reference drugs (glibenclamide oral and nebacetin cream).

show abstract

Section: Macroscopic Evaluation Of Wound Healingmentioning

confidence: 88%

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

et al. 2018

View full text Add to dashboard Cite

show abstract

“…[6][7][8] Because of these many positive influences on human body, since the middle of the 19 th century, when the first references about CGAs appeared, there have been a high amount of articles dealing with extraction and detection techniques of CGAs or studying their influence on human health. CGAs have been observed and isolated in many plant materials such as coffee 9 , apple 10 , tomato, papaya 11 , sweet potato 12 , prune 13 , pear 14 , cabbage 15 , yacon 16 , burdock 17 , cherry 18 , apricot 19 , orange 20 , etc. Coffee beans are undoubtedly the most common observed matrix because coffee is the main source of CGAs.…”

Section: Introductionmentioning

confidence: 99%

Unremitting Problems With Chlorogenic Acid Nomenclature: A Review

Kremr¹,

Bajer²,

Bajerová³

et al. 2016

Química Nova

View full text Add to dashboard Cite

Recebido em 08/12/2015; aceito em 12/01/2016; publicado na web em 12/04/2016 This paper summarizes a problematic nomenclature of isomers belonging to chlorogenic acid family since its first occurrence until present. During decades, there have been a high number of articles dealing with the family. Unfortunately, researchers who want to get knowledge about this topic may be strongly confused after reading a few articles. Due to gradual discoveries and isolations of the individual isomers from plenty of matrices and because of the changing system of terminology after these discoveries, discrepancies among articles are common. The cause of this confusion is that the main compound of the family, 5-caffeoylquinic acid (also wellknown as chlorogenic acid), was truly called as 3-caffeoylquinic acid before 1976, when new rules for nomenclature were published. Many researchers and also chemicals suppliers, however, keep using the "pre-IUPAC" nomenclature and wrongly call 3-caffeoylquinic acid as chlorogenic acid, the main substituent of the family. Despite there have been some works struggling with this issue, the problem is still appearing. Therefore, the present work was written.

show abstract

“…19 Plants such as C. ternatea L. (Leguminosae) Smallanthus sonchifolius oleoresins such as capsicum and thyme, icariside E4from U. Pumila also possess anti-inflammatory effect. [20][21][22][23][24] The ROS-generating enzymes such as iNOS, cyclooxygenase and lipoxygenase can be inhibited by flavonoids and thus can inhibit their pro-inflammatory activity. The plant, M. longifolia has a good antiinflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Effect of the Aqueous Fruit Pulp Extract of Tamarindus indica Linn in Lipopolysaccharide-Stimulated Macrophages

Leya¹,

Anitha²

2019

View full text Add to dashboard Cite

The aim of the present study was to evaluate the effect of the aqueous fruit pulp extract of Tamarind indica Linn on NO production and iNOS expression in LPS stimulated RAW 264.7 macrophages. Material and Method: The efficacy of tamarind extract on nitric oxide production was determined using RAW macrophages. RT-PCR was used to examine the expression of the iNOS gene in activated macrophages. The Statistical analysis for multiple comparisons was evaluated by one way ANOVA followed by the Dunnett's test when significant differences were detected. The data were considered to be statistically significant at p < 0.001, p < 0.01 and p < 0.05. Results: LPS stimulated RAW macrophages strongly up regulated the iNOS gene expression levels. The iNOS levels were significantly suppressed in the presence of different concentrations of tamarind extract, compared to LPS treatment alone. The tamarind extract also exhibited dose-dependent decrease in the production of NO. The IC 50 was found to be 35.69 µg/ml. LPS stimulated group showed 89.61 ± 0.47 % of NO. Conclusion: Nitric oxide production is found to be more in conditions such as periodontitis, oral squamous cell carcinoma and many other diseases. This study could prove the ability of tamarind fruit pulp extract to inhibit the production of nitric oxide and the iNOS gene expression. Hence, Tamarind indica Linn pulp extract may be used as a good anti-inflammatory agent in periodontitis as well as in conditions associated with over production of nitric oxide in different cancers such as oral squamous cell carcinoma.

show abstract

Topical anti-inflammatory activity of yacon leaf extracts

Cited by 47 publications

References 27 publications

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

Unremitting Problems With Chlorogenic Acid Nomenclature: A Review

Anti-inflammatory Effect of the Aqueous Fruit Pulp Extract of Tamarindus indica Linn in Lipopolysaccharide-Stimulated Macrophages

Contact Info

Product

Resources

About