Argemone mexicana: Chemical and pharmacological aspects

Brahmachari, Goutam; Gorai, Dilip; Roy, Rustum

doi:10.1590/s0102-695x2013005000021

Cited by 102 publications

(60 citation statements)

References 53 publications

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“…Swertia species, which belong to the family Gentianaceae, are widely used in traditional medicine in many Asian countries such as China, India and Japan. Pharmacological research indicated that the plants of the Swertia genus have a variety of biological effects, including hepatoprotective, antidiabetic, antiinflammatory, anticholinesterase, antioxidant and antimicrobial (Brahmachari et al, 2004). Swertianolin, a xanthone glucoside isolated from the Swertia species, is one of the representative constituents of many Swertia species, such as S. chirayita, S. mussotii, S. japonica and S. punctata (Sakamoto et al, 1982;Li et al, 2008;Singh et al, 2012;Menkovic et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Swertianolin, a xanthone glucoside isolated from the Swertia species, is one of the representative constituents of many Swertia species, such as S. chirayita, S. mussotii, S. japonica and S. punctata (Sakamoto et al, 1982;Li et al, 2008;Singh et al, 2012;Menkovic et al, 2002). Swertianolin has been reported to possess hepatoprotective, anticholinesterase, antituberculosis, antioxidant, antiarrhythmic and antidiabetic effects (Brahmachari et al, 2004;Li et al, 2005;Urbain et al, 2004Urbain et al, , 2008Mukherjee et al, 2007;Wani et al, 2013;Wan et al, 2013). Despite its various biological activities, the pharmacokinetic properties of swertianolin have not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Determination of swertianolin in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study

Tian

Ouyang

et al. 2014

Biomedical Chromatography

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A sensitive and rapid LC-MS/MS method has been developed and validated for quantifying swertianolin in rat plasma using rutin as an internal standard (IS). Following liquid-liquid extraction with ethyl acetate, chromatographic separation for swertianolin was achieved on a C18 column with a gradient elution using 0.1% formic acid as mobile phase A and acetonitrile as mobile phase B at a flow rate of 0.3 mL/min. The detection was performed on a tandem mass spectrometer using multiple reaction monitoring via an electrospray ionization source and operating in the negative ionization mode. The optimized mass transition ion pairs (m/z) for quantitation were 435.1/272.0 for swertianolin and 609.2/300.1 for IS. The lower limit of quantitation was 0.5 ng/mL within a linear range of 0.5-500 ng/mL. Intra-day and inter-day precision was less than 6.8%. The accuracy was in the range of -13.9 to 12.0%. The mean recovery of swertianolin was >66.7%. The proposed method was successfully applied in evaluating the pharmacokinetics of swertianolin after an oral dose of 50 mg/kg Swertia mussotii extract in rats.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of swertianolin in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study

Tian

Ouyang

et al. 2014

Biomedical Chromatography

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“…Methanolic extract of Argemone mexicana's leaves exhibit cytotoxic activities IC 50 (1.82 μg/mL) and IC 50 (1.35 μg/mL) against MDA-MB-435S and MCF-7 respectively by using MTT assay. Alkaloids isolated from its extract may be responsible for inhibitory activities (Brahmachari et al, 2013: Gali et al, 2011. Similarly, methanolic extract of Arisaema flavum showed maximum inhibition (83%) at 500 mg/mL against MCF-7, while aqueous extract showed minimum inhibition (1.2%).…”

Section: Breast Cancermentioning

confidence: 99%

“…A single dose (10 mg/kg) of sanguinarine tested in swiss albino mice have resulted in considerable loss of body weight, peritoneal edema and slightly enlarged livers with fibrinous material (Brahmachari et al, 2013). In another experiment, Bergenia ciliata showed acute systematic and intra cutaneous toxicities in experimental animals, which caused breathing problems, initiation of diarrhea with blood in stool and gastrointestinal syndrome (Ruby et al, 2012).…”

Section: Toxicologymentioning

confidence: 99%

Review on ethnomedicinal, phytochemical and pharmacological evidence of Himalayan anticancer plants

Tariq

Mussarat

Adnan

2015

Journal of Ethnopharmacology

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“…A drink prepared from the roasted and boiled leaves is given to children as a vermifuge. 18 It has been used traditionally to prepare herbal medicines and traditional teas, while a limited number of reports concerning the chemical constituents and biological activities of Microcos paniculata have appeared in the literature . But no valid reports are available about the effects of ethanolic extracts of Baccaurea ramiflora and Microcos paniculata against alcohol and paracetamol induced hepatic damage.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Ethanolic Extract of Baccaurea Ramiflora and Microcos Paniculata Against Alcohol and Paracetamol Induced Hepatotoxicity in Albino Rats

Saha¹,

Gouda²,

Srinivas³

2017

Int. Res. J. Pharm.

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Ayurveda an ancient Indian system of medicine claims to have remedy for disorders like jaundice and liver cirrhosis, which is inadequate with present allopathy. The present study was conducted to find out the hepatoprotective activity of ethanolic extracts of Baccaurea ramiflora and Microcos paniculata against alcohol and paracetamol induced liver damage in rats. Hepatotoxicity was induced by alcohol and paracetamol and the biochemical parameters such as serum glutamic oxaloacetic transaminase (sGOT), serum glutamic pyruvic transaminase (sGPT), and serum alkaline phosphatase (sALP), serum bilirubin (SB) and histopathological changes in liver were studied along with silymarin as standard hepatoprotective agents. The phytochemical investigation of the extracts showed presence of alkaloids, glycosides, tannins, saponins, proteins and flavonoids. Ethyl alcohol (1.5ml/kg) and Paracetamol (750mg/kg) has enhanced the SGPT, SGOT, ALP and billirubin level reduced. Treatment with ethanolic extracts of Baccaurea ramiflora and Microcos paniculata leaves (100mg/kg and 200mg/kg) has brought back the altered level of biochemical markers to the near normal levels almost comparable to the silymarin. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals. From the results it can be concluded that Baccaurea ramiflora and Microcos paniculata possesses hepatoprotective effect against alcohol and paracetamol-induced liver damage in rats.

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Argemone mexicana: Chemical and pharmacological aspects

Cited by 102 publications

References 53 publications

Determination of swertianolin in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study

Determination of swertianolin in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study

Review on ethnomedicinal, phytochemical and pharmacological evidence of Himalayan anticancer plants

Hepatoprotective Activity of Ethanolic Extract of Baccaurea Ramiflora and Microcos Paniculata Against Alcohol and Paracetamol Induced Hepatotoxicity in Albino Rats

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