Herbal medicines: Old and new concepts, truths and misunderstandings

Carmona, Fábio; Pereira, Ana Maria Soares

doi:10.1590/s0102-695x2013005000018

Cited by 115 publications

(90 citation statements)

References 24 publications

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“…7,18,19 Given the challenges of developing appropriate CAM research methods for whole plants, 20 let alone whole systems, the question remains as to what is the best evidence currently available for the efficacy of TM/CAM therapies to inform decision making in CAM clinical practice? Hence, there is a fundamental mismatch between the two.…”

Section: Complexity and Controlmentioning

confidence: 99%

“…Even within biomedicine the gold standard of RCT is increasingly being seen to lack effectiveness when applied to systems of health care. 7,18,19 Given the challenges of developing appropriate CAM research methods for whole plants, 20 let alone whole systems, the question remains as to what is the best evidence currently available for the efficacy of TM/CAM therapies to inform decision making in CAM clinical practice? The debate on traditional-medicine treatments, their safety and efficacy, sham medicines, how to test and what to test, has raged on for well over 20 years.…”

Section: Complexity and Controlmentioning

confidence: 99%

See 1 more Smart Citation

Does ‘traditional’ evidence have a place in contemporary complementary and alternative medicine practice? A case for the value of such evidence

Wiese

2016

Focus on Alt & Comp Therapy

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Section: Complexity and Controlmentioning

confidence: 99%

Section: Complexity and Controlmentioning

confidence: 99%

Does ‘traditional’ evidence have a place in contemporary complementary and alternative medicine practice? A case for the value of such evidence

Wiese

2016

Focus on Alt & Comp Therapy

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“…In many developed countries, about 70 -80% of the population use CAM [9]. In spite of this, phytotherapeutics, or the use of herbs for medicines has not been accepted into mainstream healthcare delivery, probably due to lack of knowledge by orthodox practitioner [10].…”

Section: Introductionmentioning

confidence: 99%

Anti-arthritic Activity of a Herbal Formulation (Jointeez) in Albino Wistar Rats

Elechi-Amadi

Nwachuku

Tamuno-Emine

et al. 2019

JOCAMR

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Aim: This study evaluated the anti-arthritic activity of a herbal formulation used in the management of rheumatoid arthritis in Nigeria. Design: Thirty-five (35) albino wistar rats were used. They were divided into seven groups of seven rats each, with Group A serving as negative control while Group B was the positive control. Groups B, C, D and E were induced with rheumatoid arthritis by injecting 0.1 ml of Complete Freund’s Adjuvant into the right hind paw of each rat. The rats were treated with the standard drug and herbal formulation respectively for 28 days as follows: Group C (treated with a standard drug, Celebrex), Group D (treated with the herbal drug, Jointeez), Group E (treated with a combination therapy of Jointeez and Celebrex). At the end of the 28-day treatment period, the rats were anaesthesized with chloroform and sacrificed through puncture of the jugular vein. Five millilitres (5 ml) of blood samples were put into plain bottles for the analysis of biochemical parameters. Place and Duration of Study: This study was conducted in the Department of Medical Laboratory Science, Rivers State University, from September to December, 2018. Methodology: The inflammatory markers, tumour necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and C-reactive protein, were analysed using ELISA technique. Results: The levels of TNF-α (p<0.001), IL-6 (p =0.01) and C-reactive protein (p <0.001) were significantly reduced in the treated rats compared to the positive control group. There were significant reduction in the paw diameters of the treated rats (p <0.001). The combination therapy used in this study did not offer significantly different therapeutic advantage over the monotherapies used in this study. The herbal formulation used in this study offered similar therapeutic activities as the orthodox drug used in this study. Conclusion: The herbal formulations can be used as safe therapies for the management of rheumatoid arthritis in our population. It is recommended that herbal formulations be integrated into our healthcare system in the management of rheumatoid arthritis.

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“…The efficacy of phytotherapeutics often results from a complex composition of substances [1,2]. The complexity of plant-based drugs is one reason for the lack of satisfactory studies into their effect and causes problems for the definition and assurance of quality [3].…”

Section: Introductionmentioning

confidence: 99%

Quality-by-Design (QbD) process evaluation for phytopharmaceuticals on the example of 10-deacetylbaccatin III from yew

Uhlenbrock

Sixt

Strube

2017

Resource-Efficient Technologies

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The focus of pharmaceutical product development lies on assuring excellent product quality at the end of a cost-efficient process. The Quality-by-Design (QbD) concept shifts the focus from quality assurance through testing to quality control by process understanding, resulting in very robust processes with high quality product. QbD was originally intended by authorities for biologics, where product quality proven completely by analytics is not desired. Product quality has to be controlled by means of appropriate processes and operations as well.These demands were developed in order to improve patients' safety by optimal drug quality at more efficient manufacturing processes reducing costs for healthcare systems. Furthermore, production of biologics includes feedstock variability and complex multi-step manufacturing processes in batch operation with variable lots -condition, which apply to botanicals as well.The use of rigorous (physico-chemical) process modeling in combination with QbD results in a high degree of process understanding. This offers, contrary to popular prejudices, great benefit for manufacturers with little extra effort during development.The methodical QbD-based approach is pursued to develop a process for extraction and purification of 10-deacetylbaccatin III from yew needles. A short history and key elements of the QbD-based application are introduced.The line of argument for basic process conception is described and initial risk assessment is shown. Typical raw material variation and vaporization are identified as causes of process variability, therefore, the implications to subsequent process steps are pointed out. Finally, influences of load and flow rate on the chromatographic separation of 10-deacetylbaccatin III are shown to exemplify sensitivity of purification design.

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Herbal medicines: Old and new concepts, truths and misunderstandings

Cited by 115 publications

References 24 publications

Does ‘traditional’ evidence have a place in contemporary complementary and alternative medicine practice? A case for the value of such evidence

Does ‘traditional’ evidence have a place in contemporary complementary and alternative medicine practice? A case for the value of such evidence

Anti-arthritic Activity of a Herbal Formulation (Jointeez) in Albino Wistar Rats

Quality-by-Design (QbD) process evaluation for phytopharmaceuticals on the example of 10-deacetylbaccatin III from yew

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