Chrysobalanaceae: traditional uses, phytochemistry and pharmacology

Feitosa, Evanilson Alves; Xavier, Haroudo Sátiro; Randau, Karina Perrelli

doi:10.1590/s0102-695x2012005000080

Cited by 31 publications

(24 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genus Licania (Chrysobalanaceae) consists of more than 200 species of trees and shrubs, which are mainly distributed in tropical regions of America and Africa [1,2]. The species of the genus Licania have been used in South America for various medicinal purposes such as the treatment of inflammation [3], diabetes [4], stomach ache, diarrhea, and dysentery [5]. Previous phytochemical studies of this genus have reported the isolation of two main classes of compounds: flavonoid glycosides based on myricetin and quercetin moieties and triterpenes of the lupane, oleane or ursane types [4].…”

Section: Introductionmentioning

confidence: 99%

“…The species of the genus Licania have been used in South America for various medicinal purposes such as the treatment of inflammation [3], diabetes [4], stomach ache, diarrhea, and dysentery [5]. Previous phytochemical studies of this genus have reported the isolation of two main classes of compounds: flavonoid glycosides based on myricetin and quercetin moieties and triterpenes of the lupane, oleane or ursane types [4]. In the present work, we report the isolation from the leaves of Licania cruegeriana Urb.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects

et al. 2014

View full text Add to dashboard Cite

Three new lupane-type triterpenoids: 6β,30-dihydroxybetulinic acid glucopyranosyl ester (4), 6β,30-dihydroxybetulinic acid (5) and 6β-hydroxybetulinic acid (6), were isolated from Licania cruegeriana Urb. along with six known compounds. Their structures were elucidated on the basis of spectroscopic methods, including IR, ESIMS, 1D-and 2D-NMR experiments, as well as by comparison of their spectral data with those of related compounds. All compounds were evaluated in vivo for their effects on the mean arterial blood pressure (MABP) and heart rate (HR) of spontaneously hypertensive rats (SHR) and also in vitro for their capacity to inhibit the human platelet aggregation. None of the isolated flavonoids 1-3 showed cardiovascular effects on SHR and among the isolated triterpenoids 4-9 only 5 and 6 produced a significant reduction in MABP (60.1% and 17.2%, respectively) and an elevation in HR (11.0% and 41.2%, respectively). Compounds 3, 4, 5 and 6 were able to inhibit human platelet aggregation induced by ADP, collagen and arachidonic acid with different selectivity profiles.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Flavonoids and terpenes are the major compounds present in Chrysobalanaceae species. [ 24 ] Using aluminum complexation reaction, the determination of TFC in HECi showed high level, which highlights the majority of these compounds present in C. icaco . Among the flavonoids previously reported for C. icaco , myricetin[ 8 ] figure as its possible phytochemical marker.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of hydroalcoholic extract of Chrysobalanus icaco against oral clinical isolates of Candida Species

et al. 2017

View full text Add to dashboard Cite

Background:Chrysobalanus icaco is a medicinal plant commonly used to treat fungal infections in Brazilian Amazonian region.Objective:This work aimed to evaluate the antifungal activity of the hydroalcoholic extract of C. icaco (HECi) against oral clinical isolates of Candida spp. and to determine the pharmacognostic parameters of the herbal drug and the phytochemical characteristics of HECi.Materials and Methods:The pharmacognostic characterization was performed using pharmacopoeial techniques. Phytochemical screening, total flavonoid content, and high-performance liquid chromatography (HPLC) analysis were used to investigate the chemical composition of the HECi. A broth microdilution method was used to determine the antifungal activity of the extract against 11 oral clinical isolates of Candida spp.Results:Herbal drug presented parameters which were within the limits set forth in current Brazilian legislation. A high amount of flavonoid content (132,959.33 ± 12,598.23 μg quercetin equivalent/g of extract) was found in HECi. Flavonoids such as myricetin and rutin were detected in the extract by HPLC analyses. HECi showed antifungal activity against oral isolates of Candida albicans and Candida parapsilosis (minimum inhibitory concentrations [MIC] 3.12 and 6.25 mg/mL, respectively), and C. albicans American American Type Culture Collection (MIC <1.56 mg/mL).Conclusion:HECi was shown to possess antifungal activity against Candida species with clinical importance in the development of oral candidiasis, and these activities may be related to its chemical composition. The antifungal activity detected for C. icaco against Candida species with clinical importance in the development of oral candidiasis can be attributed to the presence of flavonoids in HECi, characterized by chromatographic and spectroscopic techniques.SUMMARY Chrysobalanus icaco presents a high amount of flavonoids in its constitutionLC analysis was able to identify the flavonoids myricetin and rutin in C. icaco hydroalcoholic extractThe C. icaco hydroalcoholic extract inhibits the growth of oral clinical isolates of Candida spp. and Candida albicans American Type Culture Collection. Abbreviations Used: HECi: Hydroalcoholic extract of C. icaco; HPLC: High performance liquid chromatography; AlCl3: Aluminum chloride; DMSO: Dimethyl sulfoxide; CH3NOONa: Sodium acetate; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ATCC: American Type Culture Collection; EMBRAPA: Brazilian Agricultural Research Corporation – Eastern Amazon; v/v: Volume per volume; SD: Standard deviation; TFC: Total flavonoid content; w/v: Weight per volume; ELSD: Evaporative light scattering detector; DAD: Diode-arrange detector; UFPA: Federal University of Pará; IEC: Evandro Chagas Institute; INCQS-FIOCRUZ: National Institute of Quality Control in Health – Fundação Oswaldo Cruz; SDA: Sabouraud Dextrose Agar; CFU: Colony-forming units; MIC: Minimum inhibitory concentrations; MFC: Minimum fungicidal concentrations

show abstract

“…It is popularly called ataiko and is known for its ability to enhance taste and food aroma and improve several alcoholic and non-alcoholic beverages among Urhobos and Uk-wuanis of Delta State Nigeria [12,13]. It has been widely researched and reported to be rich in phytochemicals and possess several ethnopharmocological properties; thus, it is reported for its efficacy in the traditional herbal management of malaria [14], wound healing, management of postnatal malignancies after delivery [15] and the treatment of several models of diabetes mellitus [16,17]. The efficacy of A. sceptrum extracts has been explored in the preservation of food products like meat and the oxidative deterioration of palm oil [18,19].…”

Section: Problem Statement and Analysis Of The Latest Researchmentioning

confidence: 99%

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

2019

View full text Add to dashboard Cite

The objective of the research was to explain the possible mechanism of an earlier reported role of Aframomum sceptrum extract in the modulation of renal function parameters in monosodium glutamate-induced toxicity. Materials and Methods. Similar experimental methods previously reported by us in Ogbeke et al., (2016) were maintained. Results. Monosodium glutamate administration led to a significant elevation of levels of serum and kidney lipid peroxidation due to decrease in the levels of serum and kidney antioxidant enzyme, super oxide dismutase, catalase, gluthathione peroxidase and gluthathione. There was observed increase in oxidative enzyme, aldehyde oxidase, sulphite oxidase, xanthine oxidase and monoamine oxidase activities in serum and kidney after monosodium glutamate consumption. Aframomum sceptrum treatment significantly regulated all altered indices. Conclusions. The study concluded that the ability of Aframomum sceptrum extract to modulate renal function parameters in monosodium glutamate-induced toxicity is dependent on its efficacy in the induction and mobilization of antioxidant defense armory via the increased synthesis of tissue and serum enzymatic and non-enzymatic antioxidants, as well as improved oxidative enzyme activities that mediates the quenching of rising aldehydes and sulfoxides, N-oxides and aromatic oxides within the kidney.

show abstract

Chrysobalanaceae: traditional uses, phytochemistry and pharmacology

Cited by 31 publications

References 53 publications

Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects

Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects

Antifungal activity of hydroalcoholic extract of Chrysobalanus icaco against oral clinical isolates of Candida Species

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

Contact Info

Product

Resources

About