Anti-HSV activity of Hypnea musciformis cultured with different phytohormones

Mendes, Gabriella S.; Bravin, Isolda Cecília; Yoneshigue‐Valentin, Yocie; Yokoya, Nair S.; Romanos, Maria Teresa Villela

doi:10.1590/s0102-695x2012005000054

Cited by 14 publications

(8 citation statements)

References 32 publications

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“…Anti-HSV-1 activity of sulphated galectins from the Rhodophyta Pterocladia capillacea was already investigated by Pujol et al [145], and these compounds showed antiviral activity with an EC 50 value ranging from 3.2 to 6.1 µg/mL −1 . Anti-HSV-1 activity of hot water extract of Hypnea musciformis has also been confirmed in previous pre-clinical studies [146,150], where it expresses the highest inhibitory effect on HSV-1 with Asparagopsis armata, Corallium rubrum, Gelidum spinulosum, Plocamium cartilagineum and Sphaerococcus coronopifolius.…”

Section: Anti-herpetic Activity Of Seaweedssupporting

confidence: 72%

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Lomartire

Gonçalves

2022

Marine Drugs

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In the last decades, the interest in seaweed has significantly increased. Bioactive compounds from seaweed’s currently receive major attention from pharmaceutical companies as they express several interesting biological activities which are beneficial for humans. The structural diversity of seaweed metabolites provides diverse biological activities which are expressed through diverse mechanisms of actions. This review mainly focuses on the antiviral activity of seaweed’s extracts, highlighting the mechanisms of actions of some seaweed molecules against infection caused by different types of enveloped viruses: influenza, Lentivirus (HIV-1), Herpes viruses, and coronaviruses. Seaweed metabolites with antiviral properties can act trough different pathways by increasing the host’s defense system or through targeting and blocking virus replication before it enters host cells. Several studies have already established the large antiviral spectrum of seaweed’s bioactive compounds. Throughout this review, antiviral mechanisms and medical applications of seaweed’s bioactive compounds are analyzed, suggesting seaweed’s potential source of antiviral compounds for the formulation of novel and natural antiviral drugs.

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Section: Anti-herpetic Activity Of Seaweedssupporting

confidence: 72%

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Lomartire

Gonçalves

2022

Marine Drugs

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“…These variants and clavanin MO were tested against the Aichi virus and showed a range of inhibition of 0 to 41%. Molecules that presented a PI lower than 70% were not considered effective candidates for the development of new pharmaceuticals and for this reason were here excluded.…”

Section: Discussionmentioning

confidence: 99%

Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus

et al. 2017

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Viruses are the major cause of disease and mortality worldwide. Nowadays there are treatments based on antivirals or prophylaxis with vaccines. However, the rising number of reports of viral resistance to current antivirals and the emergence of new types of virus has concerned the scientific community. In this scenario, the search for alternative treatments has led scientists to the discovery of antimicrobial peptides (AMPs) derived from many different sources. Since some of them have shown antiviral activities, here we challenged 10 synthetic peptides from different animal and plant sources against, herpes simplex virus 1 (HSV-1), and Aichi virus. Among them, the highlight was Pa-MAP from the polar fish Pleuronectes americanus, which caused around 90% of inhibition of the HSV with a selectivity index of 5 and a virucidal mechanism of action. Moreover, LL-37 from human neutrophils showed 96% of inhibition against the Aichi virus, showing a selectivity index of 3.4. The other evaluated peptides did not show significant antiviral activity. In conclusion, the present study demonstrated that Pa-MAP seems to be a reliable candidate for a possible alternative drug to treat HSV-1 infections. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 108: 1-6, 2017.

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“…In addition, seaweeds are associated with antioxidant, antiviral, antibacterial, anthelmintic and antifungal activities as well as cytotoxicity, suggesting many potential applications in the pharmaceutical, nutraceutical and agricultural fields …”

Section: Introductionmentioning

confidence: 99%

Chemical analysis and toxicity of seaweed extracts with inhibitory activity against tropical fruit anthracnose fungi

Machado

Matsumoto

Jamal

et al. 2013

J. Sci. Food Agric.

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Anti-HSV activity of Hypnea musciformis cultured with different phytohormones

Cited by 14 publications

References 32 publications

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus

Chemical analysis and toxicity of seaweed extracts with inhibitory activity against tropical fruit anthracnose fungi

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