Protective effect of Habenaria intermedia tubers against acute and chronic physical and psychological stress paradigms in rats

Habbu, PV; Smita, DM; Mahadevan, Kittappa M.; Shastry, RA; Biradar, SM

doi:10.1590/s0102-695x2012005000033

Cited by 17 publications

(11 citation statements)

References 31 publications

(33 reference statements)

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“…(Orchidacea) (Habbu et al. 2012 ) provide immunoprotection under stressful conditions in mice and rats. Hence, immunostimulatory plants are likely candidates to maintain a disease-free state and can be helpful in therapy.…”

Section: Introductionmentioning

confidence: 99%

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The protective effect of the Vacha rhizome extract on chronic stress-induced immunodeficiency in rat

Sarjan

Divyashree

Yajurvedi

2017

Pharmaceutical Biology

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Context: Chronic stress is an inevitable factor in the modern day society which affects cell mediated as well as humoral immunity. There is a need to prevent stress effects with traditionally used herbs.Objective: The present study was undertaken to investigate the immunoprotective effect of Vacha (Acorus calamus L. Acoraceae) rhizome under stressful condition.Materials and methods: Soxlet extraction of Vacha rhizome was performed with increasing polarity of solvents, i.e., petroleum ether to ethanol. The extract was concentrated by distilling off the solvent in flash evaporator and dried in desiccators. The benzene extract was found to have anti-stress property in our earlier studies and hence it was used in the present experiment. Extract was administered every day for 4 weeks orally to adult female rats prior to exposure to stress, restraint (1 h) and forced swimming exercise (15 min).Results: Vacha rhizome extract significantly prevented the stress induced reduction in total and differential leukocytes count, immunoglobulin content, bone marrow cellularity and viability, lymphocytes counts in lymphoid organs, islands of white pulp of spleen (ED50 = 10 mg, p < 0.001) and a significant increase in circulating immune complexes and apoptotic index of lymphoid organs (ED50 = 10 mg, p < 0.001) compared to controls.Discussion and conclusion: The present study clearly indicates that Vacha extract not only prevents stress-induced suppression of immunity and structural involution of lymphoid organs, but also boosts immunity in normal rats. Therefore, it is suggested that Vacha extract administration maintains normal immunity despite the body experiencing stress.

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Section: Introductionmentioning

confidence: 99%

“…The herbal extracts investigated for immunoprotection (Bhattacharyaa & Muruganandam 2003 ; Juvekar & Nachankar 2005 ; Habbu et al. 2012 ) under stressful conditions mainly focused on blood leukocytes and phagocytosis. However, studies involving different parameters viz.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of the Vacha rhizome extract on chronic stress-induced immunodeficiency in rat

Sarjan

Divyashree

Yajurvedi

2017

Pharmaceutical Biology

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“…The mass spectral data of the compound showed molecular ion peak at m/z 192.0418 [M+H] + , corresponding to the molecular formula C 10 H 8 O 4 which was supported by the 13 C NMR spectral data. The IR spectrum showed absorption at 3350 cm -1 (OH); 1670 cm -1 (OH); 1670 cm -1 (CO); 1615 cm -1 (C=C); 1564 cm -1 and 1449 cm -1 (aromatic C-C) [7]. 1 H NMR spectra (Table 1) of the compound showed the presence of four aromatic protons (δ H 6.22, 6.77, 7.86, and 7.18 ppm) also one methoxy group appeared at δ H 3.92.…”

Section: Resultsmentioning

confidence: 99%

Constituents from the Stems of Malaysian Uncaria tomentosa

Wahid¹,

Noor²,

Khamis³

et al. 2014

TOPROCJ

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Uncaria tomentosa (Willd. ex Schult.) DC. is well known as a medicinal plant that has been used for various treatments. This tropical vine grows up to 30 m tall and commonly found in natural forest. It has hook-like thorns that resemble the claws of a cat. The leaves are elliptic with a smooth edge, and grow in opposite whorls of two. Although there has not been any literature found on the availability of this species locally, we have discovered it in several parts of Peninsular Malaysia. A preliminary investigation of the stems of the plant has yielded three compounds, scopoletin, isopteropodine along with ß-sitosterol. The structures of the isolated compounds were characterized by analysis of spectral characteristics (mostly 1D, 2D NMR and mass spectrometry) and comparison with literature.

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“…Presence of various phenolic compounds, such as catechin (1), gallic acid (2), ρ-coumaric acid (3), hydroxybenzoic acid (6), and scopoletin (7) supports them as the promising source of antioxidants [210][211][212][213]. In various fractions of H. intermedia, adaptogenic activity was also studied using immobilization induced acute stress (AS), chronic stress (CS) and swimming induced stress in experimental animals, which proved it as anti-stress agent [210].…”

Section: Habenaria Intermediamentioning

confidence: 99%

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Misra¹

2018

JONAM

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Astavarga is nature's most extravagant group of flowering plants found in Himalayan region. As the name Astavarga indicates, it contains eight medicinal plants belonging to Zingiberaceae, Orchidaceae and Liliaceae family viz, Kakoli, Kshirakakoli, Meda, Mahameda, Jeevak, Risbhaka, Riddhi and Vridddhi. As per Ayurveda this group of medicinal plants is classified as Rasayana (Rejuvenation) and is important constituents of preparations like Chyawanprasha rasayan, Ashtavarga churna, Brimhanigutika and Vajikaraghrita, etc. Astavarga plants are mostly used to treat sexual disorders, physical weakness, body pain, strengthen the immune system and as an overall tonic. The plants under this group have been the subject of limited biochemical phytochemical and biological activities investigations. Taking into consideration the therapeutic significance of Astavarga plants as described in the ancient Ayurvedic system of medicine, the detailed phytochemical and pharmacological studies appear imperative to scientifically validate the ancient claims. Thus, the present review article provides detailed information on the Ayurvedic uses, habit and habitats, botanical descriptions, chemical constituents and biological activities reported for this important group of plants. The chemical structures of the isolated compounds from these plants and their reported biological activities in the literature have also been included.The information provided in the present review may stimulate the researchers to explore their phytochemical and pharmacological properties which have not yet been attempted, comprehensively. It will generate the interest on "reverse pharmacology" approach to validate the knowledge that has been known from ancient times.

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Protective effect of Habenaria intermedia tubers against acute and chronic physical and psychological stress paradigms in rats

Cited by 17 publications

References 31 publications

The protective effect of the Vacha rhizome extract on chronic stress-induced immunodeficiency in rat

The protective effect of the Vacha rhizome extract on chronic stress-induced immunodeficiency in rat

Constituents from the Stems of Malaysian Uncaria tomentosa

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

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