Anti-tumor activity of the methanolic extracts of Salvia menthifolia

Abstract

Abstract:In the present research we investigated the anti-proliferative activity of Salvia menthifolia Ten. (formerly Salvia menthaefolia), Lamiaceae, on a glioblastoma cell line, since up to date poor therapeutic results have been reported for treatment of malignant glioblastoma. Methanol extracts from different anatomical parts of S. menthifolia were tested on DBTRG-05MG cell line by MTT assay. The most active primary stems extract was also evaluated for apoptosis induction. Results confirmed the anti-tumor property of all the organs and demonstrated that the primary stems extract induced apoptosis after 4 h with the highest values of DNA fragmentation after 6 to 24 h. Some extracts were also HPLC analyzed for polyphenols, althought activities could be due also to other constituents and to synergistic interactions. Rosmarinic acid, caffeic acid, luteolin-7-O-glucosyde and quercitrin were found in all the extracts. The good performance revealed for S. menthifolia towards this extremely aggressive human glioblastoma cell line confirms that the genus Salvia is a natural source of anti-tumor agents though there are great differences among the various species.

Extraction of antioxidant and antiproliferative ingredients from fruits of Rubus chingii Hu by active tracking guidance

“…It was reported that the methanol extracts from Salvia menthifolia exhibited antiproliferative activity against human glioblastoma cell line DBTRG-05MG. 18 The ethyl acetate fraction from Polytrichum commune L.ex Hedw also displayed a higher anti-tumor effect against L1210 cells than chloroform and butanol fractions. 19 Therefore, the bioactivity-guided separation of R. chingii was designed and four active compounds were isolated from the ethyl acetate fraction.…”

Investigation of phenolic profiles and antioxidant activities of some Salvia species commonly grown in Southwest Anatolia using UPLC-ESI-MS/MS

“…Ot is known that Salvia species have been used as infusions against simple diseases in Anatolian traditional medicine applications (Baytop, 1999). Many Salvia species have been reported for use in the treatment of diseases such as epilepsy, colds, bronchitis and tuberculosis (Dweck, 2000) as well as biological activities such as antioxidant, antimicrobial (Kelen & Tepe, 2008), anti-inflammatory (González-Chávez et al, 2017), antidiabetic (Eidi & Eidi, 2009), antitumor (Fiore et al, 2012), anti cancer (Jiang et al, 2017) ve antiviral activities (Šmidling et al, 2008). Additionally, Scholey et al (2008) examined the administration of a standardised Salvia extract to improve cognitive function in healthy older individuals and reported enhancement in cognative performance.…”

The identities of three plants of unknown origin revealed by ancient paintings

“…To justify this, Pasquale (1867) cited the unpublished plate in the Garden collections, in one of the rare citations of the plates after Tenore's time. Curiously, the little‐known name S. menthifolia appeared sporadically in medical papers, where its correct identity could be particularly useful (e.g., Fiore & al., 2012), as well as in nursery catalogues (https://www.bio-gaertner.de/pflanzen/Ziersalbeiarten).…”