In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Tonuci, Ligia R. S.; Melo, Nathalya Isabel de; Dias, Herbert Júnior; Wakabayashi, Kamila A. L.; Aguiar, Gabriela P.; Aguiar, Daniela P.; Mantovani, André Luis Lembi; Ramos, Rafael Corrêa; Groppo, Milton; Rodrigues, Vanderlei; Veneziani, Rodrigo Cássio Sola; Cunha, Wilson Roberto; Filho, Ademar A. Da Silva; Magalhães, Lizandra G.; Crotti, Antônio Eduardo Miller

doi:10.1590/s0102-695x2011005000202

Cited by 32 publications

(33 citation statements)

References 31 publications

(27 reference statements)

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“…Plants are an important source of biologically active compounds that can provide structures for the development of new drugs [37]. In recent years, an extensive attention to natural products as a treatment of neglected tropical diseases, including schistosomiasis, has been growing.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts againstSchistosoma mansoni

Yones

Badary

Sayed

et al. 2016

BioMed Research International

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Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S. mansoni infected mice for in vivo tests were obtained from Theodor Bilharz Research Institute, Cairo, Egypt. In vitro activity was manifested by significant coupled worms separation, reduction of motor activity, lethality, and ultrastructural tegumental alterations in adult worms. In vivo activity was manifested revealed by significant reduction of hepatic granulomas number and diameter, decreased number of bilharzial eggs in liver tissues, lowered liver inflammatory infiltration, decreased hepatic fibrosis, and inducible nitric oxide synthase (iNOS) expression. Ethanolic stem bark extract of edible pomegranate exhibited highest antischistosomal activities both in vitro and in vivo. Therefore, pomegranate showed a good potential to be used as a promising new candidate for the development of new schistosomicidal agents.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts againstSchistosoma mansoni

Yones

Badary

Sayed

et al. 2016

BioMed Research International

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“…The essential oil from T. erecta leaves displays schistosomicidal properties and is utilized as antihelminthic in the Amazonia region (Stasi and Hiruma-Lima, 2002;Tonuci et al, 2012). The monoterpenes ␣-terpinolene, (E)-ocimenone, limonene, (Z)-␤-ocimene, linalool, dihydrotagetone, piperitone, piperitenone and (E)-tagetone are the main chemical constituents of this essential oil (Baslas and Singh, 1981;Krishna et al, 2004;Ogunwande and Olawore, 2006;Sefidkon et al, 2004;Sharma et al, 1961;Singh et al, 2003;Tonuci et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity screening of essential oils in cancer cell lines

Oliveira

Alves

Damasceno

et al. 2015

Revista Brasileira de Farmacognosia

123

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a b s t r a c tThis study evaluated the cytotoxicity activity of the essential oils of Tagetes erecta L., Asteraceae (TE-OE), Tetradenia riparia (Hochst.) Codd, Lamiaceae (TR-OE), Bidens sulphurea (Cav.) Sch. Bip., Asteraceae (BS-OE), and Foeniculum vulgare Mill., Apiaceae (FV-OE), traditionally used in folk medicine, against the tumor cell lines murine melanoma (B16F10), human colon carcinoma (HT29), human breast adenocarcinoma (MCF-7), human cervical adenocarcinoma (HeLa), human hepatocellular liver carcinoma (HepG2), and human glioblastoma (MO59J, U343, and U251). Normal hamster lung fibroblasts (V79 cells) were included as control. The cells were treated with essential oil concentrations ranging from 3.12 to 400 g/ml for 24 h. The cytotoxic activity was evaluated using the XTT assay; results were expressed as IC 50 , and the selectivity index was calculated. The results were compared with those achieved for classic chemotherapeutic agents. TE-OE was the most promising among the evaluated oils: it afforded the lowest IC 50 values for B16F10 cells (7.47 ± 1.08 g/ml) and HT29 cells (6.93 ± 0.77 g/ml), as well as selectivity indices of 2.61 and 2.81, respectively. The major BS-EO, FV-EO and TE-EO chemical constituents were identified by gas chromatography mass spectrometry as being (E)-caryophyllene (10.5%), germacrene D (35.0%) and 2,6-di-tert-butyl-4-methylphenol (43.0%) (BS-EO); limonene (21.3%) and (E)-anethole (70.2%) (FV-EO); limonene (10.4%), dihydrotagetone (11.8%), ␣-terpinolene (18.1%) and (E)-ocimenone (13.0%) (TE-EO); and fenchone (6.1%), dronabinol (11.0%), aromadendrene oxide (14.7%) and (E,E)-farnesol (15.0%) (TR-EO). 2,6-di-tert-butyl-4-methylphenol (43.0%), (E)-anethole (70.2%) and ␣-terpinolene (18.1%), respectively. These results suggest that TE-OE may be used to treat cancer without affecting normal cells.

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“…This scenario emphasizes the increasing need for the development of novel and inexpensive drugs against schistosomiasis. In order to provide new hit/lead structures, which can be used in drug development to control schistosomiasis, the search for schistosomicidal compounds, mainly from natural sources, has been intensified in the last years [5–8]. …”

Section: Introductionmentioning

confidence: 99%

Anthelmintic Effects of Alkylated Diamines and Amino Alcohols againstSchistosoma mansoni

Fernandes

Júnior

Fernandes

et al. 2013

BioMed Research International

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Polyamines are substances involved in many aspects of cell growth, division, and differentiation. Because of the metabolic differences between host cells and parasite cells, polyamine metabolism has been considered as a potential target for the chemotherapy of parasitic diseases. The aim of this work was to evaluate the schistosomicidal activity of different N-alkylated diamines (3a–3h), amino alcohols (4a–4d), and glycosylated amino alcohols (10a–10d). Compounds were prepared by synthetic methods and submitted to in vitro evaluation against adult worms of Schistosoma mansoni. At 100 μM, 3b, 3e, and 3h as well as 4a, 4b, 4d, 10a, 10b, and 10d resulted in 100% mortality of adult schistosomes. Compound 3d (12.5 to 100 μM) caused the death of 100% of both male and female adult schistosomes, while 3f (12.5 to 100 μM) resulted in 100% mortality of only male adult worms, whereas no mortality in female worms was observed. Compounds 3d and 3f were also able to reduce viability and decrease production of developed eggs in comparison with the negative control group. Diamines 3d and 3f may represent useful lead compounds for further optimization in order to develop new schistosomicidal agents.

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In vitro schistosomicidal effects of the essential oil of Tagetes erecta

Cited by 32 publications

References 31 publications

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts againstSchistosoma mansoni

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts againstSchistosoma mansoni

Cytotoxicity screening of essential oils in cancer cell lines

Anthelmintic Effects of Alkylated Diamines and Amino Alcohols againstSchistosoma mansoni

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