Anti-inflammatory and analgesic potential of Caesalpinia ferrea

Lima, Sandrine Maria Arruda; Araújo, Larissa Cardoso Corrêa de; Sitônio, Marília Maria; Freitas, A. C. C.; Moura, Sirlene L.; Correia, Maria T.S.; Malta, Diana Jussara N.; Gonçalves-Silva, Teresinha

doi:10.1590/s0102-695x2011005000197

Cited by 22 publications

(28 citation statements)

References 18 publications

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“…In addition, the induction test for acetic acid at doses of 12.5, 25 and 50 mg/kg reduced the number of contortions. Furthermore, the study reports that in the formalin test, the effects presented from the extract appeared only in the second phase (Lima et al, 2012).…”

Section: Anti-inflamatory Analgesic and Antinoceptive Effectsmentioning

confidence: 99%

Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz: A review of the biological activities and phytochemical composition

Rhayanny¹,

Luiz²

2015

J. Med. Plants Res.

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Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz is a medicinal plant widely known in Brazil as "jucá" or "pauferro" that belongs to the Fabaceae family. The species is native to Brazil and is mainly found in the North and Northeastern regions. It has been studied for its biological activities and chemical composition. Scientific literature has reported that this species contains different extracts and/or isolated compounds which have antimicrobial, anti-inflamatory, analgesic, antioxidant and hypoglycemic properties, as well as others that are in popular use. The phytochemical literature reports on the presence of fatty acids, terpenoids, phenolic compounds and polysaccharides. However, further studies are necessary to find new bioactive molecules with biological relevance based on traditional medicine. The purpose of this review is to provide a broad and updated overview about the relevance of Libidibia ferrea species in regard to general aspects, traditional medicines, biological activities and chemical composition data.

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Section: Anti-inflamatory Analgesic and Antinoceptive Effectsmentioning

confidence: 99%

Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz: A review of the biological activities and phytochemical composition

Rhayanny¹,

Luiz²

2015

J. Med. Plants Res.

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“…The stem bark and pods are the parts of L. ferrea most commonly used in popular medicine, and is mainly used as an anti-inflammatory and anti-asthmatic aid. In addition, the literature reports the relationship between the tannins of this species and its several biological properties, these include: antimicrobial, anti-inflammatory and hypoglycemic properties [4][5][6][7][8][9] . Regarding the chemical composition of L. ferrea, the presence of flavonoids, coumarins, steroids and other phenolic compounds have already been reported 6,9,10 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Folin-Ciocalteu Method and Quantification of Total Tannins in Stem Barks and Pods from Libidibia ferrea (Mart. ex Tul) L. P. Queiroz

Galvão

Arruda

Bezerra

et al. 2018

Braz. arch. biol. technol.

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The stem bark and pods of "jucá" are widely used in Brazilian folk medicine and, despite their therapeutic relevancies, there are insufficient reports about their quality control. Both herbal drugs from the species are rich in tannins, which showed a lot of biological and economic interest. Thus, the purpose of this study was to evaluate the method for quantification of tannins in the stem bark and pods from L. ferrea. The performance of the method was tested against the influence of the most relevant parameters (reaction time; amount of drug; type and amount of precipitationagents; and, concentration of the reagents). The procedure was validated according to the literature. After optimization, the experimental conditions were established as: 30 min of reaction; λ of 760 nm; 1.0 mL of Folin-Ciocalteu; 29% of Na2CO3 (w/v); and, skin powder as complexion agent. The method validation showed that the instrumental response was linear and sensitive to the investigated analyte. The method presented the necessary precision (RSD < 2.19%) and accuracy (96.84%-109.13%), as recommended by the official codex. Moreover, the deliberate introduction of experimental variations showed the stability of the procedure error against external sources (RSD < 2.42%). In conclusion, the data demonstrated the suitability of the method and can be used as anappropriate analytical tool for quality control of herbal drugs from L. ferrea.

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“…Jucá fruits extracts have been reported to present relevant healing, antifungal, antimicrobial, anti-inflammatory, analgesic, antiulcer and cancer chemopreventive properties [26,[40][41][42][43][44]. Other relevant objectives of this work are the evaluation and elucidation of the relationships between extract compositions, extract loading yields, extract release behaviors from employed wound dressing materials, cytocompatibility with fibroblasts and macrophages, and anti-inflammatory ability against LPS-stimulated macrophages.…”

Section: Introductionmentioning

confidence: 99%

Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology

Dias

Rey‐Rico

Oliveira

et al. 2013

The Journal of Supercritical Fluids

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a b s t r a c t N-Carboxybutyl chitosan (CBC), collagen/cellulose (Promogran ® ) and hyaluronic acid-based (Hyalofill ® ) polymeric matrices/dressings were loaded with an extract obtained from jucá (Libidibia ferrea) and in order to develop wound dressings endowed with anti-inflammatory activity. Jucá fruits were subjected to supercritical fluid extraction (SFE) using CO 2 at 25 MPa and 50• C and the resulting extract was later incorporated into the above referred wound dressings by a supercritical fluid impregnation/deposition method (SSI). GC analysis revealed that the obtained SFE extract is particularly rich in unsaturated (52%) and saturated (26%) fatty acids as well as in terpenoids (13%) such as lupenone and gamma-sitosterol. Extract loading yields depended on the affinity of the hydrophobic extract for the specifically employed wound dressing material and was almost 2-fold greater for CBC than for the other two commercial wound dressings. The prepared extract-loaded dressings were cytocompatible with RAW 264.7 macrophages (viability > 85% at 24 h) and down-regulated the expression of TNF-␣ and IL-1␣ proinflammatory cytokines as well as the production of nitric oxide, which confirms the anti-inflammatory capacity of the employed jucá extract. Nevertheless, such effect was somehow counteracted by a proinflammatory activity that was exhibited by CBC. Prepared dressings presented a wide range of water vapor ((2.9-14.7) × 10 14 kg/(s m Pa)) and oxygen permeability (150 up to 830 barrer) which make them potentially suitable for the management of various wound types at different healing stages.

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Anti-inflammatory and analgesic potential of Caesalpinia ferrea

Cited by 22 publications

References 18 publications

Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz: A review of the biological activities and phytochemical composition

Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz: A review of the biological activities and phytochemical composition

Evaluation of the Folin-Ciocalteu Method and Quantification of Total Tannins in Stem Barks and Pods from Libidibia ferrea (Mart. ex Tul) L. P. Queiroz

Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology

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