Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Das, Kuntal; Kathiriya, Anil Kumar; P, Kumar E.; K, Benson M.; Einstein, John Wilking

doi:10.1590/s0102-695x2011005000189

Cited by 11 publications

(10 citation statements)

References 9 publications

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“…37 IU/L respectively) and total bilirubin (0.226±0.00 mg/dL 0.288±0.01 mg/dL respectively) content that were lesser than positive control, thioacetamide damaged rats. Histology of the liver sections of the animals treated with the extract also showed dose dependent reduction of necrosis 34 .…”

Section: Anti-ulcer Activitymentioning

confidence: 80%

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2012

IJPSR

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Many herbal remedies have been employed in various medical systems for treatment and management of different diseases. The plant Oxalis corniculata Linn. has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. β-sitosterol, betulin, 4-hydroxybenzoic acid, ethyl gallate, methoxyflavones, apigenin, and 7-O-β-D-glucopyranoside were previously isolated from the whole plant of Oxalis corniculata.linn. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant like flavanoids, tannins, phytosterols, phenol, glycosides, fatty acids, galacto-glycerolipid and volatile oil. The leaves contain flavonoids, iso vitexine and vitexine-2"-O-beta -Dglucopyrunoside. It is rich source of essential fatty acids like palmitic acid, oleic, linoleic, linolenic and stearic acids. It has been reported that the plant contains anti-inflammatory, anxiolytic, anticonvulsant, antifungal, antiulcer, antinociceptive, anticancer, antidiabetic, hepatoprotective, hypolipedemic, abortificient, antimicrobial and wound healing properties. The current study is therefore reviewed to provide requisite phytochemical and pharmacological detail about the plant.

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Section: Anti-ulcer Activitymentioning

confidence: 80%

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2012

IJPSR

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“…As per Drotman and Lawhorn [21] increased level of serum enzymes are indicative of cellular leakage and loss of functional integrity of cell membrane in liver. TAA causes significant increase in the level of serum SGOT, SGPT, ALP and Bilirubin which forms liver toxicity [22]. Achliya et al [23] have rightly reported that bilirubin is the conventional indicator of liver diseases.…”

Section: Resultsmentioning

confidence: 99%

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2018

RJLBPCS

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The present work was carried out to check hepatoprotective potency of ethanolic extract of Andrographis paniculata. The whole plant extract of A. paniculata was used for the treatment of toxicity induced in the liver of albino rat, Rattus norvegicus by using thioacetamide (TAA). Thioacetamide toxicity in the animal was manifested by the significant increase in the level of serum bilirubin, ALP, SGPT, and SGOT while significant decrease in liver protein. Administration of ethanolic extract of A. paniculata at different doses(200 mg and 250 mg/kg b. w. showed significant decrease in the level of serum bilirubin, ALP, SGPT, and SGOT but increase in the level of protein in the liver when compared with induced rats. These results thus proved the potential hepatoprotective effect of ethanolic extract of A. paniculata.

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“…In 2014, Sohail et al [62] developed an extraction method with different solvents to reduce the oxalates amount present in this plant. The MeOH extracts of the stem and leaves with a low oxalate content showed a good antioxidant activity in vitro (DDPH and β-carotene linoleate), and showed HPP activity compared against the hepatic damage caused by thioacetamide (aqueous and EtOH extracts) and against CCl 4 (MeOH) [63,64]; therefore, they evaluated the HPP activity in vivo against the OS caused by INH/RIF (100 mg/kg, each) in Wistar rats. The MeOH extract (stems and leaves) was administered orally for 21 days, at 400 mg/kg, using Sil (2.5 mg/kg) as PC.…”

Section: Open Access Freely Available Onlinementioning

confidence: 99%

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Ramírez-Marroquín¹,

Jiménez-Arellanes²

2019

Med Aromat Plants

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Tuberculosis is mainly treated with rifampicin, pyrazinamide, isoniazide, ethambutol and/or streptomycin; however, the first three cause hepato-and nephro-toxicity, then the patient abandons therapy. This cause contributes to the failure of the treatment and favors the appearance of drug-resistant strains. Currently, alternatives are being sought to counteract this hepatic-damage, and medicinal plants, natural compounds and/or biological products are of great interest. In this manuscript we describe current data on the hepato-protective effect from extracts of medicinal plants, compounds isolated from them and biological products that protect against liver damage caused by antitubercular (anti-TB) drugs caused by therapy in patients with tuberculosis (TB). The main consulted databases were: PubMed, Worldwidescience.org, and Scopus, including records between 2000 and 2018 years. Thus, we found many articles about hepatoprotective effect from medicinal plants and polyherbal preparations (Hepatoplus and Liv 52), the majority of these have an important effect (on preclinical study) due to their antioxidant compounds content. In addition, the hepatoprotective activity of biological products and/or natural compounds has been discussed and it should be noted that the quercetin (natural antioxidant compound)/ polyvinylpyrrolidone mixture protects against hepatic damage caused by therapy in patients with TB. Another interesting compound with good effect in TB patients is N-acetylcysteine (an oral marketed mucolytic drug) which could be repurposed as an hepatoprotective drug. We consider that these findings are of great interest for researchers and clinicians, also for the development of new agents as well as for the therapeutic use of hepatoprotective substances in patients with TB, which helps reduce the toxic effects that drugs cause.

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Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Cited by 11 publications

References 9 publications

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Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

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