Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats

Abstract

Abstract:In recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae) which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of 99m Tc-DTPA and its blood cells uptake. DTPA was labeled with 99m Tc radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of 99m Tc-DTPA in kidneys and in blood cells. 99m Tc-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of 99m Tc-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.

Drug interaction evaluation of [99mTc]Tc-ketoconazole uptake with ketoconazole administration in Candidiasis mice model

“…The pharmacological interaction process affects the biodistribution of the radiopharmaceutical due to the mechanism of action of the, toxicological interaction, pharmacokinetic interaction, and physical properties of the drug (Iii, et al, 1982). The latest research by Zora et al found that the administration of medicinal plants affected the biodistribution uptake of [ 99m Tc]Tc-DTPA in the kidney and bladder (Zora et al, 2012).…”