Reversal of CRF- and stress-induced anorexia by an ayurvedic formulation

Kulkarni, VS; Surana, Sanjay J.

doi:10.1590/s0102-695x2011005000166

Cited by 2 publications

(1 citation statement)

References 24 publications

(17 reference statements)

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“…Different extracts and fractions of Trikatu possess Antioxidant, [21] Antihyperlipidemic, [22] Antianorectic, [23] Antitumor, [24] Hepatoprotective, [25] Antimicrobial, [26][27][28] Anthelmintic, [29] Analgesic, [28] Antifungal, [28] Immunomodulatory, [30,31] Antiallergic, [32] Antiarthritic, [33] and Anti-inflammatory [34,35] activities.…”

Section: Other Pharmacological Activities Of Trikatumentioning

confidence: 99%

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Kaushik¹

2018

IJGP

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Trikatu, as per Ayurveda's Bhaisajyaratnawali is a compound herbal formulation containing three bitter herbs mixed together in equal quantities. Dried fruits of Piper nigrum (Maricha) and Piper longum (Peepli) and dried rhizomes of Zingiber officinale (Sunthi) are used to prepare this miraculous formulation. It is prescribed in Ayurvedic system of medicine for treatment of tastelessness, digestive impairment, and diseases of nose and throat such as chronic rhinitis/sinusitis, skin diseases, asthma, cough, frequent urination, obesity, and Filariasis. Trikatu is also added in various Ayurvedic formulations with a view to restore the disturbed "tridoshas-vatta, pitta and kapha." It calms down the increased Vata and Kapha and increases the Pitta. It has pungent (katu) taste, hot (ushna) potency, light (laghu) and dry (ruksha) quality, and digestive (amapachaka) therapeutic effect. Modern pharmacological studies also revealed that Trikatu possesses the capability to enhance the bioavailability of various phytoconstituents and synthetic drugs if incorporated with them thereby helping in achieving the therapeutic goals. Apart from traditionally known health benefits, Trikatu also possesses immunomodulatory, antiviral, expectorant, carminative, hypolipidemic, hypoglycemic, antiemetic, and anti-inflammatory potential. Simply it is concluded that Trikatu is a miraculous combination which is needed to be explored more exhaustively to solve the bioavailability issues of allopathic, ayurvedic, and other traditional systems of medicines.

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Section: Other Pharmacological Activities Of Trikatumentioning

confidence: 99%

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Kaushik¹

2018

IJGP

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Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation

et al. 2022

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Trikatu Churna (TC) comprising Zingiber officinale rhizome, Piper longum, and Piper nigrum fruit, is effective in treating liver diseases and has high nutraceutical values. However, the efficacy of TC in treating alcoholic liver disease (ALD) and its mechanism remain largely unknown. This study evaluated the hepatoprotective effects of different doses of TC as well as to identify the bioactive components and determine their mechanism of action against ethanol-induced ALD. A compound-target network analysis model of TC was established to identify its potential bioactive compounds and pathways that might regulate its hepatoprotective effects. Further, in-vivo studies were performed to validate the potential of TC (200 mg/kg and 400 mg/kg b.w.) in the treatment and management of ALD. The study revealed that both the dosages of TC demonstrate significant (p > 0.0001) hepatoprotective effects by improving body weight, total bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphate (ALP), total cholesterol, total protein, globulin, albumin, and liver morphology. The High-performance thin-layer chromatography (HPTLC) fingerprinting of TC showed the presence of piperine. Network pharmacology identifies the role of TC in regulating various signaling processes including Advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE), Hypoxia-inducible factors (HIF-1), Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kappa B), and Phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling to exert its anti-inflammatory, antioxidant and anti-apoptotic role in managing ALD. Based on the bioinformatics analysis, some of the key targets of TC were found to be Prostaglandin-Endoperoxide Synthase 2 (PTGS2) or Cyclooxygenase-2 (COX-2), Sirtuin 1 (SRT1), and caspase-3. These effects may serve as a novel therapeutic option for the treatment of ALD. These preclinical validation studies for the ethnopharmacological potential of TC in ALD treatment further paved the way for researchers to perform next-level translational and clinical studies. Further, in-depth experimental studies for the validation of these bioinformatics-based results will give a clearer picture of mechanisms.

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Reversal of CRF- and stress-induced anorexia by an ayurvedic formulation

Cited by 2 publications

References 24 publications

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Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation

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