Trikatu churna is one of the commonly used Ayurvedic formulations in the traditional system of medicine in India for the treatment of agnimandya, i.e. anorexia. Trikatu contains equal amounts of finely powdered rhizomes of Zingiber officinale Roscoe (Zingiberaceae) and fruits of Piper longum L. and Piper nigrum L. (Piperaceae). The chief objective of the study was to determine the antianorectic effects of three drugs individually and to compare these effects with the effect of Trikatu. The activity of the drugs was studied after anorexia was induced in rats by (1) physical stress arising from immobilization for 60 min; (2) intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS, 100 µg/kg body weight); and (3) intraperitoneal administration of fluoxetine (8 mg/kg body weight). Similar doses of the extracts were tested on freely feeding rats and on rats that had been deprived of food for 20 h. Corticotrophinreleasing factor (CRF, 0.3 µg/rat) can induce anxiogenic-like behavior and reduced food intake. This model was also studied, and the results were compared. The components of Trikatu churna failed to individually reverse the inhibition of feeding. In contrast, Trikatu churna pretreatment reversed stress-, fluoxetine-and CRF-induced anorexia. The study provides strong evidence of the synergistic action of Ayurvedic formulas and also proves the ability of Trikatu churna to reduce stress and CRF-induced anorexia.
A rhizome of Zingiber officinale R. commonly known as Ginger is one of the most popular anti-inflammatory drug in Indian traditional medicine. 6-gingerol is one of the constituent contributing in anti-inflammatory activity of Ginger. Ginger extract and 6-gingerol act as an anti inflammatory via inhibition of proinflammatory cytokines. Increase in proinflammatory cytokines is also responsible for the reduction in food intake resulting anorexia. The aim of the present study was thus to determine antianorectic activity of standardized hydroalcoholic extract of ginger and similarly the biomarker 6- gingerol was also studied to evaluate its contribution in antianorectic activity. Anorexia was induced by intraperitoneal administration of E.coli lipopolysaccharide (100µg/kg) and Fluoxetine (FLU 8mg/kg) in rats. The effect of same doses of the extract was also tested in freely feeding rats. Effect of ginger and 6- gingerol both were studied The results showed that at 200 and 400 mg/kg, ginger reversed the anorectic effect while 6- gingerol at 5mg/ kg require for the effect. Moreover the same doses did not modify the food intake in freely feeding rats. These findings provide strong evidence that ginger is ableto attenuate anorexia induced by proinflammatory cytokines mediators.
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