Phytochemical researches and antimicrobial activity of Clinopodium nubigenum Kunth (Kuntze) raw extracts

Abstract

Abstract:The essential oil of the species Clinopodium nubigenum (Kunth) Kuntze, Lamiaceae, was analyzed by GC-MS and GC-FID, taking into account the more recent literature. Among the seventy compounds identified, the majority are oxygenated monoterpenoids. The essential oil, tested for antimicrobial activity, resulted effective in vitro against Candida albicans. From the aqueous MeOH extract of the aerial parts of the plant two nonvolatile compounds, named schizonepetoside A and schizonepedoside C, have been isolated. They are rare glycosyl terpenoids, which were previously isolated from only one plant, but never found before in the genus Clinopodium.

Volatiles and seasonal variation of the essential oil composition from the leaves of Clinopodium macrostemum var. laevigatum and its biological activities

“…These molecules were not detected under our GC conditions. Gilardoni et al (2011) reported seventy volatiles dissolved in the essential oil from Clinopodium nubigenum, with pulegone (∼70%) and menthone (∼12%) as the most abundant compounds. High abundances of pulegone (∼35%) were found in the essential oil from Clinopodium odorum (Vásquez et al, 2014).…”

“…However, low weight amphipathic monoterpenoids could also participate in the stabilization of free radicals in polar solutions because of their glycoside forms http://dx.doi.org/10.1016/j.indcrop.2015.09.050 0926-6690/© 2015 Elsevier B.V. All rights reserved. (Gilardoni et al, 2011). However, in spite of the very nice smell of this plant and as far as we know, there is no published information on the volatile compounds confined in the essential oil, neither on the free volatiles released from intact leaves of C. macrostemum var.…”

Clinopodium nubigenum (Kunth) Kuntze essential oil: Chemical composition, antioxidant activity, and antimicrobial test against respiratory pathogens

“…The preliminary GC/MS study ( El-Seedi et al, 2008), these changes in chemical composition could be attributed to climatic differences, soil composition, vegetative cycles, plant age and cultivation conditions (Gilardoni et al, 2011).…”

“…This aromatic plant is also known with the synonyms of Thymus nubigenus Kunth, Micromeria nubigena (Kunth) Benth, and Satureja nubigena (Kunth) Briq (Gilardoni et al, 2011). According to Cantino and Wagstaff (1998), after making a generae reassessment, based on molecular data and some herbarium studies, they recommend that the genera Satureja and Micromeria should be considered in a narrow sense and restricted way for the Old World, while most of the specimens of the New World form a clade including the genera Clinopodium and Calamintha, all in order to group and facilitate further studies given their similarities.…”

“…Aiming at its medicinal usefulness, there are several reports of use as a hot infusion of flowers and leaves with anti-inflammatory, stomachal, anti-influenza and antiinfective activity against dysentery and attenuating menstrual syndromes (Gilardoni et al, 2011). They offer relief of general malaise and to counteract the cold (Ansaloni et al, 2010).…”