Therapeutic benefits of Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, in experimental models of pain and inflammation

Abstract

RESUMO: "Benefícios terapêuticos da Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, em modelos experimentais de dor e inflamação". A Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, é utilizada na medicina popular em processos dolorosos e inflamatórios. Para avaliar as atividades analgésica e anti-inflamatória desta planta, estudos foram realizados com o extrato etanólico (EE) da entrecasca (100-400 mg/kg). O tratamento oral único dos animais com o EE inibiu (200 e 400 mg/kg, p<0,01) o efeito do ácido acético e reduziu (100, 200 e 400 mg/kg, p<0,001) o efeito da formalina na segunda fase; entretanto, não apresentou efeito no teste da placa quente. A formação de edema e a migração de leucócitos para a cavidade peritoneal induzidas pela carragenina foram reduzidas pelo tratamento com o EE (100, 200 e 400 mg/kg, p<0,001). Desta forma conclui-se que o EE da Sideroxylon obtusifolium apresenta atividades antinociceptiva e anti-inflamatória, suportando seu uso popular no tratamento da dor e de doenças inflamatórias.Unitermos: anti-inflamatória, antinociceptiva, Sideroxylon obtusifolium, Sapotaceae. ABSTRACT:Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, is a plant with analgesic and anti-inflammatory activities used in folk medicine. In order to evaluate the actions of this plant, studies were performed on antinociceptive and antiinflammatory activities with the ethanol extract (EE) of inner bark (100-400 mg/kg). Oral treatment with the EE elicited inhibitory activity (200 and 400 mg/kg, p<0.01) on acetic acid effect and reduced (100, 200, and 400 mg/kg, p<0.001) the formalin effect at the secondphase, however it did not elicit any inhibitory effect on hot-plate test. Carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity were reduced with the EE at 100, 200, and 400 mg/kg (p<0.001). In conclusion, the EE of Sideroxylon obtusifolium shows antinociceptive and anti-inflammatory activities, supporting the folkloric usage of the plant to treat pain and various inflammatory diseases.

Antimicrobial Potential of Plant Extracts and Chemical Fractions of Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn on Oral Microorganisms

“…The presence of tannins and flavonoids in S. obtusifolium EC extract was also found in a study by Araújo-Neto et al, 33 corroborating the quantification of these compounds in this study. The ability of tannins to complex with proteins gives them the ability to precipitate these compounds helping, for example, in the inhibition S. mutans glycosyltransferase enzymes, as well as other inhibitory effects on fungi.…”

Antifungal potential ofSideroxylon obtusifoliumandSyzygium cuminiand their mode of action againstCandida albicans

“…obtusifolium, known as 'quixabeira', 'quixaba' or 'rompegibão', is a medicinal plant species native to the Brazilian Caatinga, which is a unique biome that has aroused attention for its exuberant and unexplored biodiversity. It is threatened with extinction mainly by the extraction of its bark in popular medicine to treat pain and inflammation (Ara ujo-Neto et al 2010). However, other parts of this plant seem to have an unexplored potential against oral microorganisms of clinical relevance, such as streptococci and yeasts.…”

Contribuição ao conhecimento e conservação da laranjinha

“…A planta inteira é usada contra infl amação ovariana e diabe tes (BELTRÃO et al, 2008). S. obtusifolium apresenta atividades antinociceptiva e anti-inflamatória, suportando seu uso popular no tratamento da dor e de doenças infl amatórias (ARAUJO-NETO et al, 2010).…”