Leishmanicidal activities of the extract from Blepharocalyx salicifolius (Kunth) O. Berg, Myrtaceae

Siqueira, Ezequias Pessoa de; Souza-Fagundes, Elaine M.; Sobral, Marcos; Alves, Tânia Maria de Almeida; Rabello, Ana; Zani, Carlos L.

doi:10.1590/s0102-695x2010000300020

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Futhermore, B. salicifolius displayed great bactericidal effects against Staphylococcus aureus and Escherichia coli species and fresh leaves had antispasmodic effects (Limberger et al 2001). It was also suggested to have a great potential for isolation of compounds active against Leishmania with low toxicity (de Siqueira et al 2010).…”

Section: Resultsmentioning

confidence: 99%

In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum, Trypanosoma cruzi and T. brucei gambiense

Charneau

Mesquita

Bastos

et al. 2015

Natural Product Research

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The threatened Brazilian Cerrado biome is an important biodiversity hotspot but still few explored that constitutes a potential reservoir of molecules to treat infectious diseases. We selected eight Cerrado plant species for screening against the erythrocytic stages of Plasmodium falciparum, human intracellular stages of Trypanosoma cruzi and bloodstream forms of T. brucei gambiense, and for their cytotoxicity upon the rat L6-myoblast cell line. Bioassays were performed with 37 hexane, ethyl acetate and ethanol extracts prepared from different plant organs. Activities against parasites were observed for 24 extracts: 9 with anti-P. falciparum, 4 with anti-T. cruzi and 11 with anti-T. brucei gambiense activities. High anti-protozoal activity (IC50 values < 10 μg/mL) without obvious cytotoxicity to L6 cells was observed for eight extracts from plants: Connarus suberosus, Blepharocalyx salicifolius, Psidium laruotteanum and Myrsine guianensis. Overall, studies of plant extracts will contribute to increase the biodiversity knowledge essential for Cerrado conservation and sustainable development.

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Section: Resultsmentioning

confidence: 99%

In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum, Trypanosoma cruzi and T. brucei gambiense

Charneau

Mesquita

Bastos

et al. 2015

Natural Product Research

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“…Myrtaceae (e.g., Pimenta pseudocaryophyllus and Blepharocalyx salicifolius), Rutaceae (e.g., Zanthoxylum chiloperone and Zanthoxylum zanthoxyloides), and the methanolic extract of the leaves of Cordia verbenaceae and Cordia fragrantissima (Boraginaceae) had activity against Leishmania spp. (Ferreira et al, 2002;Takahashi et al, 2004;Ahua et al, 2007;Braga et al, 2007;Corrêa, 2010;Siqueira et al, 2010). No studies have investigated the anti-Leishmanial activity of the Tiliaceae family, of which Luehea paniculata is a member.…”

Section: Mycobacterium Tuberculosis Campomanesia Xanthocarpa Andmentioning

confidence: 99%

Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil

Moura-Costa

Nocchi

Ceole

et al. 2012

Journal of Ethnopharmacology

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“…Ainda, os pesquisadores avaliaram a citotoxicidade destas frações em células mononucleares de sangue periférico humano e conseguiram identificar duas frações (F11 e F12) que apresentam atividade leishmanicida e baixa toxicidade celular, ou seja, promissoras para continuidade dos estudos em busca de novos fármacos para o tratamento de leishmanioses (SIQUEIRA et al, 2010). Frutos e folhas de Eugenia umbeliflora, espécie nativa da flora brasileira, que ocorre da Paraíba a Santa Catarina, são utilizadas popularmente no tratamento de infecções, inflamações e diabete.…”

Section: Plantas Como Fonte Para O Desenvolvimento De Medicamentos: Ounclassified

Potencialidade De Espécies Da Família Myrtaceae Como Fonte Para Obtenção De Novos Candidatos a Fármacos Para O Tratamento De Leishmanioses

Kauffmann

Ethur

2016

Cad. Pedagógico

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Resumo: Leishmanioses são doenças infecciosas causadas por leishmanias e transmitidas por vetores, classificadas como uma doença tropical negligenciada, as quais afetam principalmente populações pobres em países em desenvolvimento. O tratamento das leishmanioses é deficitário em eficácia e segurança, não há vacinas disponíveis e ocorre dificuldade no controle de vetores, o que impulsiona a busca por novas alternativas terapêuticas, entre as quais, plantas. Assim, este artigo apresenta a problemática das leishmanioses e estudos sobre atividade leishmanicida realizados com espécies pertencentes à família Myrtaceae.Palavras-chave: Doenças tropicais negligenciadas. Leishmanioses. Myrtaceae. Plantas Medicinais. POTENTIALITY OF SPECIES OF THE FAMILY MYRTACEAE AS SOURCE FOR OBTAINING NEW CANDIDATES FOR DRUGS FOR THE TREATMENT OF LEISHMANIASISAbstract: Leishmaniasis are infectious diseases caused by leishmania and transmitted by vectors, classified as a neglected tropical disease, which mainly affect poor people in developing countries. Treatment of leishmaniasis is deficient on efficacy and safety, there is no vaccine available and the control of vectors is difficult, which drives the search for new therapeutic alternatives, including plants. Thus, this article presents the problem of leishmaniasis and antileishmanial activity studies performed with species belonging to the Myrtaceae family.

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Leishmanicidal activities of the extract from Blepharocalyx salicifolius (Kunth) O. Berg, Myrtaceae

Cited by 4 publications

References 22 publications

In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum, Trypanosoma cruzi and T. brucei gambiense

In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum, Trypanosoma cruzi and T. brucei gambiense

Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil

Potencialidade De Espécies Da Família Myrtaceae Como Fonte Para Obtenção De Novos Candidatos a Fármacos Para O Tratamento De Leishmanioses

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