Investigação da atividade antihiperglicemiante da farinha da casca de Passiflora edulis Sims, Passifloraceae, em ratos diabéticos induzidos por aloxano

Abstract

RESUMO:O presente estudo objetivou a modelagem farmacodinâmica da ação antihiperglicemiante da farinha da casca de maracujá (Passiflora edulis Sims, Passifloraceae) em ratos diabéticos induzidos por aloxano. Os animais foram divididos em três grupos (n = 9): grupo diabético tratado com 20 mg/kg, 40 mg/kg ou 160 mg/kg da farinha. As amostras sanguíneas foram coletadas da veia lateral da cauda e a glicemia foi determinada com auxílio de um glucômetro em 0, 1, 2, 4 e 6 h após o tratamento via oral. Observou-se que o efeito antihiperglicemiante da farinha da casca de maracujá foi dependente da dose, obtendo um efeito expressivo observado em quatro horas para todas as doses, sendo mais pronunciado na dose de 160 mg/kg. O efeito, expresso como redução da glicemia basal em relação ao tempo zero, pode ser modelado através de um modelo dose-efeito clássico, o qual permitiu a determinação do efeito máximo (E max ) e da dose necessária para alcançar 50% deste efeito (DE 50 ). Após a modelagem dos dados, obteve-se um valor de E max = 58,41% e de DE 50 = 23,61 mg/kg. Esta abordagem pode permitir a comparação do efeito antihiperglicemiante de Passiflora edulis com outras espécies que apresentem atividade sobre a redução da glicemia, mediada pela presença de fibras solúveis.Unitermos: Passiflora edulis, fibras hidrossolúveis, atividade antihiperglicemiante, modelagem farmacodinâmica, aloxan.ABSTRACT: "Investigation of antihyperglycemic activity of Passiflora edulis Sims, Passifloraceae, in alloxan-induced diabetic rats". This study goals the pharmacodynamic modeling of anti hyperglycemic action of flour of Passion fruit bark (Passiflora edulis Sims, Passifloraceae) in alloxan-induced diabetic rats. The animals were divided into three groups (n = 9) that received different doses: 20, 40 or 160 mg/kg of flour. The blood samples were collected from the tail vein and the blood glucose was determined using a glucometer Prestige IQ in 0, 1, 2, 4 and 6 h after the oral treatment. It was observed that the effect of the flour of Passion fruit bark was dose dependent, getting an expressive effect observed in four hours from all doses tested, being more pronounced at the 160 mg/kg dose. This effect was expressed as reduction of basal blood glucose in respect to zero time and can be modeled through a classic dose effect model. It allowed the determination of maximum effect (E max ) and the necessary dose to reach 50% of this effect (ED 50 ). After the data modeling, it was gotten a value of E max = 58,41% and ED 50 = 23,61 mg/kg. This approach allows the comparison of antyhyperglicemic effect of Passiflora edulis with other species that present activity lowering the glycemia, through the presence of soluble fibers.Keywords: Passiflora edulis, hidrossoluble fibers, antihyperglycemic, pharmacodynamic model, alloxan.não-farmacológicas, principalmente o controle da dieta e medidas farmacológicas, as quais incluem primeiramente o uso de hipoglicemiantes orais e nos casos mais graves, reposição com insulina exógena.Assim, é indicado um consumo...

Effects of <i>Pereskia aculeata</i> Miller on the Biochemical Profiles and Body Composition of Wistar Rats

“…On the other hand, there are numerous plants that have a beneficial effect onglycemia. Braga et al (2010) [30] investigated the anti-hyperglycemic activity of Passiflora edulis Sims peel flour in diabeticmice and found a significant decrease in blood glucose levels, demonstrating the anti-hyperglycemic action of passion fruit peel flour. [31], who also used Passiflora edulis Sims, observed beneficial effects on serum glucose levels.…”

Repeated administration of an aqueous spray-dried extract of the leaves of Passiflora alata Curtis (Passifloraceae) inhibits body weight gain without altering mice behavior

“…The fruits barks of Passiflora edulis, a byproduct of juice industry, are popularly used as antihyperglycemic, and this effect was observed in rodents (Braga et al, 2010). Passiflora alata is comprised in many Brazilian phytomedicines used for sedative and anxiolytic purposes.…”

Evaluation of the Hypoglycemic Properties ofAnacardium humileAqueous Extract

“…All these therapies have limited efficacy and various side effects, and thus searching for new classes of compounds is essential to overcome these problems. Thus, it has increased the demand for low-cost alternatives to aid in controlling blood glucose levels, to prevent or delay the onset of complications related to diabetes, based on pharmaceutical ethnobotany [11]. …”