Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Abstract

RESUMO: "Efeito hipotrigliceridêmico de folhas de Morus alba L., Moraceae, em ratos hiperlipidêmicos". As folhas de amoreira branca Morus alba L., Moraceae, são utilizadas no Brasil na medicina popular para tratar febre, como protetor do fígado, para baixar a pressão e o colesterol. O extrato aquoso de folhas de M. alba foi administrado via oral através de gavagem em ratos hiperlipidêmicos com uma dieta enriquecida com colesterol (1%) com uma dose de 150 mg/kg/dia por quatorze dias que reduziu significativamente em 55,01% o nível de triglicerídios plasmáticos. Desta forma, o tratamento diminuiu o nível de triglicerídios e uma enzima hepática testada, demonstrando que extratos de Morus alba que tem sido popularmente utilizados possuem um grande potencial para se tornar um fitomedicamento. Unitermos: Morus alba, ratos hiperlipidêmicos, triglicerídios.ABSTRACT: Mulberry Morus alba L., Moraceae, leaves are used in Brazil medicines against fever, to protect the liver, to lower the blood pressure and cholesterol. The aqueous extract of leaves of M. alba given by oral route to hyperlipidemic rats with diet enriched by cholesterol (1% by weight) with dose of 150 mg/kg/day for forteen days reduced significantly by 55,01% the plasma triglycerides level. Therefore, the treatment not only decreased the plasma level of triglycerides but also affected a hepatic enzyme tested supportting the fact that the extracts of Morus alba that have been used by folk medicine have a great potential to be further developed into a phytomedicine.

In vitro and in vivo analyses of Morus alba Polish var. wielkolistna zolwinska leaf ethanol–water extract—antioxidant and hypocholesterolemic activities in hyperlipideamic rats

“…The addition of mulberry extract to the diet is preventing the inflammatory process. Our results are in line with Zeni and Dall'Molin who showed that the aqueous mulberry leaf extract leads to inhibition of liver damage in hyperlipidaemic rats [39]. In contrast, Katsube et al did not observe similar effect in their studies on rats [7].…”

Anti-obesity and hypolipidemic effects of Morus alba- A review

“…The aqueous extract of Mulberry leaves at a dose of 150 mg/kg/day, for 14 days, significantly decreased the triglycerides level by 55.01% in rats on high cholesterol diet (26) .…”

“…Moracin isolated from the leaves of Morus alba inhibited lipid peroxidation which strongly indicated its role as scavenger (26) .…”

Performance of Hybrid Chickens as Influenced by Phytogenic Extracted Meal-Supplemented Diet as Antibiotic Alternatives During Summer

“…Besides the effective compounds of mulberry leaves they are nontoxic and have natural therapeutic properties because they act as antioxidants, anti-stress agents and immunoenhancers, and have cholesterol-lowering and nephro-and hepato-protective properties (Yang et al, 2012;Devi et al, 2013). Numerous researches demonstrated that anthocyanins and flavonoids present in mulberry leaves can protect against atherosclerotic and coronary heart diseases via removing the metabolic free radicals, inhibiting the LDL oxidation and their hypolipidemic and hypocholesterolemic properties (Zeni & Molin, 2010;Valacchi et al, 2014). Also, Abd El-Hady et al (2017) who observed that decreased blood malondialdehyde and increased glutathione levels as Glutathione boosts white jas.ccsenet.org Vol.…”