Antinociceptive and bioactivity of leaves of Murraya paniculata (L.) Jack, Rutaceae

Abstract

RESUMO: "Antinociceptiva e bioatividade das folhas de Murraya paniculata (L.) Jack, Rutaceae". Os resultados dos estudos de atividade antinociceptiva e toxicológicos do extrato etanólico de Murraya paniculata (L.) Jack, Rutaceae são relatados. O extrato (nas doses de 250 e 500 mg/kg) produziu um alta atividade antinociceptiva na forma dose-dependente. O extrato também mostrou considerável toxicidade no teste de Artemia salina (DL50 = 32 µg/mL). Unitermos:Murraya paniculata, Rutaceae, contorções, analgesico, citotóxico. ABSTRACT:The results of antinociceptive and toxicological studies on the ethanol extract of the leaves of Murraya paniculata (L.) Jack, Rutaceae, are reported. The extract (250 and 500 mg/kg dosages) was found to produce a profound antinociceptive activity in a dose dependent manner. The extract showed considerable brine shrimp toxicity (LD 50 = 32 µg/mL).

Murraya paniculata (L.) Jack: A Potential Plant for Treatment of Toothache

“…At these two doses, the numbers of writhings were decreased, respectively, by 26.7 and 66.7%. In comparison, a standard antinociceptive drug, diclofenac, when administered at a dose of 25 mg/kg decreased the number of writhings by 82.7%, demonstrating that the leaves like the bark possesses phytoconstituents with significant pain-relieving potential [12].…”

Murraya paniculata(L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats

“…However, medicinal use of leaves in decoction or infusion is the most common use, but other parts of the plant have been used traditionally as the bark and the roots. In China, M. paniculata was used to regulate fertility (Black, ), antinociceptive effect (Sharker et al, ), as potential therapeutic applications for treatment of toothache (Rahmatullah, ) and analgesic activity (Fazal‐ur‐Rehman et al, ) and antimicrobial activity (Menezes et al, ). These activities correlated positively with the presence of secondary compound classes.…”

“…A chemical study of this plant collected in São Paulo, Brazil, showed that it had a different chemical profile, when compared with studies using plant material collected in Asian countries. It is reported to have antinociceptive and antiinflammatory (Narkhede et al, ; Podder et al, ; Sharker et al, ), antidiarrheal (Rahman et al, ), and hypoglycemic effects (Gautam et al, , ).…”

Graphene-encapsulated silica as matrix solid-phase dispersion extraction sorbents for the analysis of poly-methoxylated flavonoids in the leaves of Murraya panaculata (L.) Jack

“…So far the leaves of this plant have been proved to possess significant antinociceptive, antibacterial, antifungal, and antioxidant [1,2]. It is widely used and has a good curative effect on treating superficial gastritis, erosive gastritis and intestinal metaplasia [3].…”