A proposal for the quality control of Tanacetum parthenium (feverfew) and its hydroalcoholic extract

Chaves, J.; Costa, Fernando B. Da

doi:10.1590/s0102-695x2008000300009

Cited by 13 publications

(13 citation statements)

References 16 publications

(14 reference statements)

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“…Análises de controle de qualidade de matérias-primas vegetais e do fitoterápico são complexas, porém imprescindíveis para contribuir para a qualidade do medicamento (Ushirobira et al, 2004b;Bara et al, 2004;Bara et al, 2006;Chaves & Costa 2008;Engel et al, 2008;Paula et al, 2008;Alvarenga et al, 2009;Bueno & Bastos, 2009;Couto et al, 2009).…”

Section: Resultsunclassified

Determinação de taninos e metilxantinas no guaraná em pó (Paullinia cupana Kunth, Sapindaceae) por cromatografia líquida de alta eficiência

Sousa¹,

Alves²,

Paula³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:As sementes de guaraná (Paullinia cupana Kunth, Sapindaceae) são utilizadas como estimulante e os principais constituintes químicos são as metilxantinas e os taninos, tais como catequina e epicatequina. Este trabalho teve por objetivo investigar um método por cromatografia líquida de alta eficiência (CLAE) para quantificar, simultaneamente, cafeína, teofilina, teobromina, catequina e epicatequina em pó de guaraná. Os valores obtidos foram comparados com os resultados encontrados no método espectrofotométrico da Farmacopéia Brasileira IV ed. Pelo método cromatográfico, os teores de metilxantinas e taninos totais foram de 4,04% e 1,48%, respectivamente. Os teores de metilxantinas e taninos totais, obtidos pelo método espectrofotométrico, foram de 4,88% e 4,05%, respectivamente. Acredita-se que, nas condições experimentais empregadas, o método espectrofotométrico não foi específico, quantificando outras substâncias fenólicas presentes no guaraná. Portanto, sugere-se o emprego desse método cromatográfico no controle de qualidade do guaraná em pó, por ser preciso, sensível, específico e rápido. Unitermos:Controle de qualidade, planta medicinal, guaraná, cafeína, catequina, CLAE.ABSTRACT: "Determination of tannins and methylxanthines in powdered guarana (Paullinia cupana Kunth, Sapindaceae) by high performance liquid chromatography". The seeds of Paullinia cupana Kunth, Sapindaceae, are used as a stimulant and the main chemical constituents are the methylxanthines and tannins, as catechin and epicatechin. This study aimed to investigate a method by high performance liquid chromatography (HPLC) to quantify both caffeine, theophylline, theobromine, catechin and epicatechin in powdered of P. cupana. The values obtained were compared with the results of the spectrophotometric method of the Brazilian Pharmacopoeia IV ed. For the chromatographic method, the levels of methylxanthines and total tannins were 4.04% and 1.48%, respectively. The levels of methylxanthines and total tannins obtained by the spectrophotometric method, were 4.88% and 4.05%, respectively. It is believed that, under our experimental conditions, the spectrophotometric method was not specific and quantified others phenolic substances present in the P. cupana. Therefore we suggest the use of this chromatographic method in quality control of P. cupana powder, to be accurate, sensitive, specific and fast. INTRODUÇÃOO guaraná, Paullinia cupana Kunth é uma planta da família Sapindaceae, originária da região Amazônica, a qual possui clima tropical, quente e úmido. É amplamente utilizado na medicina tradicional brasileira, sendo empregada em bebidas caseiras e industriais, como tônico e estimulante. A parte utilizada é a semente seca e

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Section: Resultsunclassified

Determinação de taninos e metilxantinas no guaraná em pó (Paullinia cupana Kunth, Sapindaceae) por cromatografia líquida de alta eficiência

Sousa¹,

Alves²,

Paula³

et al. 2010

Rev. bras. farmacogn.

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“…Santin was isolated from the T. parthenium powder (aerial parts) according to a previously reported method (Chaves, Da Costa, 2008).…”

Section: Chromatographic Standardsmentioning

confidence: 99%

“…Powdered aerial parts of T. parthenium were purchased from Galilee Herbal Remedies (Kibbutz Kfar Hanassi, Israel) and submitted to several analyses in order to certificate its authenticity (Chaves, Da Costa, 2008).…”

Section: Plant Materialsmentioning

confidence: 99%

Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L: )

Chaves

Costa

Freitas³

2009

Braz. J. Pharm. Sci.

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Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids. So far, there are no studies on standardization of pre-formulations or phytomedicines containing this herb. The present study aimed at developing a pre-formulation using a standardized spray-dried extract of feverfew and further designing and standardizing enteric coated tablets. In this work, the spray-dried extract of feverfew was evaluated for its parthenolide, santin and total flavonoid content, parthenolide solubility, particle size, tapped density, hygroscopicity, angle of repose and moisture content. Tablets containing the spray-dried extract were tested for their average weight, friability, hardness, and disintegration time. The total flavonoid and parthenolide contents in the spray-dried extract were 1.31 % and 0.76% w/w, respectively. The spray-dried extract presented consistent pharmacotechnical properties and allowed its tableting by direct compression. Tablet properties were in accordance with the proposed specifications. The procedures described herein can be used to prepare and evaluate pre-formulations of feverfew with adequate properties for the development of a high-quality phytomedicine.Uniterms: Enteric coated tablets. Flavonoids. Parthenolide. Phytomedicine. Spray-dried extract. Tanacetum parthenium.Tanacetum parthenium (tanaceto) é uma planta medicinal comercializada no mundo todo para tratamento de enxaqueca. Seu efeito farmacológico é creditado principalmente à lactona sesquiterpênica partenolídeo e flavonóides. Até o momento não existem estudos sobre a padronização de pré-formulações ou o desenvolvimento de fitoterápicos com tanaceto. Logo, o objetivo deste trabalho foi obter comprimidos de revestimento entérico a partir de extrato seco e padronizado de tanaceto. Neste trabalho, o extrato seco do tanaceto obtido pelo método de spray drying foi avaliado quanto ao teor de partenolídeo, presença da santina, teor de flavonóides totais, solubilidade do partenolídeo, tamanho de partícula, ângulo de repouso, densidade, análise higroscópica e teor de umidade. A partir do extrato seco obtiveram-se comprimidos que foram revestidos em leito de jorro. Os comprimidos revestidos foram avaliados com relação ao peso médio, friabilidade, dureza e desintegração. O teor de flavonóides totais e de partenolídeo no extrato seco foram 1,31% e 0,76% (p/p), respectivamente. O extrato seco apresentou características farmacotécnicas satisfatórias permitindo a obtenção de comprimidos pelo método de compressão direta. As propriedades dos comprimidos revestidos estão de acordo com as especificações da literatura. Os procedimentos utilizados nesse trabalho podem ser utilizados para obter extrato seco e fitoterápicos de T. parthenium com alto padrão de qualidade.

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“…It was observed that, in the last years, it has been an increasing interest by the large companies and some governments in such products, stimulating their standardization and the development of reliable quality control analytical methodologies to support their safety and efficacy (WHO, 1998;Calixto, 2000;Springfield et al, 2005;Ferrante et al, 2007;Migliato et al, 2007;Chaves & Costa, 2008;Engel et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines

Bueno¹,

Bastos²

2009

Rev. bras. farmacogn.

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A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines ABSTRACT: This work describes a full validation of a capillary gas chromatography analytical methodology using internal standardization for the quantification of coumarin (1,2-benzopyrone) in guaco (Mikania glomerata Spreng -Asteraceae) products: syrup, plant and its extract, including the stability study of the phytomedicine. For the analysis, it was used an HP-5 capillary column (30 m x 0.32 mm x 0.25 µm), hydrogen at a flow rate of 1.8 mL/min and the increasing temperature gradient was: 100 °C to 250 °C, 15 ºC/min. The temperature of injector (split 1:20) and detector were kept at 250 °C and 270 °C, respectively. The retention times of the standards for the above conditions were 2.86 minutes for 1, 2, 3, 4-tetramethylbenzene, 4.45 min for piperonal (internal standards), and 5.36 minutes for coumarin. After extraction procedure, the recovery of coumarin determined for plant raw material was 101.6 %, while for syrup it was 100.8 %. Detection and quantification limits were 0.5 µg/mL and 1.5 µg/mL, respectively. Precision was determined for all samples and the results were lower than 2.5 %. The total amount of coumarin in plant raw material, its extract and syrup were 0.38 % w/w, 1.33 mg/mL and 0.143 mg/mL, respectively.

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A proposal for the quality control of Tanacetum parthenium (feverfew) and its hydroalcoholic extract

Cited by 13 publications

References 16 publications

Determinação de taninos e metilxantinas no guaraná em pó (Paullinia cupana Kunth, Sapindaceae) por cromatografia líquida de alta eficiência

Determinação de taninos e metilxantinas no guaraná em pó (Paullinia cupana Kunth, Sapindaceae) por cromatografia líquida de alta eficiência

Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L: )

A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines

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