Atividade analgésica e antiedematogênica de Polygala paniculata L. (Polygalaceae) selvagem e obtida por micropropagação

Nogueira, F.L.P.; Fernandes, S.B.O.; Reis, G.M.; Matheus, Maria Eline; Fernandes, Patrícia Dias; Lage, Celso Luiz Salgueiro; Menezes, Fábio S.

doi:10.1590/s0102-695x2005000400009

Cited by 11 publications

(12 citation statements)

References 19 publications

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“…This method was used for many author like Nogueira et al (2005), Sharma et al (2011) and Sathesh et al (2010). The tail immersion test was performed by immersing, gently, the tail of the mice in warm water (55 ± 0.5°C).…”

Section: Tail Immersion Testmentioning

confidence: 99%

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Analgesic activity of Ruta graveolens L. (Rue) extracts

Cunha¹,

Melo²,

Magri³

et al. 2015

Afr. J. Pharm. Pharmacol.

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The knowledge of pharmacological activity is mainly derived from the use that the population makes of plants. Rue (Ruta graveolens L.) is popularly used with a degree of mysticism due to its antiinflammatory, healing, sedative and antispasmodic characteristics. In an attempt to confirm the wellknown analgesic effects, the present study evaluated Rue extracts in animal models. Two organic extracts were produced and orally administered to mice, approximately 30 min before the tail immersion test in warm water (55 ± 0.5°C). The results reveal a small chronic analgesic effect and a high effect in acute essay (62.1% of pain inhibition) especially observed in the hexane extract, supporting the hypothesis of the use of this plant as having analgesic activity. However, the reports of the population about its analgesic activity should be caused also by its anti-inflammatory characteristics and the presence of compounds related in literature as analgesics. Further experiments should be done to better determine the dose-response analgesic effect of R. graveolens extracts.

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Section: Tail Immersion Testmentioning

confidence: 99%

“…In this study, a single treatment was performed as acute essay, and a five day treatment as a subchronic essay (five-day treatment). Through the equation that relates the time of tail removal and the baseline value with the cutoff value, the pain inhibition (PI, percentage inhibition) could be calculated (Nogueira et al, 2005):…”

Section: Tail Immersion Testmentioning

confidence: 99%

Analgesic activity of Ruta graveolens L. (Rue) extracts

Cunha¹,

Melo²,

Magri³

et al. 2015

Afr. J. Pharm. Pharmacol.

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“…In vitro germination procedures were according to Nogueira et al, 2005. Nodal segments excised from in vitro seedlings were inoculated in 141 x 72 mm jars: 5 explants per jar containing 50 mL of MS (Murashige & Skoog, 1962) ).…”

Section: Culture Medium and In Vitro Conditionsmentioning

confidence: 99%

“…This volatile is the main component of Gelol ® , a common medicine in Brazil. Previous studies have shown scientific evidence for its analgesic, antiedematogenic and gastroprotective activities (Nogueira et al, 2005;Lapa et al, 2007;Lorenzi & Matos, 2008).…”

Section: Introductionmentioning

confidence: 97%

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Polygala paniculata: um recurso de salicilato de metila produzido por cultura de tecidos vegetais

Victório

Carriço²,

Lage³

2011

Rev. Ceres

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RESUMOPolygala paniculata: um recurso de salicilato de metila produzido por cultura de tecidos vegetais O estabelecimento de cultura in vitro de Polygala paniculata L. permitiu a propagação rápida de matéria-prima vegetal sob condições assépticas e padronizadas. As plantas in vitro foram submetidas à extração e destilação simultâneas (EDS) e a composição química do óleo essencial foi analisada por CG/DIC e CG/EM. Foram avaliados os efeitos de BAP (6-benzilaminopurina) sobre o desenvolvimento in vitro e produção de voláteis em P. paniculata. A principal característica do óleo essencial consistiu na presença marcante de salicilato de metila. Plantas cultivadas em meio controle MS (Murashige & Skoog) produziram mais do que 80% de salicilato, enquanto o uso de BAP, reduziu a produção de salicilato de metila a 71% e 21% para as concentrações de 2 e 4 mg L -1 , respectivamente. A cultura de tecidos de P. paniculata pode ser indicada como fonte de salicilato de metila. The establishment of Polygala paniculata L. tissue culture allowed a rapid propagation of raw plant material under aseptic and standardized conditions. Plantlets were subjected to simultaneous distillation-extraction (SDE) and volatiles composition analyzed by GC/FID and GC/MS. The effect of BAP (6-benzylaminopurine) on in vitro development and volatiles production was evaluated. The main feature of volatile compounds was the significant amount of methyl salicylate. Plantlets cultured on control MS (Murashige & Skoog) medium showed more than 80% of salicylate, while the addition of BAP at 2 and 4 mg L -1 concentrations reduced methyl salicylate production to 71% and 21%, respectively. Tissue culture of P. paniculata proved to be a potential source of methyl salicylate. Palavras

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