Estudo químico-biológico dos óleos essenciais de Hyptis martiusii, Lippia sidoides e Syzigium aromaticum frente às larvas do Aedes aegypti

Abstract

"Chemical-biological study of the essential oils of Hyptis martiusii, Lippia sidóides and Syzigium aromaticum against larvae of Aedes aegypti and Culex quinquefasciatus." The interest for a biological assay against larvae of Aedes aegypti and Culex quinquefasciatus is due to the fact that these species are distributed by the whole national territory, being therefore an activity carried out by countless researchers of Brazil. The essential oils of Syzigium aromaticum, Hyptis martiusii and Lippia sidoides were tested in the combat of the transmitter of the dengue and of the fi lariosis, using larvae of third stadium were exposed in triplicate to different concentrations (1000, 500, 250, 100, 50, 25 and 10 ppm). The larvicidal activity was observed after ten minutes of the beginning of the treatment, in the end showed very signifi cant results, with mortality potentials of up to 100% of the tested larvae, indicating accentuated toxical effects in some representatives of the volatile compounds present in the oils. For the oils of S. aromaticum, L. sidoides and H. martiusii DL 50 of 1,0; 1,0 and 8,0 ppm, respectively, were observed. Keywords:Aedes aegypti, Culex quinquefasciatus, Hyptis martiusii, Lippia sidoides, Syzigium aromaticum, essential oil, larvicidal activity. INTRODUÇÃOO dengue é uma doença infecciosa aguda de curta duração podendo assumir formas graves e letais que vem preocupando as autoridades médico sanitárias de todo o mundo. É transmitida pelos culicídeos do gênero Aedes, especifi camente pela picada do mosquito fêmea infectado. Aedes aegypti é o principal vetor de dengue no mundo, sendo que essa espécie está amplamente distribuída nas regiões tropicais e subtropicais. No Brasil sua existência é conhecida desde o século XVII (Halsted et al., 1997).Nos últimos anos o número de casos registrados e de mortes vítimas da dengue aumentou, visto que o mosquito se tornou resistente aos inseticidas convencionais (Hemingway et al., 2000). Sabe-se que a maneira mais efi caz e ideal para o controle do dengue

Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

“…It is native to Europe and was brought by settlers to Brazil, where it is cultivated as medicinal plant in gardens [6, 7]. …”

Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae)

“…In the Northeast region of Brazil, the leaves of Hyptis martiusii is used against intestinal and stomach diseases (Agra et al, 2008). Antimicrobial, antitumoral, cytotoxic and insecticidal activities were identified (Costa-Lotufo et al, 2004;Costa et al, 2005;Araújo et al, 2006;Coutinho et al, 2008), although no antiulcerogenic activity of the essential oil this species has been reported in the literature. The aim of the present study was to evaluate the antiulcerogenic activity of the essential oil of the leaves of Hyptis martiusii.…”

Gastroprotective and Ulcer Healing Effects of Essential Oil of Hyptis martiusii Benth. (Lamiaceae)

“…Few investigations of the pharmacological properties of Hyptis martiusii are described in the literature, including cytotoxic and antiproliferative effects on certain tumor cell lines [5], [6], insecticidal activity against larvae of Aedes aegypti and Culex quinquefasciantus [7], antimicrobial activity against resistant strains of Staphylococcus aureus and Escherichia coli [8] and antioxidant activity [9]. In addition, our laboratory previously reported the antiulcerogenic activity in models of acute gastric ulcers and potent antisecretory activity in the essential oil of Hyptis martiusii leaves [10].…”