Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

Abstract

The murine model of OVA-induced immediate allergic reaction was used to evaluate the effectiveness of intraperitoneal sub-acute treatment with the leaf hydroalcoholic extract of Cissampelos sympodialis (AFL) in the anaphylactic shock reaction, IgE production and the background proliferative response. BALB/c mice treated with AFL ranging from 200 to 400 mg/kg/day for 5 days before and during OVA-sensitization strongly reduced the animal death and promoted reduction in total and OVA-specifi c serum IgE level. Spleen cells from AFL-treated sensitized animals showed a decreased proliferative background response when compared with non-sensitized animals. These results demonstrated that sub-acute intraperitoneal treatment with Cissampelos sympodialis extract has an anti-allergic effect.

Warifteine, a bisbenzylisoquinoline alkaloid, decreases immediate allergic and thermal hyperalgesic reactions in sensitized animals

“…The warifteine-treatment reduced these responses. These results corroborate with previously data [32,33] that showed that the C. sympodialis extract also inhibited the IgE production and anaphylactic shock reaction in OVA-sensitized BALB/c mice adding support to the interpretation that the alkaloid possesses anti-allergic properties.…”

Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma

“…These findings, together with previous reports of this plant and warifteine inhibiting anaphylactic shock reaction in OVA sensitized mice, allergic pleurisy and pulmonary inflammation; suggest their therapeutic potential as anti-allergic and anti-asthmatic [9,26,10]. This alkaloid also reduced mast cell degranulation and hyperalgesia response in rats [12].…”

Cissampelos sympodialis (Menispermaceae): A Novel Phytotherapic Weapon Against Allergic Diseases?

“…However, the same treatment was not able to inhibit the anaphylactic shock induced by compound 48/80. These data show that the effect of the extract is dependent on mechanisms involving IgE production (Bezerra-Santos et al, 2005).…”