Efeitos agudos dos extratos hidroalcoólicos do alho (Allium sativum L.) e do capim-limão (Cymbopogon citratus (DC) Stapf) sobre a pressão arterial média de ratos anestesiados

Singi, Glenan; Damasceno, Dênis Derly; DAndréa, Éverton D.; Silva, G.A.

doi:10.1590/s0102-695x2005000200004

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…Some species analyzed applying a similar assay used in the present study also showed hypotensive activity (Singi et al, 2005;Soncini et al, 2011). Soncini et al (2011) reported that aqueous extract of Averrhoa carambola L. (Oxalidaceae) showed a dosedependent pressure reduction.…”

Section: Resultssupporting

confidence: 66%

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In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae species

Martins

Pacheco

Perini

et al. 2013

Braz. J. Pharm. Sci.

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In 1820, French naturalist August Saint Hillaire, during a visit in Espírito Santo (ES), a state in southeastern Brazil, reported a popular use of Cyperaceae species as antidote to snake bites. The plant may even have a hypotensive effect, though it was never properly researched. The in vitro inhibitory of the angiotensin converting enzyme (ACE) activity of eigth ethanolic extracts of Cyperaceae was evaluated by colorimetric assay. Total phenolic and flavonoids were determined using colorimetric assay. The hypotensive effect of the active specie (Rhychonospora exaltata, ERE) and the in vivo ACE assay was measured in vivo using male Wistar Kyoto (ERE, 0.01-100mg/kg), with acetylcholine (ACh) as positive control (5 µg/kg, i.v.). The evaluation of ACE in vivo inhibitory effect was performed comparing the mean arterial pressure before and after ERE (10 mg/kg) in animals which received injection of angiotensin I (ANG I; 0,03, 03 and 300 µg/kg, i.v.). Captopril (30 mg/kg) was used as positive control. Bulbostylis capillaris (86.89 ± 15.20%) and ERE (74.89 ± 11.95%, ERE) were considered active in the in vitro ACE inhibition assay, at 100 µg/mL concentration. ACh lead to a hypotensive effect before and after ERE's curve (-40±5% and -41±3%). ERE showed a dose-dependent hypotensive effect and a in vivo ACE inhibitory effect. Cyperaceae species showed an inhibitory activity of ACE, in vitro, as well as high content of total phenolic and flavonoids. ERE exhibited an inhibitory effect on both in vitro and in vivo ACE. The selection of species used in popular medicine as antidotes, along with the in vitro assay of ACE inhibition, might be a biomonitoring method for the screening of new medicinal plants with hypotensive properties.Uniterms: Cyperaceae/species/pharmacognosy. Cyperaceae/species/in vitro inhibitory activity. Cyperaceae/species/in vivo hypotensive effect. Angiotensin converting enzyme/in vitro inhibitory. Flavonoids/determination. Em 1820, o naturalista francês August Saint Hillaire, durante uma visita ao Espírito Santo (ES), Estado do sudeste do Brasil, relatou o uso popular de espécies de Cyperaceae como antídoto para picadas de cobra. As espécies podem possuir efeito hipotensor, embora nunca tenham sido devidamente pesquisadas. A inibição in vitro da atividade da enzima conversora da angiotensina (ECA) de oito extratos etanólicos de Cyperaceae foi avaliada por ensaio colorimétrico. Totais de fenólicos e flavonóides foram determinados utilizando ensaio colorimétrico. O efeito hipotensor da espécie ativa (Rhychonospora exaltata, ERE) no ensaio de ECA in vitro foi avaliada in vivo utilizando-se machos Wistar Kyoto (ERE, 0.01-100 mg/kg), com a acetilcolina (ACh), como controle positivo (5 µg/kg, iv). A avaliação do efeito inibidor da ECA in vivo foi realizado comparando-se a pressão arterial média, antes e após ERE (10 mg/kg) nos animais que receberam injeção de angiotensina I (Ang I, 0,03, 03 e 300 µg/kg, iv). Captopril (30 mg/kg) foi utilizado como controle positivo. Bulbostylis capillaris (86,89±15,20%) e ERE (7...

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Section: Resultssupporting

confidence: 66%

“…Soncini et al (2011) reported that aqueous extract of Averrhoa carambola L. (Oxalidaceae) showed a dosedependent pressure reduction. The hypotensive activity of hydroalcoholic extracts of garlic (Allium sativum L.) and lemon-grass (Cymbopogon citratus (DC) Stapf) were reported by Singi et al (2005).…”

Section: Resultsmentioning

confidence: 99%

In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae species

Martins

Pacheco

Perini

et al. 2013

Braz. J. Pharm. Sci.

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“…Several pharmacological effects were studies such as: analgesic, sedative/hypnotic, anxiolytic, anticonvulsant (Viana et al, 2000;Blanco et al, 2009). Some studies have shown that the endovenous administration of aqueous and hydroalcoholic extracts of leaves of C. citratus present anti-hypertensive effect in rats (Carbajal et al, 1989;Singi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. Stapf, Poaceae, in rats

Moreira¹,

Bastos²,

Blank³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Composição química e efeitos cardiovasculares do óleo essencial de Cymbopogon citratus DC. Stapf, Poaceae, em ratos". C. citratus é utilizada na medicina popular para tratar hipertensão. Este trabalho investigou a composição química e os efeitos cardiovasculares do óleo essencial do C. citratus (OECC). Foram identificados oito constituintes no OECC, sendo geranial o majoritário (43,08%). Em ratos, o OECC (1, 5, 10 e 20 mg/kg, i.v.) induziu hipotensão e bradicardia que foram atenuadas pela atropina e tiopental sódico, mas não por L-NAME ou indometacina. Em anéis de artéria mesentérica de ratos pré-contraídos com fenilefrina, o OECC (1 a 3000 µg/mL) induziu relaxamento que não foi afetado após remoção do endotélio, após TEA ou em anéis pré-contraídos com KCl (80 mM). Além disso, o OECC (1000 µg/mL) não induziu efeito adicional sobre o relaxamento máximo da nifedipina (10 µM). Em conclusão, o OECC induz hipotensão possivelmente devido à redução da resistência vascular que pode ser causada por inibição do influxo de Ca 2+ , e bradicardia provavelmente devido à ativação de receptores muscarínicos cardíacos.Unitermos: Cymbopogon citratus, óleo essencial, efeitos cardiovasculares, ratos. ABSTRACT:Cymbopogon citratus DC. Stapf, Poaceae, is used in the folk medicine for hypertension treatment. This work investigated the chemical composition and cardiovascular effects in rats of C. citratus essential oil (EOCC). A phytochemical screening demonstrated the presence of eight constituents, being geranial the major compound (43.08%). In rats, EOCC (1, 5, 10, and 20 mg/kg, i.v.) induced transient hypotension and bradycardia that were attenuated by atropine and sodium thiopental, but not by L-NAME or indomethacin. In rings of rat superior mesenteric artery pre-contracted with phenylephrine, EOCC (1 to 3000 µg/mL) induced relaxation that was not affected after removal of the endothelium, after TEA or in rings pre-contracted with KCl (80 mM). Furthermore, EOCC (1000 µg/mL) was not able to induce additional effect on maximal relaxation of nifedipine (10 µM). In conclusions, EOCC induces hypotension, possibly by reduction in vascular resistance caused by inhibition of the Ca 2+ influx, and bradycardia probably due to an activation of cardiac muscarinic receptors.

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“…About 56 species are aromatic and some of them of medicinal, pharmacological and industrial importance (Morais et al, 2005;Tôrres et al, 2005;Vendruscolo et al, 2005;Barbosa-Filho et al, 2005;Singi et al, 2005;Pansera et al, 2003). Two species of Cymbopogon are known according to their region.…”

Section: Introductionmentioning

confidence: 99%

Influence of season, harvest time and drying on Java citronella (Cymbopogon winterianus Jowitt) volatile oil

Blank¹,

Costa²,

Arrigoni-Blank³

et al. 2007

Rev. bras. farmacogn.

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RESUMO: "Infl uência da estação, do horário de colheita e da secagem no óleo essencial de citronela de java (Cymbopogon winterianus Jowitt)". Citronela de Java (Cymbopogon winterianus Jowitt) pertence à família Poaceae. Óleo volátil de citronela de Java apresenta atividade repelente, antimicrobiana e acaricida. Sabe-se que fatores agronômicos têm grande efeito sobre a qualidade e quantidade de metabólitos essenciais. Por isso é importante a determinação dos níveis ótimos dos fatores agronômicos que afetem o crescimento e a produção. Horário de colheita e secagem são fatores agronômicos muito importantes. O presente estudo foi conduzido na Fazenda Experimental do Departamento de Engenharia Agronômica da Universidade Federal de Sergipe, no período de 2002-2003, usando o delineamento de blocos casualizados e um experimento em esquema fatorial com três repetições. O capim citronela foi cultivado usando espaçamento de 60 cm entre linhas e 60 cm entre plantas. Realizaram-se colheitas de manhã, meio dia e à tarde, às 9:00 h, 12:00 h e 15:00 h, nas quatro estações do ano. Usaram-se folhas frescas e secas no experimento. Para estudar os efeitos do horário de colheita e secagem avaliaram-se as seguintes características: rendimento de biomassa seca e fresca (kg/ha), umidade (%), teor (%) e rendimento (L/ha) de óleo essencial, e a composição química do óleo essencial. Mudanças sazonais apresentaram efeito signifi cativo sobre o rendimento de biomassa fresca e seca, e teor e rendimento de óleo. Rendimentos máximos de óleo essencial foram observados às 9:00 h durante o verão, inverno e primavera. O teor de óleo essencial foi infl uenciado pela estação doa ano e secagem, mas não foi infl uenciado pelo horário de colheita. Unitermos:Cymbopogon winterianus, colheita, pós-colheita, geraniol, citronelal, citronelol.ABSTRACT: Java citronella (Cymbopogon winterianus Jowitt) is member of the Poaceae family. Java citronella volatile oil has been reported to be among the volatile oils, showing repellent, antimycotic, and acaricide activities. It has been known that agronomical factors have a great effect on both the quality and quantity of essential metabolites. For this reason, it is necessary to determine optimum levels of agronomical factors affecting plant growth and production. Harvest time and drying are very important agronomical factors. This study has been conducted in the Research farm of the "Universidade Federal de Sergipe", Agronomical Engineering Department along 2002-2003 on the base of factorial experiment in randomized complete block design with three replications. Java citronella was cultivated in a 60 x 60 cm space. Early, midday, and late harvest at 9:00 h, 12:00 h, and 15:00 h were conducted on four different seasons. Fresh and dried leaves were used on the experiments. In order to study the effects of harvest time and drying, yields of dry and fresh herbage (kg/ha), moisture content (%), volatile oil content (%) and yield (L/ ha), and chemical composition of the volatile oil were measured. Seasonal changes had sig...

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Efeitos agudos dos extratos hidroalcoólicos do alho (Allium sativum L.) e do capim-limão (Cymbopogon citratus (DC) Stapf) sobre a pressão arterial média de ratos anestesiados

Cited by 20 publications

References 12 publications

In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae species

In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae species

Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. Stapf, Poaceae, in rats

Influence of season, harvest time and drying on Java citronella (Cymbopogon winterianus Jowitt) volatile oil

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