Evaluation of the cardiovascular effects of vasicine, an alkaloid isolated from the leaves of Sida cordifolia L. (Malvaceae)

Silveira, Alethéia Lacerda da; Gomes, Michelle Acco; Filho, R.N. Silva; Santos, Márcio Roberto Viana dos; Medeiros, Isac A.; Barbosa-Filho, José Maria

doi:10.1590/s0102-695x2003000400012

Cited by 10 publications

(10 citation statements)

References 3 publications

(3 reference statements)

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“…These results, taken together with the study conducted by Silveira et al . (), suggest that these effects appear to be mainly due to the presence of vasicine, an alkaloid present in the leaves of S. cordifolia . Moreover chemical studies of the leaves of this plant revealed the presence of other alkaloids such as vasicinone and vasicinol.…”

Section: Discussionmentioning

confidence: 99%

“…Sida cordifolia L. (Malvaceae) is a native species of the Brazilian Northeast, popularly known as 'Malva branca'. It is used in folk medicine for its antirheumatic, antipyretic, antiasthmatic, nasal anticongestant activities (Silveira et al, 2003;Santos et al, 2005). In addition, it is reported to possess anticancer, diuretic, laxative, hypoglycemic, hepatoprotective (Kubavat and Asdaq, 2009), antiinflammatory and analgesic (Sutradhar et al, 2006Franzotti et al, 2000, hypotension and bradycardia activities (Santos et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Sida cordifolia Leaf Extract Reduces the Orofacial Nociceptive Response in Mice

Bonjardim

Silva

Oliveira

et al. 2011

Phytotherapy Research

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In this study, we describe the antinociceptive activity of the ethanol extract (EE), chloroform (CF) and methanol (MF) fractions obtained from Sida cordifolia, popularly known in Brazil as "malva branca" or "malva branca sedosa". Leaves of S. cordifolia were used to produce the crude ethanol extract and after CF and MF. Experiments were conducted on Swiss mice using the glutamate and formalin-induced orofacial nociception. In the formalin test, all doses of EE, CF and MF significantly reduced the orofacial nociception in the first (p < 0.001) and second phase (p < 0.001), which was also naloxone-sensitive. In the glutamate-induced nociception test, only CF and MF significantly reduced the orofacial nociceptive behavior with inhibition percentage values of 48.1% (100 mg/kg, CF), 56.1% (200 mg/kg, CF), 66.4% (400 mg/kg, CF), 48.2 (200 mg/kg, MF) and 60.1 (400 mg/kg, MF). Furthermore, treatment of the animals with EE, CF and MF was not able to promote motor activity changes. These data demonstrate that S. cordifolia has a pronounced antinociceptive activity on orofacial nociception. However, pharmacological and chemical studies are necessary in order to characterize the responsible mechanisms for this antinociceptive action and also to identify other bioactive compounds present in S. cordifolia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sida cordifolia Leaf Extract Reduces the Orofacial Nociceptive Response in Mice

Bonjardim

Silva

Oliveira

et al. 2011

Phytotherapy Research

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“…Phytochemical studies with this plant leaves have revealed the presence of quinolizidine alkaloids, such as vasicine, vasicinone and vasicinol (Ghosal et al, 1975). Pharmacological studies conducted in our laboratory identifi ed the cardiovascular activity of the alkaloid vasicine by Silveira et al (2003). In this work the antimicrobial activity of the essential oil of S. cordifolia against some bacteria and pathogenic fungi is reported.…”

Section: Introductionmentioning

confidence: 91%

“…In Brazil it is a common species found from north to south and is used as medicinal. In the Northeast region S. cordifolia is popularly known as "malva-branca" and is used in folk medicine for the treatment of rheumatisms, infl ammations, asthma and in nasal congestions (Silveira et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the essential oil of Sida cordifolia L.

Nunes¹,

Maia²,

Almeida³

et al. 2006

Rev. bras. farmacogn.

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RESUMO: "Atividade antimicrobiana do óleo essencial de Sida cordifolia L.". A análise da atividade antimicrobiana do óleo essencial de Sida cordifolia foi avaliada com quatro diferentes cepas de bactérias e nove de fungos. O óleo essencial foi testado "in natura" 100 % e diluído de 32 até 2 %. Os microrganismos, bactérias e fungos, foram semeados em ágar Muller-Hinton e Sabouraud dextrose, respectivamente. S. cordifolia mostrou atividade inibitória contra os microrganismos testados com efi cácia de 80 %. Quando testado contra Staphyllococus aureus, Staphyllococus epidermidis, Candida guilliermondii e Trichosporon inkin o óleo essencial mostrou um melhor desempenho.Unitermos: Sida cordifolia, Malvaceae, atividade antimicrobiana, óleo essencial. ABSTRACT:The analysis of the antimicrobial activity of the essential oil of Sida cordifolia was evaluated with four different strains of bacteria and nine fungi. The essential oil was tested "in natura" (100 %) and diluted from 32 until 2 %. The microorganisms, bacteria and fungi, were spread in agar Muller-Hinton and Sabouraud dextrose, respectively. S. cordifolia showed inhibitory activity against the microorganisms tested with effi cacy of 80 %. When tested against Staphylococcus aureus, Staphyllococus epidermidis, Candida guilliermondii and Trichosporon inkin the essential oil showed the best performance.

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“…Silveira et al [37] evaluated the cardiovascular effects of vasicine, an alkaloid isolated from the leaves of S. cordifolia L. The results of the study showed that vasicine produced hypotension and bradycardia which appeared to be due to the stimulation of cardiac muscarinic receptors (directly and/or indirectly), and by a decrease of the peripheral resistances.…”

Section: Hypotensive and Bradycardia Effectsmentioning

confidence: 99%

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

Khurana

Sharma

Patil

et al. 2016

Asian J Pharm Clin Res

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Plants have been considered to be useful as a medicine for treating different ailments and improving health conditions, since ancient times. The plants as herbal drugs lay down an important foundation of different, well recognized, ancient, and traditional healthcare systems in India as well as other parts of the world. In India, plants constitute an important and indispensable role in different ancient healthcare systems such as Ayurveda, Siddha, Unani, Naturopathy, and Homeopathy. In Ayurveda system of medicine, one of the Rasayana plants having a great medicinal importance is Sida cordifolia belonging to the family Malvaceae. It is an annual undershrub found throughout the tropical and subtropical regions of India. It has been used since ancient times for various ailments in Ayurveda system of medicine. It has numerous folklore uses in different pathological conditions. The plant also reported to possess a number of important pharmacological activities. The present review focused on all these folklore use of this herb along with its reported pharmacological activities.

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Evaluation of the cardiovascular effects of vasicine, an alkaloid isolated from the leaves of Sida cordifolia L. (Malvaceae)

Cited by 10 publications

References 3 publications

Sida cordifolia Leaf Extract Reduces the Orofacial Nociceptive Response in Mice

Sida cordifolia Leaf Extract Reduces the Orofacial Nociceptive Response in Mice

Antimicrobial activity of the essential oil of Sida cordifolia L.

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

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