Uric Acid and Tissue Repair

Nery, Rodrigo Araldi; Kahlow, Bárbara Stadler; Skare, Thelma Larocca; Tabushi, Fernando Issamu; Castro, Adham do Amaral e

doi:10.1590/s0102-6720201500040018

Cited by 28 publications

(22 citation statements)

References 30 publications

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“…Ridi and Tallima [ 42 ] in their review pointed out that uric acid is the major antioxidant molecule in the blood, which is essential to counteract oxidative damage due to infections and toxicosis. Uric acid has also been reported able to stimulate the immune responses of animals against the invasion of pathogenic microorganisms [ 43 ]. Overall, supplementation of commercial broiler feeds with multistrain probiotics seemed beneficial to reduce the invasion of infectious agents [ 44 ], resulting in less production of uric acids (as part of defense mechanisms against infections).…”

Section: Discussionmentioning

confidence: 99%

The effect of supplementation of multistrain probiotic preparation in combination with vitamins and minerals to the basal diet on the growth performance, carcass traits, and physiological response of broilers

et al. 2018

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Aim:The aim of the present study was to investigate the effect of supplementation of multistrain probiotic preparation in combination with vitamins and minerals to the broiler chicken diets on their growth performance, hematological parameters, and carcass traits.Materials and Methods:Two hundred and eighty-eight Lohmann 1-day-old broiler chicks were randomly allocated to four groups, i.e., control (without additional supplementation) and three experimental treatments where basal diet was enriched by 0.1%, 0.5%, or 1% of multistrain probiotic preparation in combination with vitamins and minerals, respectively. Blood sampling was conducted on day 28, while the selected organs and eviscerated carcasses were collected on day 42.Results:Dietary supplementation did not affect (p>0.05) the final body weight, feed intake, and feed conversion ratio of broilers. Supplementation by 0.1% and 0.5% of multistrain probiotic preparation in combination with vitamins and minerals reduced (p≤0.05) heart relative weight of broilers. Dietary supplementation tended (p=0.07) to increase the relative weight of ileum and pancreas of broilers. Supplemented birds had lower (p≤0.05) numbers of leukocytes and eosinophils compared to unsupplemented birds. There were tendencies that supplementation of multistrain probiotics in combination with vitamins and minerals resulted in lower (p=0.07) counts of lymphocytes and heterophils when compared with no supplementation. Supplementation by 0.5% of multistrain probiotics in combination with vitamins and minerals resulted in lower (p≤0.05) serum concentration of uric acid when compared with control. There was no significant effect of dietary supplementation on carcass traits, pH, and drip loss of broiler breast muscles.Conclusion:Dietary supplementation of commercial broiler feeds with 0.5% of multistrain probiotic preparation in combination with vitamins and minerals was potential to improve digestive functions and physiological status of broiler chickens.

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Section: Discussionmentioning

confidence: 99%

The effect of supplementation of multistrain probiotic preparation in combination with vitamins and minerals to the basal diet on the growth performance, carcass traits, and physiological response of broilers

et al. 2018

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“…This and other reports challenged the view stating that uric acid elicits cardiovascular and kidney diseases via impairing endothelial integrity and function [13], [14], [15]. Indeed, uric acid may exert fundamental roles in tissue healing via initiating the inflammatory process that is necessary for tissue repair, scavenging oxygen free radicals, and mobilizing progenitor endothelial cells [15].…”

Section: Endothelial Functionmentioning

confidence: 98%

Physiological functions and pathogenic potential of uric acid: A review

Ridi

Tallima

2017

Journal of Advanced Research

327

252

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“…It can be divided into three phases: 1 st or exudative inflammation; 2 nd or proliferative/ fibroblastic (granulation tissue with deposition of extracellular matrix); 3 rd or remodeling/maturation [1][2][3][4][5][6] . The knowledge of each of these stages is important to guide appropriate adjuvant therapy to improve biological reaction 6 .…”

Section: Introductionmentioning

confidence: 99%

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

et al. 2016

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METHODS:Fifty four rats were used, distributed into three groups randomly: aroeira, babassu and control, which were divided into three subgroups (six animals) according to the time of the deaths (7, 14, 21 days). All underwent the same surgical procedure, cecotomy and cecorrhaphy. The animals in group aroeira and babassu received daily dose of 100 mg/kg of hydroalcoholic extract and 50 mg/kg of aquous extract respectively, by gavage. The control group received only saline solution. The parameters evaluated were: macroscopic changes, ,resistance test to air insufflations and histological changes. RESULTS:All animals showed good healing without infection. All groups presented adhesions between cecum and neighboring organs.The resistance test insufflating of atmospheric air showed progressive increase of pressure according to the days in the aroeira group, and decrease in babassu group, without significant difference. Microscopy showed significant difference in the polymorphonuclear, hyperemia, angiogenesis, fibroblast proliferation and collagen histological variables in the 14 th day. CONCLUSION:Hydroalcoholic extract of aroeira and the aqueous extract of babassu favored the healing process in cecorrhaphy in rats.

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Uric Acid and Tissue Repair

Cited by 28 publications

References 30 publications

The effect of supplementation of multistrain probiotic preparation in combination with vitamins and minerals to the basal diet on the growth performance, carcass traits, and physiological response of broilers

The effect of supplementation of multistrain probiotic preparation in combination with vitamins and minerals to the basal diet on the growth performance, carcass traits, and physiological response of broilers

Physiological functions and pathogenic potential of uric acid: A review

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

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