Comparison of Hepatic Profile in Pre and Postoperative of Bariatric Surgery: Private vs Public Network

Nascimento, Taianne Machado; Alves-Júnior, Antônio; Nunes, Marco Antônio Prado; Freitas, Tiago Rodrigo Pereira de; Silva, Marco Antonio Fontes Sarmento da; Alves, Maria Rosa Melo

doi:10.1590/s0102-6720201500040014

Cited by 10 publications

(4 citation statements)

References 19 publications

(23 reference statements)

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“…Two recent meta-analyses have reported that RYGB had a positive effect on NAFLD after short- to mid-term follow-up time of 1–60 months, with improvement or resolution of histological steatosis and steatohepatitis in the majority of patients, as well as resolution of fibrosis in 28–51% [ 12 , 13 ]. Importantly, studies assessing resolution of liver fibrosis after RYGB with NFS and/or FIB-4 have found improvement in agreement with studies using biopsies [ 26 , 27 , 28 , 29 ]. The proportion of patients with a low postoperative fibrosis score was similar in our population to that in studies with shorter follow-up times [ 11 , 12 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Discussionsupporting

confidence: 71%

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

Sandvik

Aasarød

Johnsen

et al. 2022

JCM

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Severe obesity is a strong risk factor for non-alcoholic fatty liver disease (NAFLD). Roux-en-Y gastric bypass (RYGB) surgery effectively induces weight loss, but few studies have described the long-term effects of RYGB on NAFLD-related fibrosis. Data from 220 patients with severe obesity operated by RYGB in Central Norway were analysed. Variables incorporated in NAFLD Fibrosis Score (NFS), Fibrosis-4 (FIB-4) index and anthropometric data were collected before surgery and a mean of 11.6 years postoperatively. FIB-4 > 1.3 or NFS > 0.675 were used as cut-off values for advanced fibrosis. Proportions with advanced fibrosis decreased from 24% to 14% assessed by FIB-4 and from 8.6% to 2.3% using NFS, with resolution rates of advanced fibrosis of 42% and 73%, respectively. The shift towards lower fibrosis categories was significant (NFS p < 0.0001; FIB-4 p = 0.002). NFS decreased from −1.32 (IQR −2.33–−0.39) to −1.71 (IQR −2.49–−0.95, p < 0.001) 11.6 years after surgery, whereas FIB-4 did not change: 0.81 (IQR 0.59–1.25) to 0.89 (IQR 0.69–1.16, p = 0.556). There were weak correlations between change in fibrosis scores and weight loss. In conclusion, the majority of patients with advanced fibrosis at baseline had improvement after 11.6 years. Factors associated with reduction in fibrosis were not identified.

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Section: Discussionsupporting

confidence: 71%

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

Sandvik

Aasarød

Johnsen

et al. 2022

JCM

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“…Resection appears today as the main approach for treatment of HCC, especially in patients with good liver function. This mainly occurs because of the restrictive criteria and the inadequate supply of grafts for transplantation in the world 1 , 11 , 13 , 16 , 19 .…”

Section: Discussionmentioning

confidence: 99%

Influence of Hepatocellular Carcinoma Etiology in the Survival After Resection

Lopes

Coelho

Krüger

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and its incidence is increasing around the world in the last decades, making it the third cause of death by cancer in the world. Hepatic resection is one of the most effective treatments for HCC with five-year survival rates from 50-70%, especially for patients with a single nodule and preserved liver function. Some studies have shown a worse prognosis for HCC patients whose etiology is viral. That brings us to the question about the existence of a difference between the various causes of HCC and its prognosis. Aim: To compare the prognosis (overall and disease-free survival at five years) of patients undergoing hepatectomy for the treatment of HCC with respect to various causes of liver disease. Method: Was performed a review of medical records of patients undergoing hepatectomy between 2000 and 2014 for the treatment of HCC. They were divided into groups according to the cause of liver disease, followed by overall and disease-free survival analysis for comparison. Results:There was no statistically significant difference in the outcomes of the groups of patients divided according to the etiology of HCC. Overall and disease-free survival at five years of the patients in this sample were 49.9% and 40.7%, respectively. Conclusion: From the data of this sample, was verified that there was no prognostic differences among the groups of HCC patients of the various etiologies.

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“…Liver fibrosis scores improved after surgery in the present study. Nascimento et al [ 23 ] also found an improved NAFLD fibrosis score 12 months after bariatric surgery. Several studies have shown good validity for APRI and FIB-4 scores in detecting liver fibrosis [ 18 24 ].…”

Section: Discussionmentioning

confidence: 96%

Short-term outcome of bariatric surgery on nonalcoholic fatty liver disease: a Korean perspective

Kim

Seo

et al. 2022

Ann Surg Treat Res

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Purpose Obesity is associated with nonalcoholic fatty liver disease, one of the most common causes of chronic liver disease. We aimed to demonstrate the effectiveness of bariatric surgery for hepatic steatosis and fibrosis in Korean patients. Methods A total of 32 consecutive patients were enrolled in this study. Hepatic steatosis and liver fibrosis were assessed before surgery and 6 months after surgery using transient elastography and serologic panels. Results Thirteen patients (40.6%) were male and 19 (59.4%) were female, with a mean age of 39.3 ± 11.3 years. The body mass index was significant at the 6th month: 39.1 ± 6.7 and 30.3 ± 4.7 kg/m 2 (P < 0.001), respectively. The mean preoperative controlled attenuation parameter and liver stiffness measurement values were 325.4 ± 55.9 dB/m and 7.4 ± 4.8 kPa, respectively, before surgery, and they decreased to 267.1 ± 45.1 dB/m and 5.3 ± 2.3 kPa, respectively, 6 months postoperatively (P < 0.001, respectively). Conclusion These results suggest that bariatric surgery is associated with a significant improvement in liver steatosis and fibrosis. Bariatric surgery has a beneficial effect on nonalcoholic fatty liver disease in patients with morbid obesity in Korea.

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Comparison of Hepatic Profile in Pre and Postoperative of Bariatric Surgery: Private vs Public Network

Cited by 10 publications

References 19 publications

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores—An 11.6-Year Follow-Up Study

Influence of Hepatocellular Carcinoma Etiology in the Survival After Resection

Short-term outcome of bariatric surgery on nonalcoholic fatty liver disease: a Korean perspective

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