Blood count and C-reactive protein evolution in gastric cancer patients with total gastrectomy surgery

Ja, Csendes; ChA, Muñoz; Burgos, L.

doi:10.1590/s0102-67202014000400002

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Прогностическим маркером инфекционных осложнений в послеоперационном периоде является нарастание концентрации С-реактивного белка (СРБ) в плазме крови, определение уровня которого служит дешевым, простым и доступным в рутинной практике лабораторным тестом. В послеоперационном периоде во всех случаях резкое увеличение концентрации СРБ отмечается в течение первых шести часов по-сле хирургического вмешательства, достигая пика ко 2-3-му ПОД [51,52]. При развитии инфекционного процесса отмечается более высокий уровень СРБ и его последующее нарастание по сравнению с неосложненным послеоперационным периодом [51,52].…”

Section: с-реактивный белок в диагностике осложненийunclassified

“…В послеоперационном периоде во всех случаях резкое увеличение концентрации СРБ отмечается в течение первых шести часов по-сле хирургического вмешательства, достигая пика ко 2-3-му ПОД [51,52]. При развитии инфекционного процесса отмечается более высокий уровень СРБ и его последующее нарастание по сравнению с неосложненным послеоперационным периодом [51,52]. Нарастание концентрации СРБ в динамике позволяет с высокой степенью уверенности выявлять инфекционные осложнения до развития клинических проявлений и менять тактику лечения.…”

Section: с-реактивный белок в диагностике осложненийunclassified

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Enhanced Recovery in Surgery for Gastric Cancer

Ilina

Ruchkin

Козырин

et al. 2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. A summarising review of national and international practices in enhanced recovery after surgery (ERAS) for gastric cancer.Key points. Although ERAS is a routine protocol in colorectal surgery, little agreement exists on its eﬀectiveness and safety in upper gastrointestinal surgery, particularly, for gastric cancer (GC). General recommendations are being widely followed in clinical practice, whilst the adherence to GC-speciﬁc measures is still limited. The review highlights the speciﬁc measures of perioperative nutrition, surgical approach, early postoperative diet, phase-out of routine nasogastric or nasojejunal tubes, audit of results. The GC-speciﬁc protocols include the early detection of postoperative complications, especially the oesophagojejunal anastomosis leakage, to facilitate the ERAS safety and early oral nutrition.Conclusion. Current evidence suggests a strong association of ERAS with improved outcomes and quality of life in the early postoperative period. The long-term impact of ERAS remains understudied but is expected to reduce complications and their severity in oncological surgery.

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Section: с-реактивный белок в диагностике осложненийunclassified

Enhanced Recovery in Surgery for Gastric Cancer

Ilina

Ruchkin

Козырин

et al. 2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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C-reactive protein is a predictor of severe infective complications following gastrectomy—a retrospective analysis

McOwan¹,

Johnson²,

Ward³

et al. 2023

J Gastrointest Oncol

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Background: Post-operative complications are the main contributing factor to increased length of stay, increased cost of care and short-term mortality experienced by patients following gastrectomy. The purpose of this study was to determine the diagnostic accuracy of C-reactive protein (CRP) in predicting complications following gastrectomy. This may assist clinicians to make better informed clinical decisions in the post-operative period.Methods: A retrospective analysis of a prospectively maintained database was performed. Sixty patients who underwent gastrectomy for gastric cancer were included. Demographic information, operative data and post-operative details such as complications, unplanned intensive care unit (ICU) admission and readmission to hospital were analysed. Complications were further analysed based on whether they were either infective or non-infective in nature. Receiver operator characteristic (ROC) analysis was performed to examine the association between CRP and post-operative morbidity. Optimum cut-offs were determined using the Youden's index.Results: From the second post-operative day (POD), CRP levels were able to predict subsequent severe infective (SI) complications following gastrectomy [area under the curve (AUC): 0.789, 95% CI : 0.636-0.941]. An optimum cut-off of 180 mg/L resulted in a sensitivity of 87.50%. The negative predictive value (NPV) at this point was 96.30%.Conclusions: CRP is a strong negative predicter of SI complications following gastrectomy. This suggests early CRP values may be useful in prompting early investigation or facilitating safer, earlier discharge from hospital. Health services may benefit by determining similar cut-offs based on their own unique patient populations.

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Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery

Parsak

Topal

Altiok

et al. 2022

Preprint

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Purpose: This study investigated the risk factors associated with mediastinal lymph node metastases due to proximal gastric cancer. Methods: The study included patients who had surgical resection and Transcrural lymphadenectomy for proximal gastric tumors between January 2012 and January 2020. The patients were divided into Group1 (negative) and Group2 (positive) according to the positivity of mediastinal lymph nodes. These groups were compared for clinical variables. The diagnostic value of composite immunonutritional and inflammatory indices in predicting lymph node positivity was examined. Results: There were 88 patients in our study. Group1 included 54 and Group2 included 34 patients.Among the laboratory parameters, only CRP was higher in Group 2 (4.58 vs. 10.7, p= 0.044). The rate of postoperative respiratory complications (5.6% vs. 29.4%, p:0.002) was higher in Group2 The tumor size (25.3 vs. 33 mm, p:0.0001), was higher in Group2. Tumors were more advanced in Group2 (p<0.001). Among the composite indices, only the neutrophil-to-lymphocyte ratio had a diagnostic value, with a sensitivity of 67.65% and a specificity of 55.56% at a cut-off point of >2.19. According to the multivariate analysis, a tumor size of >3 cm, a CRP value of >7, and tumor localization were independent risk factors. Conlusion: Our study found that mediastinal lymph node positivity was associated with elevated CRP and that these patients had more advanced tumors and poor histopathological characteristics. Knowing the relationship between clinicopathological characteristics and mediastinal lymph node positivity in proximal gastric tumors can be useful in determining the surgical strategy for EGJ tumors.

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Blood count and C-reactive protein evolution in gastric cancer patients with total gastrectomy surgery

Cited by 6 publications

References 9 publications

Enhanced Recovery in Surgery for Gastric Cancer

Enhanced Recovery in Surgery for Gastric Cancer

C-reactive protein is a predictor of severe infective complications following gastrectomy—a retrospective analysis

Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery

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