Combined liver-kidney transplantation: experience at a brazilian university hospital

Veras, Francisca Jovita de Oliveira; Coelho, Gustavo; Feitosa-Neto, Bartolomeu Alves; Cerqueira, João Batista Gadelha de; Garcia, Raquel Fernandes; Garcia, José Huygens Parente

doi:10.1590/s0102-67202014000100013

Cited by 6 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This appears to be surprising since the overall results and outcomes of LKTX procedures are acceptable but inferior to those of patients who undergo single-organ transplant procedures. 38,39 Thus, the fatigue scores found in the present study do not mirror the physical challenge that is represented by a double-organ transplant. However, almost 20% of patients from the OLT group stated that their health status had improved, whereas there were no patients from the LKTX group who marked a response of healthier than the year before.…”

Section: Discussioncontrasting

confidence: 63%

Untitled

Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: To date, fatigue is still poorly understood in recipients of orthotopic liver transplant and simultaneous/sequential liver and kidney transplant procedures. The present study examined the appearance of fatigue in patients who received orthotopic liver and sequential liver and kidney transplant procedures compared with the general population and the influence of various clinical and socioeconomic factors on fatigue levels. Materials and Methods: The Multidimensional Fatigue Inventory survey was sent to all patients with a history of orthotopic liver and simultaneous/sequential liver and kidney transplant. The results were compared to data from a reference population. Results: Our survey included 276 eligible patients: 256 recipients (92.7%) of orthotopic liver transplant and 20 recipients (7.3%) of simultaneous/sequential liver and kidney transplant. Significantly lower fatigue scores were found in the general population compared with both transplant groups (P < .001). There were also no significant differences between the transplant groups. Among the clinical and socioeconomic factors, history of hepatocellular carcinoma, chronic kidney disease, age, family status, and education had a significant impact on fatigue levels. Conclusions: This is the first study to compare fatigue in recipients of orthotopic liver and simultaneous/-sequential liver and kidney transplant. We found that fatigue is an important but still poorly understood outcome after transplant.

show abstract

Section: Discussioncontrasting

confidence: 63%

Untitled

Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

show abstract

“…Cases of dual (liver-kidney) transplants increased during the MELD era and there was not much difference in short-term survival rate between this procedure and liver transplant alone. Veras et al 25 came up with a similar finding but also noted a lower survival rate in the 3 rd and 5 th years after a dual transplant.…”

Section: Discussionmentioning

confidence: 58%

“…Veras et al 25 came up with a similar finding but also noted a lower survival rate in the 3 rd and 5 th years after a dual transplant. …”

Section: Discussionmentioning

confidence: 61%

See 1 more Smart Citation

The Impact of the Meld Score on Liver Transplant Allocation and Results: An Integrative Review

Moraes

Oliveira

Fonseca-Neto

2017

ABCD, arq. bras. cir. dig.

View full text Add to dashboard Cite

Introduction: Liver transplantation is intended to increase the survival of patients with chronic liver disease in terminal phase, as well as improved quality of life. Since the first transplant until today many changes have occurred in the organ allocation system. Objective:To review the literature on the Model for End-stage Liver Disease (MELD) and analyze its correlation with survival after liver transplantation. Method:An integrative literature review in Lilacs, SciELO, and Pubmed in October 2015, was realized. Were included eight studies related to the MELD score and its impact on liver transplant. Results:There was predominance of transplants in male between 45-55 y. The main indications were hepatitis C, hepatocellular carcinoma and alcoholic cirrhosis. The most important factors post-surgery were related to the MELD score, the recipient age, expanded donor criteria and hemotransfusion. Conclusion:The MELD system reduced the death rate in patients waiting for a liver transplant. However, this score by itself is not a good predictor of survival after liver transplantation.

show abstract

“…The challenge in adopting an extra score is seeking criteria that reduce the chance of being prioritizing patients with advanced HCC, with high risk of recurrence, instead of patients with higher MELD score 6 , 22 , 24 , 29 .…”

Section: Introductionmentioning

confidence: 99%

Liver Transplantation for Carcinoma Hepatocellular in São Paulo: 414 Cases by the Milan/Brazil Criteria

Sá

Vicentine

Netto

et al. 2016

ABCD, arq. bras. cir. dig.

View full text Add to dashboard Cite

Background: The criterion of Milan (CM) has been used as standard for indication of liver transplantation (LTx) for hepatocellular carcinoma (HCC) worldwide for nearly 20 years. Several centers have adopted criteria expanded in order to increase the number of patients eligible to liver transplantation, while maintaining good survival rates. In Brazil, since 2006, the criterion of Milan/Brazil (CMB), which disregards nodules <2 cm, is adopted, including patients with a higher number of small nodules. Aim: To evaluate the outcome of liver transplantation within the CMB. Methods: The medical records of patients with HCC undergoing liver transplantation in relation to recurrence and survival by comparing CM and CMB, were analyzed. Results: 414 LTx for HCC, the survival at 1 and 5 years was 84.1 and 72.7%. Of these, 7% reached the CMB through downstaging, with survival at 1 and 5 years of 93.1 and 71.9%. The CMB patient group that exceeded the CM (8.6%) had a survival rate of 58.1% at five years. There was no statistical difference in survival between the groups CM, CMB and downstaging. Vascular invasion (p<0.001), higher nodule size (p=0.001) and number of nodules >2 cm (p=0.028) were associated with relapse. The age (p=0.001), female (p<0.001), real MELD (p<0.001), vascular invasion (p=0.045) and number of nodes >2 cm (p<0.014) were associated with worse survival. Conclusions: CMB increased by 8.6% indications of liver transplantation, and showed survival rates similar to CM.

show abstract

Combined liver-kidney transplantation: experience at a brazilian university hospital

Cited by 6 publications

References 10 publications

Untitled

Untitled

The Impact of the Meld Score on Liver Transplant Allocation and Results: An Integrative Review

Liver Transplantation for Carcinoma Hepatocellular in São Paulo: 414 Cases by the Milan/Brazil Criteria

Contact Info

Product

Resources

About