Correlação do tipo de biópsia e sua validade diagnóstica nos tumores músculo-esqueléticos em distintas topografias

Siqueira, Karina Levy; Viola, Dan Carai Maia; Filho, Reynaldo Jesus Garcia; Gracitelli, Guilherme Conforto

doi:10.1590/s0102-36162008000100002

Cited by 7 publications

(6 citation statements)

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, the gold standard is still percutaneous biopsy with trephine or "core" biopsy for histological evaluation of musculoskeletal lesions, obtaining high accuracy rates, such as 73.9%, ( 2 ) to 96%, ( 20 ) as observed in our study received similar success rate with 92.19%.…”

Section: Discussionsupporting

confidence: 76%

Effectiveness of histology and cytology on musculoskeletal tumor diagnosis

Lima¹,

Oliveira²,

Ferreira³

et al. 2014

Acta ortop. bras.

View full text Add to dashboard Cite

OBJECTIVE: To compare cytology and histology on the diagnosis of musculoskeletal neoplasms. METHOD: Fifty eight cases available to evaluation were analyzed both by cytology and histology. The results of the biopsies studied by histology and cytology were compared to the results obtained on the surgical specimen or immunohistochemistry. We determined the percentage of correct results, sensitivity, specificity, positive and negative predictive values and accuracy of each method. RESULTS: Twelve per cent of biopsies were inconclusive by cytology. The percentage of correct diagnosis was 70.7% and 81% (p=.179), the ability to differentiate benign lesions from malignant ones was 84.5% and 93.1% (p=0.18) respectively, for cytology and histology. Cytology showed sensitivity of 87.8%, specificity of 76.5%, positive predictive value of 90%, negative predictive value of 72% and accuracy 84.5%. Histology showed sensitivity of 90.2%, specificity of 100%, positive predictive value of 100%, negative predictive value of 81% and accuracy of 93.1%. The Youden index for cytology was 64.3% and for histology it was 90.2%. CONCLUSION: Despite promising, cytology obtained by thin needle aspiration is less accurate and reliable than the histological evaluation on musculoskeletal tumors diagnosis. Level of Evidence II, Diagnostic Studies.

show abstract

Section: Discussionsupporting

confidence: 76%

Effectiveness of histology and cytology on musculoskeletal tumor diagnosis

Lima¹,

Oliveira²,

Ferreira³

et al. 2014

Acta ortop. bras.

View full text Add to dashboard Cite

show abstract

“…In this regard, the biopsy is pointed out as a fundamental step, being essential for the definitive diagnosis and to identify the histological pattern of tumor 1 3 Biopsy must offer adequate and representative tissue samples for accurate diagnosis, without however manipulate excessively the lesion in order to avoid modifying the tumor relationship between anatomical compartments and contamination of surrounding tissues with tumor cells 2 …”

Section: Introductionmentioning

confidence: 99%

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

et al. 2014

View full text Add to dashboard Cite

To identify, through a systematic literature review, the characteristics of neoplasm seeding in biopsy performed on the musculoskeletal system. We performed a search on PubMed, MEDLINE, LILACS and SciELO from August to October 2010. We included articles that addressed the neoplasm seeding in biopsy performed on the musculoskeletal system. The search was limited to English, Spanish and Portuguese as publication languages, but it was not limited by year of publication. We retrieved 2858 articles, but only seven were selected based on inclusion and exclusion criteria. Other four papers were found in the references of selected articles, totalizing 11 articles that were used to perform this systematic review. Issues may be raised in the literature: age and gender don't seem to influence the occurrence of neoplasm seeding; without resection of the biopsy tract, the possibility of local recurrence is very real; the influence of the type of tumor in the occurrence of neoplasm seeding is uncertain; it is impossible to conclude whether the closed biopsy technique has a lower chance of neoplasm seeding; it is likely that adjuvant chemotherapy has a protective effect against neoplasm seeding; an unfavorable prognosis is expected according to neoplasm seeding results.

show abstract

“…Dealing with these tumors requires integration of clinical, laboratory, radiographic and histological characteristics in order to achieve a precise diagnosis and management leading to successful treatment. In this respect, biopsy can be highlighted as a fundamental step in dealing with tumors of the musculoskeletal system, and it is indispensable for achieving a definitive diagnosis and for identifying the histological pattern of the tumor 4 , 6 , 7 . Biopsies should provide sufficient representative tissue sample for a precise diagnosis, but without excessively manipulating the lesion, so as to avoid modifying the tumor's relationship with the anatomical compartments and contaminating the neighboring tissues with tumor cells (7) .…”

Section: Introductionmentioning

confidence: 99%

Tumor Contamination in the Biopsy Path of Primary Malignant Bone Tumors

Oliveira

Lima

Mello

2012

Revista Brasileira de Ortopedia (English Edition)

View full text Add to dashboard Cite

Objective: To study factors possibly associated with tumor contamination in the biopsy path of primary malignant bone tumors. Method: Thirty-five patients who underwent surgical treatment with diagnoses of osteosarcoma, Ewing's tumor and chondrosarcoma were studied retrospectively. The sample was analyzed to characterize the biopsy technique used, histological type of the tumor, neoadjuvant chemotherapy used, local recurrences and tumor contamination in the biopsy path. Results: Among the 35 patients studied, four cases of contamination occurred (11.43%): one from osteosarcoma, two from Ewing's tumor and one from chondrosarcoma. There was no association between the type of tumor and presence of tumor contamination in the biopsy path (p = 0.65). There was also no association between the presence of tumor contamination and the biopsy technique (p = 0.06). On the other hand, there were associations between the presence of tumor contamination and local recurrence (p = 0.01) and between tumor contamination and absence of neoadjuvant chemotherapy (p = 0.02). Conclusion: Tumor contamination in the biopsy path of primary malignant bone tumors was associated with local recurrence. On the other hand, the histological type of the tumor and the type of biopsy did not have an influence on tumor contamination. Neoadjuvant chemotherapy had a protective effect against this complication. Despite these findings, tumor contamination is a complication that should always be taken into consideration, and removal of the biopsy path is recommended in tumor resection surgery.

show abstract

Correlação do tipo de biópsia e sua validade diagnóstica nos tumores músculo-esqueléticos em distintas topografias

Cited by 7 publications

References 9 publications

Effectiveness of histology and cytology on musculoskeletal tumor diagnosis

Effectiveness of histology and cytology on musculoskeletal tumor diagnosis

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

Tumor Contamination in the Biopsy Path of Primary Malignant Bone Tumors

Contact Info

Product

Resources

About