Avaliação de parâmetros histológicos na pneumonia intersticial usual (fibrose pulmonar idiopática)

Ferreira, Rimarcs Gomes; Coletta, Ester Nei Aparecida Martins; Filho, O G Silva

doi:10.1590/s0102-35862000000600002

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…A concordância entre os patologistas na análise independente das lâminas foi quantificada usando-se o coeficiente de kappa (estes dados foram anteriormente publicados) (18) Os achados histológicos em relação à sobrevida foram avaliados inicialmente por regressão de Cox para os achados individuais. Apenas os escores de focos fibroblásticos e de espessamento miointimal correlacionaram-se significativamente (p < 0,05) com a sobrevida.…”

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Achados histológicos e sobrevida na fibrose pulmonar idiopática

Coletta¹,

Pereira

Ferreira

et al. 2003

J. Pneumologia

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Background: Idiopathic pulmonary fibrosis was recently redefined as usual interstitial pneumonia of unknown etiology. Consequently, the prognostic value of histological findings needs to be reassessed. Objective: To correlate clinical, functional and histological findings with survival in patients with idiopathic pulmonary fibrosis. Method: Patients (n = 51; mean age: 66 ± 8 years; gender: 21 females/30 males) were evaluated. Of the 51, 26 were smokers or ex-smokers. Duration of symptoms, forced vital capacity and smoking habits were recorded. All patients presented usual interstitial pneumonia verified through histology. Degree of honeycombing, established fibrosis, desquamation, cellularity, myointimal thickening of blood vessels and number of fibroblastic foci were graded according to the semiquantitative method. Results: Median duration of symptoms was 12 months and initial forced vital capacity was 72 ± 21%. Cox multivariate analysis revealed that survival correlated inversely and significantly (p < 0.05) with duration of symptoms and fibroblastic foci score, as well as with myointimal thickening of blood vessels. Limited numbers of fibroblastic foci, as well as myointimal thickening involving less than 50% of blood vessels, were predictive of greater survival. No correlation with survival was found for gender, age, forced vital capacity, inflammation or degree of cellularity. Conclusion: Semiquantitative analysis of lung biopsies yields relevant prognostic information regarding patients with usual interstitial pneumonia.

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Achados histológicos e sobrevida na fibrose pulmonar idiopática

Coletta¹,

Pereira

Ferreira

et al. 2003

J. Pneumologia

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“…Other research centers in Brazil have published their experience using the same score, confirming previously published findings. (18,19) For the use of this score, three main criteria for quantification were established: a) exudative/inflammatory changes; b) fibrotic/reparative changes; and c) airway changes. These alterations were quantified using a scale ranging from 0 to 5 for criteria a and b, together with a scale ranging from 0 to 2 for criterion c.…”

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confidence: 99%

Análise semiquantitativa de biópsias cirúrgicas de diferentes lobos pulmonares de pacientes com pneumonia intersticial usual/fibrose pulmonar idiopática

Gonçalves¹,

Leão

Ferreira

et al. 2009

J. bras. pneumol.

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Objective: To evaluate the differences between surgical biopsies of distinct lung lobes in terms of the histopathological features of usual interstitial pneumonia, using a semiquantitative score. Methods: We selected all of the patients diagnosed with idiopathic pulmonary fibrosis and submitted to surgical biopsy in two distinct lobes between 1995 and 2005 at the Hospital São Paulo and other hospitals operated by the Federal University of São Paulo. In the histological evaluation of the specimens, we used a semiquantitative method based on previous studies, assigning a score to each of the biopsied sites. Results: In this sample of patients, we found no statistically significant differences that would alter the stage of the disease, based on the score used. This finding was independent of the biopsy site (middle lobe or lingular segment). Conclusions: No significant histological differences were found between the lung lobes studied. The definitive histological diagnosis of usual interstitial pneumonia did not alter the stage of the disease.Keywords: Lung diseases, interstitial; Pulmonary fibrosis; Thoracic surgery; Pathology; Thoracic surgery, video-assisted. ResumoObjetivo: Avaliar as diferenças histológicas da pneumonia intersticial usual entre biópsias cirúrgicas de lobos pulmonares distintos, utilizando um escore semiquantitativo. Métodos: Foram selecionados todos os pacientes com o diagnóstico de fibrose pulmonar idiopática e submetidos à biópsia cirúrgica em dois lobos distintos no Hospital São Paulo e em hospitais afiliados da Universidade Federal de São Paulo, no período entre 1995 e 2005. Foi utilizado um método semiquantitativo na avaliação histológica dos espécimes, com base em estudos prévios, aplicando-se um escore para cada local submetido à biópsia. Resultados: Nenhuma diferença estatisticamente significante foi encontrada nesta amostra de pacientes que viesse alterar o estágio da doença, com base no escore utilizado. Este achado foi independente do local da biópsia (lobo médio ou segmento lingular). Conclusões: Não foram observadas diferenças histológicas significantes entre os lobos pulmonares estudados. O diagnóstico histológico definitivo de pneumonia intersticial usual não alterou o estágio da doença.

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Relationship between the Phase Angle and Volume of Tumours in Patients with Lung Cancer

Castanho¹,

Lopes²,

Koury

et al. 2012

Ann Nutr Metab

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Background/Aims: The phase angle (PA) obtained by bioelectrical impedance has been used as a predictor of nutritional status in cancer. This study aimed to verify the association between the PA and tumour volume in non-small cell lung cancer (NSCLC) patients. Methods: Volumetric determination of the tumour mass was performed using a computerised image analysis system incorporated in helical tomography. Lesion segmentation was performed by a semi-automatic process using a region growth algorithm with voxel aggregation. The PA was measured by bioelectrical impedance. Results: A total of 30 male patients with a mean age of 65.6 years were evaluated. The mean values observed for body mass index, PA and tumour volume were 22.5 ± 4.19, 5.66 ± 0.9° and 163.2 ± 207.5 ml, respectively. The tumour volumes were negatively correlated with the PA (r = –0.55; p < 0.001) and positively correlated with the ratio between the extracellular mass and the body cell mass (ECM/BCM) (r = 0.59; p < 0.001). In multivariate analysis, independent predictors for both PA and ECM/BCM were tumour volume and Karnofsky performance status score. Conclusions: In NSCLC, the PA is closely associated with tumour volume, which may be important in early nutritional intervention.

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Avaliação de parâmetros histológicos na pneumonia intersticial usual (fibrose pulmonar idiopática)

Cited by 4 publications

References 13 publications

Achados histológicos e sobrevida na fibrose pulmonar idiopática

Achados histológicos e sobrevida na fibrose pulmonar idiopática

Análise semiquantitativa de biópsias cirúrgicas de diferentes lobos pulmonares de pacientes com pneumonia intersticial usual/fibrose pulmonar idiopática

Relationship between the Phase Angle and Volume of Tumours in Patients with Lung Cancer

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