Tipos nomenclaturais do herbário da Universidade Estadual de Campinas (UEC): Leguminosae

Vasconcellos, Marina Bragatto

doi:10.1590/s0102-33061987000200005

Cited by 1 publication

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“…4 Existem alguns estudos relacionados à identificação de compostos químicos desta espécie e sua atividade anticancerígena. [7][8][9][10][11][12][13][14] É reportado na literatura o isolamento e identificação de substâncias derivadas do floroglucinol poliprenilados em extratos hexânicos de K.coriacea e K. lathrophyton, 13 sendo descrito que os acil floroglucinóis poliprenilados isolados destas plantas possuem atividade anticancerígena in vivo e in vitro. 14 O estudo químico e biológico de óleos essenciais obtidos de diversas espécies vegetais tem recebido destaque, principalmente quando envolvem atividade antitumoral.…”

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Essential Oils from Fruits and Leaves of Kielmeyera coriacea: Antitumor Activity and Chemical Study

Cazal

Lemes²,

Costa³

et al. 2017

Rev. Virtual Quim.

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Kielmeyera coriacea, a typical tree species of the Cerrado (Brazilian Savanna), popularly known as "pausanto" and it is used in traditional medicine for the treatment of various diseases. This study aimed to chemically characterize the essential oils of leaves and fruits of K. coriacea and to evaluate its antitumor activity against human tumor cell lines MDA-MB-231 (breast tumor) and DU-145 (prostate tumor) as a way to search for new drugs derived from natural sources. Essential oils were extracted by hydrodistillation in Clevenger. The average yield of essential oil of leaves and fruits was 0.38% and 0.0041%, respectively. In leaves from K. coriacea, the major compounds found in the essential oils, were geranyl linalool (27,78), 2-Acetate (2E) Tridecenol (9.06%), E-nerolidol (7.70%) and α-bisabolol (5,09). The major compounds found in essential oils of fruits were D-germacrene (18.94%), neointermedeol (12.18%), bicyclogermacrene (12.00%), Viridiflorol (9,30 %), Globulol (8,76%), Epi-α-muurolol (8,13%) a d δ-cadinene (5,00%).. The essential oils of fruits inhibited the proliferation of tumor cell lines DU-145 and MDA-MB-231, as well as of the non-tumor cells (FH-Human fibroblasts). By contrast the essential oils of leaves were not active in any tested tumor lineage. To our knowledge, this is the first report on the chemical composition and antitumor activity of this species, and it clearly enhance our chemical knowledge of this plant.

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