Early determinants of attention and hyperactivity problems in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

Anselmi, Luciana; Menezes, Ana; Barros, Fernando C.; Araújo, Claudia Affonso Silva; Domingues, Marlos Rodrigues; Rohde, Luís Augusto

doi:10.1590/s0102-311x2010001000012

Cited by 29 publications

(27 citation statements)

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“…The prevalence of ADHD and respective 95% CI was calculated for the entire cohort and separately by sex (based on the current literature that consistently reports higher prevalence rates among boys) 5–13. The association between maternal caffeine consumption grouped in three categories <100, 100–299 and ≥300 mg/day and ADHD was evaluated by means of the χ 2 test.…”

Section: Methodsmentioning

confidence: 99%

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Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study

et al. 2016

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ObjectiveStudies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent. The objective of the present study was to evaluate the association between maternal consumption of caffeine during pregnancy and attention deficit hyperactivity disorder (ADHD) at the age of 11 years.MethodologyAll children born in the city of Pelotas, Brazil, during the year 2004, were selected for a cohort study. The mothers were interviewed at birth to obtain information on coffee and yerba mate consumption during pregnancy, among other matters. At the age of 11 years, presence of ADHD was evaluated using the Development and Well-Being Assessment (DAWBA) questionnaire, applied to the mothers. The prevalence of ADHD was calculated, with 95% CIs. The association between caffeine consumption and ADHD was tested by means of logistic regression.Results3485 children were included in the analyses. The prevalence of ADHD was 4.1% (95% CI 3.4% to 4.7%): 5.8% (95% CI 4.7% to 6.9%) among boys and 2.3% (95% CI 1.5% to 3.0%) among girls. The prevalence of caffeine consumption during the entire pregnancy and in the first, second and third trimesters was 88.7% (87.7% to 89.7%), 86.5% (85.4% to 87.5%), 83.0% (81.8% to 84.2%) and 92.3% (91.4% to 93.1%), respectively. Caffeine consumption during the entire pregnancy and the first, second and third trimesters were not associated with ADHD in the crude or adjusted analysis.ConclusionsThe present study did not show any association between maternal caffeine consumption during pregnancy and ADHD at the age of 11 years.

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Section: Methodsmentioning

confidence: 99%

“…Epidemiological studies have shown higher prevalence among boys and among children belonging to families with worse socioeconomic conditions 5–13. Maternal caffeine consumption14 as well as other nutritional factors during pregnancy, such as intake of folic acid,15 iron16 and omega-317 have been investigated as determinants of ADHD.…”

Section: Introductionmentioning

confidence: 99%

Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study

et al. 2016

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“…In studies in Brazil, the estimates of ADHD prevalence in children and adolescents range from 5.8% to 19.9%, and vary depending on the diagnostic criteria used and the type of sample analyzed [8][9][10][11] . ADHD often persists beyond adolescence into adulthood, although the presentation of symptoms differs between adults, children, and adolescents 12 .…”

Section: Introductionmentioning

confidence: 99%

Lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder: pharmacokinetics, efficacy and safety in children and adolescents

Mattos

2014

Rev. psiquiatr. clín.

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Background: Psychostimulants (methylphenidate and amphetamines) are considered first-line therapy for attention-deficit/hyperactivity disorder (ADHD). Lisdexamfetamine dimesylate (LDX) is a new psychostimulant approved for the treatment of ADHD in Brazil. The pharmacologically active fraction, d-amphetamine, is gradually released by hydrolysis of the LDX prodrug. Objectives: To perform a systematic review of the literature of the efficacy and safety of LDX in the treatment of ADHD in children and adolescents. Methods: Medline/PubMed searches for "d-amfetamine", "lisdexamfetamine" and "lisdexamfetamine dimesylate" were conducted including articles available from January 2000 to November 2013. Additional references were identified using references listed in those articles. Further data on LDX were requested from its manufacturer. Results: Thirty-one papers were found related to ADHD treatment in children and adolescents. Discussion: The therapeutic benefits of LDX in children with ADHD are achieved as early as 1.5 hours after its administration and last for up to 13 hours, with efficacy comparable or superior to that of other available psychostimulants. The literature also reports efficacy in long-term treatment, with safety and tolerability profiles comparable to those of other stimulants used for the treatment of ADHD. Most of the adverse events associated with LDX are considered to be mild or moderate in severity, with the most common being loss of appetite and insomnia.

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“…Muitos autores concordam que a prevalência de transtornos específicos, bem como possíveis fatores de risco e de proteção variam entre as culturas e entre os diversos contextos socioeconômicos (Lund et al, 2010;Lund et al, 2011;Canino & Alegría, 2008;Hackett & Hackett, 1999, Roberts et al, 1998 problemas comportamentais e de saúde mental e idade paterna ; renda familiar (Anselmi et al, 2010), baixo nível socioeconômico (Prior et al, 2005) e tipo de escola (Syed et al, 2007). Lund et al (2010) e Lund et al (2011 verificaram com base em estudo de revisão que, dos 115 estudos analisados, 79% deles relataram associação positiva entre transtornos mentais comuns e alguma medida de pobreza, apontando que as condições sociais e econômicas estão associadas ao aumento destes transtornos em países de baixa e média renda.…”

Section: Associação Entre Aspectos Cognitivos Comportamentais E Emocunclassified

“…Nestes estudos específicos, as taxas de prevalência de problemas mentais foram menores, enquanto que nos estudos de coorte brasileiros mencionados (Gallo et al, 2011;Silva et al, 2011;Anselmi et al 2010), incluindo o presente estudo, as taxas de prevalências foram maiores. Vale ainda o apontamento que em estudos de coorte um grupo de indivíduos compartilha as mesmas experiências culturais e históricos e é avaliado dentro de uma faixa estreita de tempo.…”

Section: Associação Entre Aspectos Cognitivos Comportamentais E Emocunclassified

Riscos biológicos e aspectos cognitivos, comportamentais e emocionais de uma coorte de escolares

Saur¹

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Under the theoretical viewpoint of developmental psychopathology, the existence of biological risks in the development of children, such as low birth weight and prematurity, may maximize conditions of vulnerability and, in long term, bias their adaptation. In reviewing the literature it is noticed the wide range of results concerning cognitive, behavioral, and emotional outcomes associated with these hindrances. In this context, it was proposed a prospective cohort study, with three general objectives: 1) verify the possible association between cognitive, behavioral, and emotional outcomes of a cohort of school-age children, assessed at 10-11 years of age, stratified by three criteria: 1) birth weight (very low birth weight -VLBW, low birth weight -LBW, insufficient birth weight -IBW, normal birth weight -NBW, and high birth weight -HBW; gestational age (preterm and at term); and size at birth (small for gestational age -SGA and appropriate for gestational age -AGA); 2) identify the predictors for the cognitive, behavioral, and emotional outcomes, based on biological, clinical and socioeconomic variables; and 3) establish the rates of behavioral problems in the studied cohort, regardless of the criterion that was adopted. For this purpose, we evaluated 677 children, 10-11 years old, of both sexes, from a cohort of Ribeirão Preto, State of São Paulo, Brazil. For the cognitive evaluation were utilized the Raven tests and the Human Figure Drawing (HFD); for behavioral and emotional assessment, parents answered the Strengths and Difficulties Questionnaire (SDQ), and a supplementary questionnaire. Data were analyzed under descriptive, comparative, and predictive approaches, by using nonparametric statistics (p ≤ 0.05). Results indicated that birth weight was not associated with cognitive and behavioral outcomes, except for the hyperactivity scale, in which the VLBW had more indicators of difficulties in comparison to other weight groups. Concerning the emotional outcome the LBW group showed more emotional problems than VLBW and NBW groups. Gestational age was not associated with any of the investigated outcomes and size at birth was associated with the three outcomes examined, with children born SGA displaying more cognitive, behavioral, and emotional problems when compared to children born AGA. In the analysis of prediction, it was found that: maternal education and socioeconomic status were predictive for the three outcomes, the SGA status favored an increase in emotional problems, and boys had greater risks of behavioral problems. The rates of identification of behavioral problems were high, 38.2% for general problems and 53.9% for emotional symptoms. It is concluded that the criterion of size at birth was more accurate for detecting differences in the analyzed outcomes of school-age children. Among the contributions of this study, it is highlighted the identification of predictive variables and comparisons including factors of biological and socioeconomic risk across a single cohort, stratified by three criteria,...

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Early determinants of attention and hyperactivity problems in adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

Abstract: The aim of this study was to assess early determinants of attention and hyperactivity problems in adolescents. In 1993, all hospital

Cited by 29 publications

References 28 publications

Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study

Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study

Lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder: pharmacokinetics, efficacy and safety in children and adolescents

Riscos biológicos e aspectos cognitivos, comportamentais e emocionais de uma coorte de escolares

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