Evolução da contagem de células T CD4+ de portadores de AIDS em contextos socialmente desiguais

Patroclo, Maria Aparecida de Assis; Medronho, Roberto de Andrade

doi:10.1590/s0102-311x2007000800022

Cited by 6 publications

(7 citation statements)

References 17 publications

(13 reference statements)

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“…The most indicated mediating mechanisms amongst the socioeconomic variables and therapeutic response, are lower rates of treatment adherence [4]–[6] and difficulty in accessing healthcare [6]. There is no consensus in the literature on the relationship between factors such as smoking, alcohol and illicit drug use and their effect on the CD4 count over time.…”

Section: Introductionmentioning

confidence: 99%

“…There is no consensus in the literature on the relationship between factors such as smoking, alcohol and illicit drug use and their effect on the CD4 count over time. Some authors suggest that these factors may be related to adherence to antiretroviral treatment [4], [7], or as a direct agent in immunosuppression, as in the case of alcohol and illicit drug abuse [8].…”

Section: Introductionmentioning

confidence: 99%

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Factors Related to Changes in CD4+ T-Cell Counts over Time in Patients Living with HIV/AIDS: A Multilevel Analysis

et al. 2014

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BackgroundThe measurement of CD4+ T-cell (CD4) counts is a strong predictor of progression to AIDS and a means of monitoring antiviral therapy (ART). The success or failure of controlling virus levels in untreated patients or those taking ART may be associated with treatment adherence, habits, correlated infections unrelated to HIV, cancer, immunosuppressive drugs; as well as socio-economic and psychosocial aspects and access to healthcare. The aim of the present study was to identify, using a multilevel model, the factors related to the variations of CD4 counts over time, in patients living with HIV.MethodologyA cohort study was conducted with patients living with HIV, selected from July 2007 to December 2010. Patients were monitored from records of their first CD4 count after being diagnosed with HIV. A multilevel model with 3 levels of aggregation was applied to analyze the associations of predictor variables and the behavior of CD4 over time.Principal FindingsA total of 1870 patients were enrolled. The mean number of CD4 at the beginning of the cohort was 393.1 cells/mm3, and there was a mean increase of 1.529 cells/mm3 per month. Patient's age, smoking, use of illicit drugs, hospital treatment, changing doctors and the use of ART, were factors that affected the kinetics of the CD4 count during the follow-up period.Conclusion/SignificanceThe results of this study indicated increased levels of CD4 over time in a cohort of patients living with HIV/AIDS and identified factors that may influence this increase and are liable to intervention.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors Related to Changes in CD4+ T-Cell Counts over Time in Patients Living with HIV/AIDS: A Multilevel Analysis

et al. 2014

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“…Diversos fatores podem influenciar no estado nutricional de indivíduos com HIV, incluindo o aparecimento de infecções secundárias e o uso da própria terapia medicamentosa. Estudos apontam que o advento da terapia antiretroviral de alta potência (highly active antiretroviral therapy -HAART), tem promovido aumento dos casos de eutrofia e sobrepeso em indivíduos com HIV, o que pode se justificar pela capacidade que alguns antirretrovirais, como os inibidores de protease, têm de alterar o perfil lipídico e contribuir para o aparecimento de liposdistrofia, além do fato de a HAART colaborar para o aumento de expectativa de vida desse público (31,32) . No entanto, o atual trabalho não analisou a influência do estudo da HAART sobre o estado nutricional.…”

Section: Discussionunclassified

Associação entre diferentes métodos de avaliação nutricional em pacientes com HIV/AIDS em um hospital público

Costa

Neto²,

Campêlo

et al. 2017

RBPS

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“…Approximately 40.0% of HIV-positive individuals were admitted to reference health care units located in favela communities in Rio de Janeiro, RJ, Southeastern Brazil, in late stages. 14 At an outpatient clinic in central Sao Paulo, 52.0% of seropositive individuals were found to have at least one opportunistic AIDS-defining disease prior to admission. 2 Late diagnosis of HIV/AIDS infection does not seem to be exclusive to Brazilian services: the median CD4+ T lymphocyte count upon admission to reference health care units in a multicenter study in the United States was between 167 and 175 cells/mm 3 .…”

Section: Discussionmentioning

confidence: 99%

HIV testing and clinical status upon admission to a specialized health care unit in Pará, Brazil

Abati

Segurado

2015

Rev. Saúde Pública

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OBJECTIVE To analyze the clinical and laboratory characteristics of HIV-infected individuals upon admission to a reference health care center.METHODS This cross-sectional study was conducted between 1999 and 2010 on 527 individuals with confirmed serological diagnosis of HIV infection who were enrolled in an outpatient health care service in Santarém, PA, Northern Brazil. Data were collected from medical records and included the reason for HIV testing, clinical status, and count of peripheral CD4+ T lymphocytes upon enrollment. The data were divided into three groups, according to the patient’s year of admission – P1 (1999-2002), P2 (2003-2006), and P3 (2007-2010) – for comparative analysis of the variables of interest.RESULTS In the study group, 62.0% of the patients were assigned to the P3 group. The reason for undergoing HIV testing differed between genders. In the male population, most tests were conducted because of the presence of symptoms suggesting infection. Among women, tests were the result of knowledge of the partner’s seropositive status in groups P1 and P2. Higher proportion of women undergoing testing because of symptoms of HIV/AIDS infection abolished the difference between genders in the most recent period. A higher percentage of patients enrolling at a more advanced stage of the disease was observed in P3.CONCLUSIONS Despite the increased awareness of the number of HIV/AIDS cases, these patients have identified their serological status late and were admitted to health care units with active disease. The HIV/AIDS epidemic in Pará presents specificities in its progression that indicate the complex characteristics of the epidemic in the Northern region of Brazil and across the country.

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Evolução da contagem de células T CD4+ de portadores de AIDS em contextos socialmente desiguais

Abstract: This study analyzed the evolution in CD4+ Tcell count in AIDS patients in the city of Rio de

Cited by 6 publications

References 17 publications

Factors Related to Changes in CD4+ T-Cell Counts over Time in Patients Living with HIV/AIDS: A Multilevel Analysis

Factors Related to Changes in CD4+ T-Cell Counts over Time in Patients Living with HIV/AIDS: A Multilevel Analysis

Associação entre diferentes métodos de avaliação nutricional em pacientes com HIV/AIDS em um hospital público

HIV testing and clinical status upon admission to a specialized health care unit in Pará, Brazil

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